Learn the tips and tricks of selecting and preparing a suitable mobile phase buffer for your HPLC separations and method developments for samples that contain ionizable compounds.
The article describes the use of difluoroacetic acid (DFA) as an effective alternative to acid modifiers, formic acid (FA) and trifluoroacetic acid (TFA) in the LC-UV/MS analysis of proteins.
This study is aimed at developing and validating an LC-ESI-ion trap-MS/MS method for identification and quantification of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as ethanol biomarkers for urine analysis.
This article presents an LC-MS/MS method for the determination of tramadol in urine samples using reversed-phase LC-MS/MS aided by isotope internal standards.
This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.
BIOshell™ IgG 1000 Å C4 columns are highly suited for the reversed phase separation of high molecular weight compounds such as monoclonal antibodies with molecular weight of 150 kDa.
In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
Although both biphenyl and phenyl-hexyl phases can resolve these compounds, the former exhibits excellent peak shape and substantially less silanol-derived ion exchange activity.
We offer a variety of ethyl acetate products suitable for applications including GC, HPLC, UHPLC, and LC-MS. We also supply multiple options for anhydrous ethyl acetate and ACS grade ethyl acetate.
Enhanced selectivity for stereoisomers and closely related compounds with alternate selectivity from C18 phases for basic, acidic, or neutral compounds