PHG0005

Applied Filters:

Keyword:'PHG0005'

Showing 1-9 of 9 results for "PHG0005" within Papers

Metabolic engineering for p-coumaryl alcohol production in Escherichia coli by introducing an artificial phenylpropanoid pathway.

Frank Jansen et al.

Biotechnology and applied biochemistry, 61(6), 646-654 (2014-03-01)

The plant polymer lignin is the greatest source of aromatic chemical structures on earth. Hence, the chemically diverse lignin monomers are valuable raw materials for fine chemicals, materials synthesis, and food and flavor industries. However, extensive use of this natural

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.

Emmanuel H Demont et al.

Journal of medicinal chemistry, 58(14), 5649-5673 (2015-07-15)

Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the

Systematic Comparison and Validation of Quantitative Real-Time PCR Methods for the Quantitation of Adeno-Associated Viral Products.

Natalie Jayne Werling et al.

Human gene therapy methods, 26(3), 82-92 (2015-05-09)

Adeno-associated viral (AAV) vectors show great promise for gene therapy because of their excellent safety profile; however, development of robust dose-determining assays for AAV has presented a significant challenge. With the ultimate goal of future harmonization and standardization of AAV

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

Milya Davlieva et al.

Nucleic acids research, 43(9), 4758-4773 (2015-04-22)

LiaR is a 'master regulator' of the cell envelope stress response in enterococci and many other Gram-positive organisms. Mutations to liaR can lead to antibiotic resistance to a variety of antibiotics including the cyclic lipopeptide daptomycin. LiaR is phosphorylated in

Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases.

Roland D Kersten et al.

ACS chemical biology, 10(11), 2501-2511 (2015-09-18)

Terpenes are ubiquitous natural chemicals with diverse biological functions spanning all three domains of life. In specialized metabolism, the active sites of terpene synthases (TPSs) evolve in shape and reactivity to direct the biosynthesis of a myriad of chemotypes for

Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis.

Francesca Spyrakis et al.

ChemMedChem, 9(7), 1501-1511 (2014-03-13)

Cystalysin from Treponema denticola is a pyridoxal 5'-phosphate dependent lyase that catalyzes the formation of pyruvate, ammonia, and sulfide from cysteine. It is a virulence factor in adult periodontitis because its reaction contributes to hemolysis, which sustains the pathogen. Therefore

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.

Stephanie A Shumar et al.

PloS one, 10(6), e0130013-e0130013 (2015-06-09)

Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms. PanK initiates the synthesis of coenzyme A

Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2).

Justin P Ludeman et al.

Organic & biomolecular chemistry, 13(7), 2162-2169 (2014-12-24)

Tyrosine sulfation is a widespread post-translational modification that mediates the interactions of secreted and membrane-associated proteins in such varied biological processes as peptide hormone action, adhesion, blood coagulation, complement activation and regulation of leukocyte trafficking. Due to the heterogeneous nature

Protonated rhodosemiquinone at the Q(B) binding site of the M265IT mutant reaction center of photosynthetic bacterium Rhodobacter sphaeroides.

Ágnes Maróti et al.

Biochemistry, 54(12), 2095-2103 (2015-03-12)

The second electron transfer from primary ubiquinone Q(A) to secondary ubiquinone Q(B) in the reaction center (RC) from Rhodobacter sphaeroides involves a protonated Q(B)(-) intermediate state whose low pK(a) makes direct observation impossible. Here, we replaced the native ubiquinone with

Page 1 of 1