L4277

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Showing 1-30 of 150 results for "L4277" within Papers

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.

Christopher M Jenkins et al.

The Journal of biological chemistry, 279(47), 48968-48975 (2004-09-15)

Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis in adipocytes. Despite intense interest in these TAG lipases, their molecular identities thus far are largely unknown. Sequence data base

The DNA sequence of the human X chromosome.

Mark T Ross et al.

Nature, 434(7031), 325-337 (2005-03-18)

The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal

Characterization of the lipolytic activity of endothelial lipase.

Mary G McCoy et al.

Journal of lipid research, 43(6), 921-929 (2002-05-29)

Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity. Using radiolabeled lipid substrates, we characterized the lipolytic activity of this enzyme in comparison to lipoprotein lipase (LPL) and hepatic lipase

Tissue expression pattern and polymorphism of G0S2 gene in porcine.

Yanzhi Jiang et al.

Gene, 539(1), 173-179 (2014-02-04)

Adipose triglyceride lipase (ATGL), catalyzing the initial step of hydrolysis of triacylglycerol (TAG) in adipocytes, has been known to be inhibited by G0/G1 switch protein 2 (G0S2). In this study, we determined tissue expression pattern and polymorphism of G0S2 gene

Lipidemic responses of male broiler chickens to enzyme-supplemented wheat-soybean meal-based diets with various levels of metabolizable energy.

K Karimi et al.

Pakistan journal of biological sciences : PJBS, 16(21), 1295-1302 (2014-02-12)

Effects of 2 various levels of AME (according to the manual recommendation and 100 kcal kg(-1) less than it), 2 levels of endo-beta-D-mannanase enzyme (0, 1 g kg(-1)) and 2 levels of xylanase enzyme (0 and 1 g kg(-1)) on

[Nutritional factors of inflammation induction or lipid mechanism of intestinal endotoxin transport].

P L Okorokov et al.

Fiziologiia cheloveka, 38(6), 105-112 (2013-02-12)

Food behavior disorderes (high fat diet) and systematic strong drinks use could be the most important causes of excess intake of intestinal endotoxin (ET) in circulation (endotoxin aggression development) and induction of inflammation. In this work we investigated antiendotoxin immunity

Different Reactivity of Raw Starch from Diverse Potato Genotypes.

Vadim Khlestkin et al.

Molecules (Basel, Switzerland), 26(1) (2021-01-21)

Potato starch is one of the most important renewable sources for industrial manufacturing of organic compounds. Currently, it is produced from mixed potato varieties that often are harvested from different fields. Meanwhile, tuber starches of various potato breeds differ in

Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity.

T Giller et al.

The Journal of biological chemistry, 267(23), 16509-16516 (1992-08-15)

We have isolated cDNAs coding for two novel human pancreatic lipase (hPL)-related human proteins, referred to as hPL-related proteins 1 and 2 (hPLRP1 and hPLRP2) and for hPL. The two novel proteins show an amino acid sequence identity to hPL

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.

Robert Zimmermann et al.

Science (New York, N.Y.), 306(5700), 1383-1386 (2004-11-20)

Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to

Human hepatic lipase mutations and polymorphisms.

R A Hegele et al.

Human mutation, 1(4), 320-324 (1992-01-01)

Human hepatic lipase (HL) is a 477 residue glycoprotein that hydrolyzes triglycerides from plasma lipoproteins. Familial HL deficiency is a rare recessive disorder that is characterized by premature atherosclerosis and abnormal circulating lipoproteins. While studying the HL gene from the

Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.

Andrew C Lake et al.

Journal of lipid research, 46(11), 2477-2487 (2005-09-10)

Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity. Using bioinformatics, we identified three additional Adiponutrin family members (GS2, GS2-Like, and PNPLA1). Here, we report on

Endothelial lipase modulates pressure overload-induced heart failure through alternative pathway for fatty acid uptake.

Hideto Nakajima et al.

Hypertension (Dallas, Tex. : 1979), 61(5), 1002-1007 (2013-03-06)

Lipoprotein lipase has been considered as the only enzyme capable of generating lipid-derived fatty acids for cardiac energy. Endothelial lipase is another member of the triglyceride lipase family and hydrolyzes high-density lipoproteins. Although endothelial lipase is expressed in the heart

Isocyanide-based multi-component reactions for carrier-free and carrier-bound covalent immobilization of enzymes.

Mohammadi, et al.

Nature Protocols, 18, 1641-1657 (2023)

Adiponutrin: A new gene regulated by energy balance in human adipose tissue.

Yong-Ming Liu et al.

The Journal of clinical endocrinology and metabolism, 89(6), 2684-2689 (2004-06-08)

Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans. We investigated the mRNA expression in sc adipose tissue of

Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity.

