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Showing 1-30 of 403 results for "P5629" within Papers
Wei Zou et al.
European journal of drug metabolism and pharmacokinetics, 40(3), 363-367 (2014-06-18)
Naringin, a major flavonoid in citrus fruits, has been proved to be a promising antitussive candidate. It undertakes complicated metabolism. In this study, human intestinal microbial metabolism of naringin was studied in vitro. Six persons' fecal water, which have intestinal
Dawid Deszcz et al.
The FEBS journal, 282(13), 2512-2526 (2015-04-08)
We have analyzed the natural evolution of transaminase structure and sequence between an α-transaminase serine-pyruvate aminotransferase and an ω-transaminase from Chromobacterium violaceum with < 20% sequence identity, and identified the active-site regions that are least conserved structurally. We also show
Arminja N Kettenbach et al.
Journal of proteomics, 114, 48-60 (2014-12-03)
The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tumors represent significant hurdles for such efforts. In the present work, we design, implement
Tomoki Takeda et al.
Toxicology and applied pharmacology, 278(3), 220-229 (2014-05-06)
We have previously revealed that treating pregnant rats with 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) reduces the expression of gonadotropins and growth hormone (GH) in the fetal and neonatal pituitary. A change in gonadotropin expression impairs the testicular expression of steroidogenic proteins in perinatal
Akshay K Harapanahalli et al.
Applied and environmental microbiology, 81(10), 3369-3378 (2015-03-10)
The majority of human infections are caused by biofilms. The biofilm mode of growth enhances the pathogenicity of Staphylococcus spp. considerably, because once they adhere, staphylococci embed themselves in a protective, self-produced matrix of extracellular polymeric substances (EPSs). The aim
Dennis Wetzl et al.
Chembiochem : a European journal of chemical biology, 16(12), 1749-1756 (2015-06-06)
Recent investigations on imine reductases (IREDs) have enriched the toolbox of potential catalysts for accessing chiral amines, which are important building blocks for the pharmaceutical industry. Herein, we describe the characterization of 20 new IREDs. A C-terminal domain clustering of
Mir-Jamal Hosseini et al.
Cell biochemistry and biophysics, 70(1), 367-381 (2014-04-03)
Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicity. In this study, we aimed
Devavratha H Rao et al.
Phytochemistry, 83, 7-14 (2012-09-11)
Field bean seed contains a Gal/GalNAc lectin (DLL-II) that exhibits associated polyphenol oxidase (PPO) activity and does not bind to its sugar specific affinity matrix. The molecular basis for this lack of binding is not known. The DLL-II gene was
Byung Wook Jo et al.
Carbohydrate polymers, 111, 822-829 (2014-07-20)
A fucoidan extracted from Sargassum fulvellum, was degraded by ultrasound (US) or electron beam (EB) irradiation in the presence of hydrogen peroxide aqueous solution. From the energetic point of view, the most effective method for the fucoidan degradation was found
Jacob P Brady et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), E639-E648 (2015-02-04)
The integral membrane proteins of the DP1 (deleted in polyposis) and reticulon families are responsible for maintaining the high membrane curvature required for both smooth endoplasmic reticulum (ER) tubules and the edges of ER sheets, and mutations in these proteins
Kamaleshwar P Singh et al.
Journal of industrial microbiology & biotechnology, 40(2), 235-244 (2012-11-28)
Secondary metabolites such as antibiotics are typically produced by actinomycetes as a response to growth limiting stress conditions. Several studies have shown that secondary metabolite production is correlated with changes observed in actinomycete pellet morphology. Therefore, we investigated the correlation
Shin Koike et al.
Biochemical and biophysical research communications, 459(3), 488-492 (2015-03-10)
Polysulfides are a typical type of bound sulfur, which is physiologically stable form of sulfur species, derived from the hydrogen sulfide (H2S) that is generated endogenously in cells. We previously reported that bound sulfur protects neuronal cells from oxidative injury.
Xin Xin et al.
Biological & pharmaceutical bulletin, 38(9), 1389-1394 (2015-09-04)
Protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is a Golgi glycosyltransferase that catalyzes the formation of the N-acetylglucosamine (GlcNAc) β1→2Man linkage of O-mannosyl glycan. POMGNT1 is not modified by N-glycans because there are no potential N-glycosylation sites; however, it is not
Dhilushi D Wijayakumara et al.
The Journal of pharmacology and experimental therapeutics, 354(3), 417-425 (2015-07-15)
Given the prime importance of UDP-glucuronosyltransferase (UGT) 2B15 and UGT2B17 in inactivating testosterone and dihydrotestosterone, control of their expression and activity in the prostate is essential for androgen signaling homeostasis in this organ. Although several studies provide evidence of transcriptional
Frank Jansen et al.
Biotechnology and applied biochemistry, 61(6), 646-654 (2014-03-01)
The plant polymer lignin is the greatest source of aromatic chemical structures on earth. Hence, the chemically diverse lignin monomers are valuable raw materials for fine chemicals, materials synthesis, and food and flavor industries. However, extensive use of this natural
Rishikesh Shukla et al.
