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Showing 61-90 of 436 results for "phr1047" within Papers
Linlin Qi et al.
Analytical and bioanalytical chemistry, 407(13), 3617-3625 (2015-03-23)
An aqueous two-phase microfluidics (ATPM) method suitable for selective extraction of bisphenol A (BPA) in aqueous samples was developed, and a functional ionic liquid of N, N, N-trioctyl ammonium propionate (TOAP) was specially employed for the formation of a parallel
Erik van Kampen et al.
PloS one, 9(10), e109024-e109024 (2014-10-28)
Oxysterol binding protein Related Proteins (ORPs) mediate intracellular lipid transport and homeostatic regulation. ORP8 downregulates ABCA1 expression in macrophages and cellular cholesterol efflux to apolipoprotein A-I. In line, ORP8 knockout mice display increased amounts of HDL cholesterol in blood. However
Steven Pham et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 436-444 (2014-09-10)
Castration resistant prostate cancer (CRPC) is often lethal and inevitably develops after androgen ablation therapy. However, in the majority of cases it remains androgen dependent. CRPC tumors have the ability to synthesize their own androgens from cholesterol by engaging in
Laetitia Asser et al.
Molecular and cellular endocrinology, 395(1-2), 1-9 (2014-07-25)
Glucocorticoid receptor (GR), a ubiquitous transcriptional factor, regulates target gene expression upon activation by glucocorticoids, notably cortisol, a corticosteroid hormone synthesized in the adrenal cortex. We thus hypothesized that both GR and cortisol might be involved in the regulation of
Vitor Cabral et al.
PLoS pathogens, 10(12), e1004542-e1004542 (2014-12-17)
Biofilm formation is an important virulence trait of the pathogenic yeast Candida albicans. We have combined gene overexpression, strain barcoding and microarray profiling to screen a library of 531 C. albicans conditional overexpression strains (∼10% of the genome) for genes
Matt Hrapchak et al.
Journal of labelled compounds & radiopharmaceuticals, 57(12), 687-694 (2014-10-22)
Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of carbon-13 and carbon-14 labeled empagliflozin. Carbon-13 labeled empagliflozin was prepared in five steps and in 34% overall
Milica Vujicic et al.
The British journal of nutrition, 113(5), 770-782 (2015-02-12)
Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin replacement, the aim of the present study was to evaluate the therapeutic potential
Md Mahmudur Rahman et al.
Journal of chromatography. A, 1314, 241-248 (2013-09-28)
An experimental technique based on sorbent tube-thermal desorption-gas chromatography (ST-TD-GC) was investigated for the simultaneous determination of a cluster of eight volatile odorants (propionic acid, n-butyric acid, i-valeric acid, n-valeric acid, trimethylamine, phenol, indole, and skatole) and a reference compound
Zhi-Ling Guo et al.
Brain research, 1229, 125-136 (2008-07-29)
The midline medulla oblongata, which includes the nucleus raphe obscurus, raphe magnus and raphe pallidus (NRP), is involved in regulation of cardiovascular responses. Opioids and serotonin (5-HT) are thought to function as important neurotransmitters in this region. We previously have
Soo Jung Lee et al.
International journal of biological macromolecules, 72, 1056-1062 (2014-12-03)
Lignin was isolated from the residue of bioethanol production with oak wood via alkaline and catalyzed organosolv treatments at ambient temperature to improve the purity of lignin for the materials application. The isolated lignins were analyzed for their chemical composition
Guillermo Marcial et al.
Journal of ethnopharmacology, 155(2), 1125-1133 (2014-07-06)
The aerial parts of Lippia integrifolia (Gris.) Hieronymus (Verbenaceae), known as incayuyo, are used by the peasant population of Argentina for treatment of diseases related to a gastrointestinal system, mainly for inflammation of the stomach and have also been included
Yu-Jen Shih et al.
Environmental science and pollution research international, 20(9), 6184-6190 (2013-04-17)
The degradation of phenol in acidic solution at pH 3 has been investigated under various photo- and electrochemical conditions. A laboratory-scale reactor on which were mounted net electrodes (RuO2/IrO2-coated Ti anodes (DSA) and stainless steel cathodes) and 254 nm UV lamps was
Zhenyu Cheng et al.