Verónica Miksztowicz et al.

Arteriosclerosis, thrombosis, and vascular biology, 34(3), 669-675 (2014-01-25)

To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride

Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas.

Yasuhiro Seki et al.

Biochemical and biophysical research communications, 443(4), 1141-1147 (2014-01-02)

Lung cancer is one of the most frequent causes of cancer-related death worldwide. However, molecular markers for lung cancer have not been well established. To identify novel genes related to lung cancer development, we surveyed publicly available DNA microarray data

In vitro inhibitory effects of Limonium contortirameum and L. virgatum extracts from sardinia on alpha-amylase, alpha-glucosidase and pancreatic lipase.

Marzia Foddai et al.

Natural product communications, 9(2), 181-184 (2014-04-03)

Pancreatic triacylglycerol lipase (PL), alpha-amylase and alpha-glucosidase are interesting pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Limonium spp (Plumbaginaceae) are endemic to Sardinia, Italy. Comparable with acarbose, aqueous extracts (AE) of L. contortirameum and L. virgatum, and

Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils.

Mark J White et al.

Infection and immunity, 82(4), 1559-1571 (2014-01-24)

Staphylococcus aureus is an important human pathogen that employs a large repertoire of secreted virulence factors to promote disease pathogenesis. Many strains of S. aureus possess a plc gene that encodes a phosphatidylinositol (PI)-specific phospholipase C (PI-PLC) capable of hydrolyzing

The DNA sequence of human chromosome 22.

I Dunham et al.

Nature, 402(6761), 489-495 (1999-12-11)

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and

Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function.

Daniela Tavian et al.

Human molecular genetics, 21(24), 5318-5328 (2012-09-20)

The lack of adipose triglyceride lipase (ATGL), a patatin-like phospholipase domain-containing enzyme that hydrolyzes fatty acids from triacylglycerol (TAG) stored in multiple tissues, causes the autosomal recessive disorder neutral lipid storage disease with myopathy (NLSD-M). In two families of Lebanese

Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.

Matthew K Ross et al.

Journal of biochemical and molecular toxicology, 21(4), 187-196 (2007-10-16)

Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that hydrolyze esterified xenobiotics to alcohol and carboxylic acid products. However, there is a growing appreciation for the role of CEs in the processing of endobiotics, including cholesteryl esters and triacylglycerols.

High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle.

Pierre-Marie Badin et al.

Endocrinology, 154(4), 1444-1453 (2013-03-09)

Elevated expression/activity of adipose triglyceride lipase (ATGL) and/or reduced activity of hormone-sensitive lipase (HSL) in skeletal muscle are causally linked to insulin resistance in vitro. We investigated here the effect of high-fat feeding on skeletal muscle lipolytic proteins, lipotoxicity, and

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas.

M B Mazzucco et al.

The Journal of endocrinology, 217(3), 303-315 (2013-03-14)

Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on

Structure of the human hepatic triglyceride lipase gene.

S J Cai et al.

Biochemistry, 28(23), 8966-8971 (1989-11-14)

The structure of the human hepatic triglyceride lipase gene was determined from multiple cosmid clones. All the exons, exon-intron junctions, and 845 bp of the 5' and 254 bp of the 3' flanking DNA were sequenced. Comparison of the exon

Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.

M R Probst et al.

The Journal of biological chemistry, 269(34), 21650-21656 (1994-08-26)

Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. Activity determination and immunoblot analysis of DAC in human

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis.

Shaoqing He et al.

The Journal of biological chemistry, 285(9), 6706-6715 (2009-12-26)

Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in humans.

Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.

M W Bodmer et al.

Biochimica et biophysica acta, 909(3), 237-244 (1987-08-25)

The molecular cloning of a cDNA coding for human gastric lipase and its expression in yeast is described. A lipase present in human gastric aspirates was purified and its N-terminal amino-acid sequence was determined. This was found to be homologous

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Daniela S Gerhard et al.

Genome research, 14(10B), 2121-2127 (2004-10-19)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random

Human milk bile-salt stimulated lipase. Sequence similarity with rat lysophospholipase and homology with the active site region of cholinesterases.

D L Christie et al.

FEBS letters, 278(2), 190-194 (1991-01-28)

To determine the active site residue, human milk bile-salt stimulated lipase (BSSL) was labelled with [3H]diisopropyl fluorophosphate (DFP). Partial sequence analysis of cyanogen bromide fragments (a total of 146 residues from 6 peptides) revealed 84% sequence identity with a putative

Properties and purification of adipose tissue lipase.

W S LYNN et al.

The Journal of biological chemistry, 235, 1912-1916 (1960-07-01)

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