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Showing 1-30 of 106 results for "N7878" within Papers
B A Cunha
Obstetrical & gynecological survey, 44(5), 399-406 (1989-05-01)
Nitrofurantoin has been in clinical use for more than 35 years for the treatment of urinary tract infections (UTIs). In particular, it has been used to treat acute uncomplicated UTIs, recurrent urinary tract infections, and asymptomatic bacteriuria of pregnancy. Most
Benjamin A Rogers et al.
Microbial drug resistance (Larchmont, N.Y.), 19(2), 100-103 (2013-01-22)
The New Delhi metallo-β-lactamase gene (bla(NDM-1)) has emerged as a worldwide concern among isolates of Enterobacteriaceae. Its epidemiology is been strongly associated with travel and healthcare on the Indian Subcontinent. We report two cases of urinary tract infection with Enterobacteriaceae
[Hepatic injury associated with use of nitrofurantoin].
Y Karmon et al.
Harefuah, 136(5), 406-408 (2000-07-29)
Maria Pränting et al.
Antimicrobial agents and chemotherapy, 52(8), 2734-2741 (2008-06-04)
PR-39 is a porcine antimicrobial peptide that kills bacteria with a mechanism that does not involve cell lysis. Here, we demonstrate that Salmonella enterica serovar Typhimurium can rapidly acquire mutations that reduce susceptibility to PR-39. Resistant mutants appeared at a
Jessina C McGregor et al.
BMC family practice, 14, 25-25 (2013-02-26)
Urinary tract infections (UTIs) are one of the most common infections treated in ambulatory care settings, however the epidemiology differs by age and sex. The incidence of UTI is far greater in females than males, and infection in pediatric patients
Sang Hyun Cho et al.
Antimicrobial agents and chemotherapy, 51(4), 1380-1385 (2007-01-11)
Screening for new antimicrobial agents is routinely conducted only against actively replicating bacteria. However, it is now widely accepted that a physiological state of nonreplicating persistence (NRP) is responsible for antimicrobial tolerance in many bacterial infections. In tuberculosis, the key
C Michiels et al.
Biochimica et biophysica acta, 967(3), 341-347 (1988-12-15)
The toxicity of nitrofurantoin was studied on human WI-38 fibroblasts: this chemical was lethal when added at concentrations higher than 5.10(-5) M in the culture medium. The protection afforded by antioxidants was then tested: alpha-tocopherol gave at 10(-4) M a
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
Daniel Kiblboeck et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-08-29)
Gitte M Knudsen et al.
Applied and environmental microbiology, 79(23), 7390-7397 (2013-09-24)
Listeria monocytogenes can cause the serious infection listeriosis, which despite antibiotic treatment has a high mortality. Understanding the response of L. monocytogenes to antibiotic exposure is therefore important to ensure treatment success. Some bacteria survive antibiotic treatment by formation of
Marieke J M Broes et al.
Nederlands tijdschrift voor geneeskunde, 156(44), A4990-A4990 (2012-11-02)
Acute pulmonary syndrome is an uncommon but severe adverse reaction to nitrofurantoin. This syndrome is seldom recognised at the moment of presentation, which potentially subjects patients to unnecessary treatment and delays in the discontinuation of nitrofurantoin. We discuss the case
Laboratory detection of MRSA.
V Anil Kumar
The new microbiologica, 36(2), 207-207 (2013-06-27)
Rafael Gozalbes et al.
Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemical
D Kumar Reddy et al.
Bioorganic & medicinal chemistry letters, 21(3), 997-1000 (2011-01-08)
A simple, first stereoselective total synthesis of botryolide-E has been described. The synthesis started from propylene oxide employing Jacobsen's hydrolytic kinetic resolution (HKR), selective epoxide opening, sharpless asymmetric dihydroxylation, one pot acetonide deprotection and lactonization as key steps. Further, the
Guy Amit et al.
The Israel Medical Association journal : IMAJ, 4(3), 184-186 (2002-03-23)
Nitrofurantoin is a commonly prescribed urinary antiseptic. Hepatic injury has been associated with its use. To present three patients in whom long-term exposure to the drug resulted in chronic active hepatitis; and to review the epidemiology, clinical immunology, histopathology, pathogenetic
L A Paiva et al.