Journal of pharmaceutical and biomedical analysis, 96, 162-169 (2014-04-24)
A method for two-steps extraction of essential oil, polysaccharides and lignans from Schisandra chinensis Baill had been established. Firstly, S. chinensis was extracted by hydro-distillation, the extracted solution was separated from the water-insoluble residue and precipitated by adding dehydrated alcohol
Abigail K Myers et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(23), 7787-7801 (2014-06-06)
Proper assembly of cortical circuitry relies on the correct migration of cortical interneurons from their place of birth in the ganglionic eminences to their place of terminal differentiation in the cerebral cortex. Although molecular mechanisms mediating cortical interneuron migration have
Rectovaginal fistula: an extremely rare complication after injection sclerotherapy for hemorrhoids.
Sukanta Ray et al.
The American surgeon, 79(4), E143-E144 (2013-04-12)
Sreejith Kottuparambil et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 9-14 (2014-06-24)
Phenol, a monosubstituted aromatic hydrocarbon with various commercial uses, is a major organic constituent in industrial wastewaters. The ecotoxic action of phenol for aquatic environment is well known. In this study, rapid phenol toxicity tests (1h) were developed based on
Yukie Yoda et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 18(1), 65-76 (2014-02-11)
The profiles of genetic and epigenetic alterations in cancer-related pathways are considered to be useful for selection of patients likely to respond to specific drugs, including molecular-targeted and epigenetic drugs. In this study, we aimed to characterize such profiles in
Pankaj Aggarwal et al.
Journal of chromatography. A, 1364, 96-106 (2014-09-07)
Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of small molecules. Tergitol was used as a surfactant
Ammar A Albalasmeh et al.
Carbohydrate polymers, 97(2), 253-261 (2013-08-06)
A new UV spectrophotometry based method for determining the concentration and carbon content of carbohydrate solution was developed. This method depends on the inherent UV absorption potential of hydrolysis byproducts of carbohydrates formed by reaction with concentrated sulfuric acid (furfural
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.
Ageliki Tsagaratou et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(32), E3306-E3315 (2014-07-30)
The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell
Cécilia Abarrategui-Pontes et al.
Current gene therapy, 14(5), 365-376 (2015-02-18)
Zinc finger nucleases (ZFNs) are promising tools for genome editing for biotechnological as well as therapeutic purposes. Delivery remains a major issue impeding targeted genome modification. Lentiviral vectors are highly efficient for delivering transgenes into cell lines, primary cells and
Annika Kasten et al.
PloS one, 9(9), e108055-e108055 (2014-09-23)
Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies for tissue engineering.
Hichem Alimi et al.
General physiology and biophysics, 32(1), 115-127 (2013-03-28)
Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro
Determination of trace amounts of phenol in river waters by gas chromatography
Rennie.JP
Analyst, 107, 327-330 (1982)
Christoph Roderburg et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1172-1184 (2014-07-22)
Serum concentrations of miR-122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in miR-122 serum levels are unknown. We analysed miR-122 serum levels and hepatic miR-122 expression in mice after hepatic ischaemia and reperfusion
Jung-Ting Lee et al.
Endocrinology, 155(9), 3409-3420 (2014-06-11)
Macrophage metalloelastase, a matrix metallopeptidase (MMP12) predominantly expressed by mature tissue macrophages, is implicated in pathological processes. However, physiological functions for MMP12 have not been described. Because mRNA levels for the enzyme increase markedly in adipose tissue of obese mice
Neha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(8), 777-787 (2014-05-29)
A huge body evidences suggest that obesity is the single great risk factor for the development of dementia. Recently, silymarin, a flavonoid, clinically in use as a hepatoprotectant, has been reported to prevent amyloid beta-induced memory impairment by reducing oxidative
Zheng Wang et al.
Applied and environmental microbiology, 81(2), 699-712 (2014-11-16)
Biocathode extracellular electron transfer (EET) may be exploited for biotechnology applications, including microbially mediated O2 reduction in microbial fuel cells and microbial electrosynthesis. However, biocathode mechanistic studies needed to improve or engineer functionality have been limited to a few select
Piyasuda Thepnok et al.
Biochemical and biophysical research communications, 450(4), 1276-1282 (2014-07-08)
Many zinc cluster proteins have been shown to play a role in the transcriptional regulation of glucose-repressible genes during glucose exhaustion and diauxic shift. Here, we studied an additional member of this family called Yer184c (herein called Tog1) for transcriptional
Rahul Yadav et al.
The Journal of clinical endocrinology and metabolism, 99(9), 3390-3398 (2014-05-16)
Obstructive sleep apnea (OSA) complicates morbid obesity and is associated with increased cardiovascular disease incidence. An increase in the circulating markers of chronic inflammation and dysfunctional high-density lipoprotein (HDL) occur in severe obesity. The objective of the study was to
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