Probiotics and antimicrobial proteins, 6(1), 11-21 (2014-03-29)
A novel strain of lactic acid bacterium isolated from fermented cucumber was selected due to its high glucansucrase activity. It was identified on the basis of 16S rRNA sequence analysis as Pediococcus pentosaceus CRAG3 (GenBank accession number JX679020). The isolate
Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling.
Bradley W Davis et al.
Biophysical journal, 109(10), 2182-2194 (2015-11-21)
Subcellular compartmentalization of biomolecules and their reactions is common in biology and provides a general strategy for improving and/or controlling kinetics in metabolic pathways that contain multiple sequential enzymes. Enzymes can be colocalized in multiprotein complexes, on scaffolds or inside
Dorottya Kalapis et al.
PLoS biology, 13(11), e1002291-e1002291 (2015-11-07)
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a
Beiyun Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(3), 1142-1150 (2015-06-27)
Diabetes and Alzheimer's disease are often associated with each other, whereas the relationship between two diseases is ill-defined. Although hyperglycemia during diabetes is a major cause of encephalopathy, diabetes may also cause chronic inflammatory complications including peripheral neuropathy. Hence the
Mohd Shkir et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 103, 199-204 (2012-12-25)
Good quality single crystals of potassium dihydrogen orthophosphate (KDP) were grown with different doping concentration of Glycine by conventional solution technique in aqueous solution. X-ray diffraction study has been carried out in order to see the effect of dopant on
Limei Chang et al.
Plant physiology, 169(2), 1127-1140 (2015-08-25)
Transcriptome resources for the medicinal plant Glaucium flavum were searched for orthologs showing identity with characterized O-methyltransferases (OMTs) involved in benzylisoquinoline alkaloid biosynthesis. Seven recombinant proteins were functionally tested using the signature alkaloid substrates for six OMTs: norlaudanosoline 6-OMT, 6-O-methyllaudanosoline
Lennart Leßmeier et al.
Applied microbiology and biotechnology, 99(23), 10163-10176 (2015-08-16)
Methanol, a one-carbon compound, can be utilized by a variety of bacteria and other organisms as carbon and energy source and is regarded as a promising substrate for biotechnological production. In this study, a strain of non-methylotrophic Corynebacterium glutamicum, which
C Di Giorgio et al.
Journal of natural medicines, 69(3), 267-277 (2015-02-11)
DIG, a liquid herbal preparation made from a mixture of diluted mother tinctures of Berberis vulgaris, Taraxacum officinale and Arctium lappa, was assessed for its antimutagenic properties against mitomycin C. The micronucleus assay on Chinese hamster ovary (CHO)-K1 cells was
Ou Zhimin et al.
Applied biochemistry and biotechnology, 168(8), 2297-2308 (2012-10-17)
(S) -3-Chloro-1-(2-thienyl)-1-propanol was synthesized by the asymmetric reduction of 3-chloro-1-(2-thienyl)propanone with liquid-core immobilized Candida pseudotropicalis 104. The optimum time was 28 h for the re-cultivation of immobilized cells. The optimum film solvent for the liquid-core capsule was 0.3 % chitosan (M (w)
Weronika Wituszyńska et al.
Plant, cell & environment, 38(2), 315-330 (2014-01-30)
As obligate photoautotrophs, plants are inevitably exposed to ultraviolet (UV) radiation. Because of stratospheric ozone depletion, UV has become more and more dangerous to the biosphere. Therefore, it is important to understand UV perception and signal transduction in plants. In
Leonor C Costa et al.
Environmental science and pollution research international, 22(23), 18574-18589 (2015-09-24)
This study aimed to assess the mechanisms of innate immune function responses to silica-coated iron oxide nanoparticle functionalized with dithiocarbamate groups (IONP) exposure alone and its associated mercury (Hg) in European eel (Anguilla anguilla L.) phagocytes isolated from peritoneum (P-phagocytes)
Shu-Hui Dai et al.
International journal of molecular sciences, 15(8), 14591-14609 (2014-09-10)
Oxidative stress is a well-established event in the pathology of several neurobiological diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase that regulates mitochondrial function and metabolism in response to caloric restriction and stress. This study aims to investigate
Jörn Karhausen et al.
Critical care medicine, 41(9), e200-e210 (2013-03-13)
Cardiac surgery, especially when employing cardiopulmonary bypass and deep hypothermic circulatory arrest, is associated with systemic inflammatory responses that significantly affect morbidity and mortality. Intestinal perfusion abnormalities have been implicated in such responses, but the mechanisms linking local injury and
Edwin J Squirewell et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 843-850 (2015-03-31)
Tamoxifen is successfully used for both treatment and prevention of estrogen-dependent breast cancer, yet side effects and development of resistance remain problematic. Endoxifen is a major active metabolite of tamoxifen that is being investigated for clinical use. We hypothesized that
Snezana Marković et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 847-855 (2014-12-03)
We describe the development of an in-line monitoring approach for the fluid-bed drying and coating steps for the production of enteric coated pellets by NIR. Our results show that key pellet characteristics can be monitored in-line. Likewise, the finished product
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