The American journal of gastroenterology, 87(7), 891-893 (1992-07-01)
Nitrofurantoin-induced hepatic injury has been established unequivocally as an entity by rechallenge experiences. We reviewed 12 previously reported cases in which rechallenge was described. The longest reported interval between initial injury and rechallenge-provoked injury was 4 yr. We report a
Roderich Roemhild et al.
PLoS biology, 18(1), e3000612-e3000612 (2020-01-28)
Antibiotic resistance increasingly limits the success of antibiotic treatments, and physicians require new ways to achieve efficient treatment despite resistance. Resistance mechanisms against a specific antibiotic class frequently confer increased susceptibility to other antibiotic classes, a phenomenon designated collateral sensitivity
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Craig Knox et al.
Nucleic acids research, 39(Database issue), D1035-D1041 (2010-11-10)
DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of both small molecule and large molecule (biotech) drugs.
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Daniel Jackson et al.
Female pelvic medicine & reconstructive surgery, 19(3), 137-141 (2013-04-25)
Because of the reported high percentage of bladder infections after placement of a midurethral sling (8.9%-34%), this study was undertaken to determine if a 3-day postoperative course of a urinary antibiotic would significantly lower the incidence of urinary tract infection
Vidhya Prakash et al.
Antimicrobial agents and chemotherapy, 53(3), 1278-1280 (2009-01-07)
Effective therapeutic options are needed for community-onset urinary tract infections due to Escherichia coli strains that produce CTX-M extended-spectrum beta-lactamases. We examined 46 urinary isolates producing CTX-M against several oral or long-acting parenteral antimicrobial agents. Approximately 90% were susceptible to
Martindale: The Extra Pharmacopoeia
Martindale: The Extra Pharmacopoeia, 1529-1531 (1996)
S C Nickerson et al.
American journal of veterinary research, 46(11), 2259-2265 (1985-11-01)
Effects of antibiotics and antibiotic vehicles on polymorphonuclear leukocytes (PMNL) isolated from bovine mammary glands were studied in vitro. Amikacin, dicloxacillin, erythromycin, gentamicin, lincomycin, nitrofurantoin, novobiocin-penicillin, polymyxin B, rifampin, tetracycline, or tiamulin was added to culture medium at 1 mg/ml
Manthena V S Varma et al.
Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19)
Kidney plays an important role in the elimination of drugs, especially with low or negligible hepatic clearance. An analysis of the interrelation of physicochemical properties and the human renal clearance for a data set of 391 drugs or compounds tested
Hedvig Nordeng et al.
Obstetrics and gynecology, 121(2 Pt 1), 306-313 (2013-01-25)
To estimate whether first-trimester exposure to nitrofurantoin is associated with increased malformation rates and, secondarily, to estimate whether exposure to nitrofurantoin is associated with increased rates of negative pregnancy outcomes and perinatal complications. We conducted a population-based cohort study using
Brian T Veach et al.
Journal of AOAC International, 98(3), 588-594 (2015-05-31)
This paper describes a rapid and robust method utilizing microwave-assisted derivatization, automated SPE, and LC-MS/MS for the quantitation and confirmation of chloramphenicol (CAP) and nitrofuran metabolites in various aquaculture matrixes. The use of equipment presented in this work allowed extractions
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
H Hof
Immunitat und Infektion, 16(6), 220-225 (1988-12-01)
Nitroheterocyclic compounds, such as metronidazole and nitrofurantoin, are widely used in medical practice for the treatment of infectious diseases. Indeed, they exhibit a strong antimicrobial effect, which is directed not only against several groups of bacteria but also against certain
Nalisa Khochamit et al.
Microbiological research, 170, 36-50 (2014-12-03)
The antimicrobial activity and probiotic properties of Bacillus subtilis strain KKU213, isolated from local soil, were investigated. The cell-free supernatant (CFS) of a KKU213 culture containing crude bacteriocins exhibited inhibitory effects on Gram-positive bacteria, including Bacillus cereus, Listeria monocytogenes, Micrococcus
Andrea Endimiani et al.
Antimicrobial agents and chemotherapy, 52(7), 2680-2682 (2008-04-23)
The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative
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