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Showing 1-25 of 25 results for "MBD0041" within Papers
Muriel Derrien et al.
Frontiers in microbiology, 2, 166-166 (2011-09-10)
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading bacteria. To study the effect of mucus degradation on the host response, germ-free mice
David Berry et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4720-4725 (2013-03-15)
The animal and human intestinal mucosa secretes an assortment of compounds to establish a physical barrier between the host tissue and intestinal contents, a separation that is vital for health. Some pathogenic microorganisms as well as members of the commensal
Michael Wagner et al.
Current opinion in microbiology, 6(3), 302-309 (2003-07-02)
Fluorescence in situ hybridisation with rRNA-targeted nucleic acid probes can be used to directly identify microorganisms within complex samples in a few hours and therefore has widespread application in environmental and medical microbiology. The past year has seen significant methodological
David Berry et al.
The ISME journal, 6(11), 2091-2106 (2012-05-11)
Human inflammatory bowel disease and experimental colitis models in mice are associated with shifts in intestinal microbiota composition, but it is unclear at what taxonomic/phylogenetic level such microbiota dynamics can be indicative for health or disease. Here, we report that
Chin Wen Png et al.
The American journal of gastroenterology, 105(11), 2420-2428 (2010-07-22)
Mucosa-associated bacteria are increased in inflammatory bowel disease (IBD), which suggests the possibility of an increased source of digestible endogenous mucus substrate. We hypothesized that mucolytic bacteria are increased in IBD, providing increased substrate to sustain nonmucolytic mucosa-associated bacteria. Mucolytic
Muriel Derrien et al.
Applied and environmental microbiology, 74(5), 1646-1648 (2007-12-18)
A 16S rRNA-targeted probe, MUC-1437, was designed and validated in order to determine the presence and numbers of cells of Akkermansia muciniphila, a mucin degrader, in the human intestinal tract. As determined by fluorescent in situ hybridization, A. muciniphila accounted
Leore T Geller et al.
Science (New York, N.Y.), 357(6356), 1156-1160 (2017-09-16)
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine. Metabolism was dependent on the expression of
Noora Ottman et al.
Best practice & research. Clinical gastroenterology, 31(6), 637-642 (2018-03-24)
The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine
Clara Belzer et al.
The ISME journal, 6(8), 1449-1458 (2012-03-23)
The human intestinal tract is colonized by a myriad of microbes that have developed intimate interactions with the host. In healthy individuals, this complex ecosystem remains stable and resilient to stressors. There is significant attention on the understanding of the
Elsa Prudent et al.
FEMS microbiology reviews, 43(1), 88-107 (2018-11-13)
Many obligate or facultative intracellular bacteria pose a critical problem in clinical microbiology diagnosis as a result of their fastidious growth or lack of growth in conventional culture media. Molecular diagnosis is based on the analysis and demonstration of nucleic
Lv Wang et al.
Applied and environmental microbiology, 77(18), 6718-6721 (2011-07-26)
Gastrointestinal disturbance is frequently reported for individuals with autism. We used quantitative real-time PCR analysis to quantify fecal bacteria that could influence gastrointestinal health in children with and without autism. Lower relative abundances of Bifidobacteria species and the mucolytic bacterium
R I Amann et al.
Applied and environmental microbiology, 56(6), 1919-1925 (1990-06-01)
Fluorescent oligonucleotide hybridization probes were used to label bacterial cells for analysis by flow cytometry. The probes, complementary to short sequence elements within the 16S rRNA common to phylogenetically coherent assemblages of microorganisms, were labeled with tetramethylrhodamine and hybridized to
Husen Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(7), 2365-2370 (2009-01-24)
Recent evidence suggests that the microbial community in the human intestine may play an important role in the pathogenesis of obesity. We examined 184,094 sequences of microbial 16S rRNA genes from PCR amplicons by using the 454 pyrosequencing technology to
Alexander Swidsinski et al.
Gut, 60(1), 34-40 (2009-11-21)
Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies from healthy and disease controls. We investigated sections of 70 appendices using
Cathleen Schlundt et al.
Molecular ecology resources, 20(3), 620-634 (2019-11-30)
Plastic marine debris (PMD) affects spatial scales of life from microbes to whales. However, understanding interactions between plastic and microbes in the "Plastisphere"-the thin layer of life on the surface of PMD-has been technology-limited. Research into microbe-microbe and microbe-substrate interactions
Anna Pärtty et al.
The Journal of pediatrics, 163(5), 1272-1277 (2013-08-07)
To evaluate the impact of early prebiotic and probiotic intervention on preterm infants' well-being, crying, growth, and microbiological programming. Ninety-four preterm infants (gestational age 32-36 weeks and birth weight >1500 g) randomized to receive prebiotics (mixture of galacto-oligosaccharide and polydextrose
Muriel Derrien et al.
International journal of systematic and evolutionary microbiology, 54(Pt 5), 1469-1476 (2004-09-25)
The diversity of mucin-degrading bacteria in the human intestine was investigated by combining culture and 16S rRNA-dependent approaches. A dominant bacterium, strain MucT, was isolated by dilution to extinction of faeces in anaerobic medium containing gastric mucin as the sole
Sven Poppert et al.
Journal of medical microbiology, 59(Pt 1), 65-68 (2009-10-03)
This study evaluated fluorescence in situ hybridization (FISH) for rapid identification of Staphylococcus aureus and coagulase-negative staphylococci (CoNS) directly from blood cultures. Initially, 360 blood cultures containing Gram-positive cocci were investigated by a previously described microwave-FISH procedure: 44/49 (89.8 %)
Bhanu Priya Ganesh et al.
PloS one, 8(9), e74963-e74963 (2013-09-17)
Excessive mucin degradation by intestinal bacteria may contribute to inflammatory bowel diseases because access of luminal antigens to the intestinal immune system is facilitated. This study investigated how the presence of a mucin degrading commensal bacterium affects the severity of
M Carmen Collado et al.
Applied and environmental microbiology, 73(23), 7767-7770 (2007-10-16)
Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of
Ting Zhang et al.
Microbial biotechnology, 12(6), 1109-1125 (2019-04-23)
Akkermansia muciniphila (A. muciniphila), an intestinal symbiont colonizing in the mucosal layer, is considered to be a promising candidate as probiotics. A. muciniphila is known to have an important value in improving the host metabolic functions and immune responses. Moreover, A. muciniphila may
Jiming Jiang
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 27(3), 153-165 (2019-03-11)
Fluorescence in situ hybridization (FISH) was developed more than 30 years ago and has been the most paradigm-changing technique in cytogenetic research. FISH has been used to answer questions related to structure, mutation, and evolution of not only individual chromosomes but
A Santacruz et al.
The British journal of nutrition, 104(1), 83-92 (2010-03-09)
Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant
David Berry et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(2), E194-E203 (2015-01-01)
Microbial communities are essential to the function of virtually all ecosystems and eukaryotes, including humans. However, it is still a major challenge to identify microbial cells active under natural conditions in complex systems. In this study, we developed a new
Raju Sekar et al.
Applied and environmental microbiology, 69(5), 2928-2935 (2003-05-07)
We tested a previously described protocol for fluorescence in situ hybridization of marine bacterioplankton with horseradish peroxidase-labeled rRNA-targeted oligonucleotide probes and catalyzed reporter deposition (CARD-FISH) in plankton samples from different lakes. The fraction of Bacteria detected by CARD-FISH was significantly
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