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Showing 1-30 of 168 results for "PHR1067" within Papers
Ajay K Srivastava et al.
Epilepsia, 54(7), 1186-1194 (2013-06-12)
Kindling is a well-established model of secondarily generalized partial seizures that is widely employed in the search for novel antiseizure drugs. During the kindling and postkindling acquisition phase, an active process of neuronal remodeling occurs. We tested the hypothesis that
Nurcan Bektas et al.
Life sciences, 95(1), 9-13 (2013-12-24)
The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain
Sidy Ba et al.
Journal of hazardous materials, 280, 662-670 (2014-09-15)
Widespread detection of numerous micropollutants including aromatic pharmaceuticals in effluents of wastewater treatment plants has prompted much research aimed at efficiently eliminating these contaminants of environmental concerns. In the present work, a novel hybrid bioreactor (HBR) of cross-linked enzymes aggregates
Zhe Wang et al.
Biomedical chromatography : BMC, 29(2), 188-193 (2014-06-14)
A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine voriconazole in human plasma. Sample preparation was accomplished through a simple one-step protein precipitation with methanol. Chromatographic separation was carried out on an
Teaching video neuroimages: perioral myoclonia with absences in a 12-year-old boy.
Suvasini Sharma et al.
Neurology, 81(15), e116-e116 (2013-10-09)
R Barrons et al.
Journal of clinical pharmacy and therapeutics, 35(2), 153-167 (2010-05-12)
The goal of this review is to evaluate the efficacy and safety of carbamazepine and oxcarbazepine in treatment of alcohol withdrawal syndrome (AWS) and determine the role in therapy of both agents. Relevant literature was identified through a search of
Jae-Sung Kim et al.
Toxicology and applied pharmacology, 273(3), 600-610 (2013-10-16)
Onset of the mitochondrial permeability transition (MPT) plays a causative role in ischemia/reperfusion (I/R) injury. Current therapeutic strategies for reducing reperfusion injury remain disappointing. Autophagy is a lysosome-mediated, catabolic process that timely eliminates abnormal or damaged cellular constituents and organelles
Tae Hwan Kim et al.
Epilepsia, 56(1), e6-e9 (2014-12-10)
Oxcarbazepine (OXC), widely used to treat focal epilepsy, is reported to exacerbate seizures in patients with generalized epilepsy. OXC is metabolized to monohydroxy derivatives in two enantiomeric forms: (R)-licarbazepine and (S)-licarbazepine. Eslicarbazepine acetate is a recently approved antiepileptic drug that
PRRT2 mutation correlated with phenotype of paroxysmal kinesigenic dyskinesia and drug response.
Hong-Fu Li et al.
Neurology, 80(16), 1534-1535 (2013-03-29)
Luca Rossi et al.
PloS one, 8(3), e58864-e58864 (2013-03-14)
The aim of this work was to evaluate low-cost and easy-to-operate engineering solutions that can be added as a polishing step to small wastewater treatment plants to reduce the micropollutant load to water bodies. The proposed design combines a sand
Mohammad Behbahani et al.
Journal of chromatography. A, 1308, 25-31 (2013-08-21)
A simple, rapid, and efficient method, based on surfactant assisted dispersive liquid-liquid microextraction (SA-DLLME), followed by high performance liquid chromatography (HPLC) has been developed for simultaneous preconcentration and trace detection of zonisamide and carbamazepine in biological samples. A conventional cationic
Zhengwei Zhou et al.
Journal of pharmaceutical and biomedical analysis, 106, 37-45 (2014-07-27)
The performance of ferrate(VI) in treating sulfamethoxazole (SMX), diclofenac (DCF), carbamazepine (CBZ) and bezafibrate (BZF) in test solutions containing the four compounds was investigated. A series of jar-test experiments was performed on a bench-scale at pH 6-9 and at a
Dong Wook Kim et al.
International journal of clinical pharmacology and therapeutics, 51(10), 780-786 (2013-07-16)
Oral loading of oxcarbazepine tablet is effective and well tolerated to adequately achieve the therapeutic levels of its active metabolite, 10,11-dihydro-10-hydroxy-carbazepine (monohydroxy derivative, MHD) in epilepsy patients. The present study was performed to investigate the safety, tolerability, and pharmacokinetic profiles
Xiangjun Qiu et al.
Journal of chromatographic science, 53(1), 85-89 (2014-04-29)
In this study, a simple, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method is described for the determination of glipizide in human plasma samples using carbamazepine as the internal standard (IS) from bioequivalence assays. Sample preparation was accomplished
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?
Subramanian Ganesan et al.
Archives of disease in childhood, 96(1), 104-106 (2010-12-21)
HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity.
S Grover et al.
Clinical pharmacology and therapeutics, 93(5), 386-387 (2013-02-28)
Chen-Hsu Wang et al.
Pharmaceutical biology, 52(11), 1451-1459 (2014-07-16)
Abstract Background: Carbamazepine, which was developed primarily for the treatment of epilepsy, is now also useful for the treatment of non-epileptic disorders and inflammatory hyperalgesia. However, the mechanism of its anti-neuroinflammatory action remains poorly understood. This study elucidates the anti-neuroinflammatory
V L Yip et al.
Clinical pharmacology and therapeutics, 92(6), 757-765 (2012-11-08)
Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype. This systematic review determines the strength of these associations and
Fouad F Al-Qaim et al.
Journal of chromatography. A, 1345, 139-153 (2014-04-29)
An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure
Clara Boix et al.
Talanta, 131, 719-727 (2014-10-05)
This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. The water samples were analyzed by ultra-high-performance liquid chromatography coupled to
Ganna Fedorova et al.
Chemosphere, 111, 55-60 (2014-07-07)
In this study, the stability of 124 target analytes in influent and effluent wastewater samples during short-term (4°C) and long-term (-18°C) storage was assessed. The most common storage scenario was considered, in which samples were frozen immediately after sampling without
Sang Yoon Lee et al.
Toxicology letters, 229(1), 33-40 (2014-06-10)
Although cytochrome P450 inhibition is the major drug-drug interaction (DDI) mechanism in clinical pharmacotherapy, DDI of a number of well-established drugs have not been investigated. Rifampicin, isoniazid, pyrazinamide and ethambutol combination therapy inhibits clearance of theophylline in patients with tuberculosis.
Pharmacology for the Primary Care Provider (2008)
Ji-Yoon Lee et al.
Chemico-biological interactions, 229, 109-118 (2015-01-28)
We investigated to compare species differences in amitriptyline (AMI) metabolism among mouse, rat, dog, and human liver microsomes. We developed a method for simultaneous determination of metabolic stability and metabolite profiling using predictive multiple reaction monitoring information-dependent acquisition-enhanced product ion
Maria K Swarcewicz et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(6), 1396-1402 (2013-03-20)
Carbamazepine (CBZ), nonbiodegradable pharmaceutical residue, has become an emerging pollutant in several aquatic environments. The effectiveness of the mixture of soil and fly ash (FA) in adsorbing CBZ from aqueous solution has been studied as well as agitation time, FA
Martina Fanella et al.
Epileptic disorders : international epilepsy journal with videotape, 15(2), 181-187 (2013-06-19)
Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be underdiagnosed or misdiagnosed; in the latter case, it may be mistaken for
Yousheng Xiao et al.
The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20)
The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual field defects. Whether VGB monotherapy is an effective
Yasuhiro Horita et al.
Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)
Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated
Jacek Wójcikowski et al.
Pharmacological reports : PR, 66(6), 1122-1126 (2014-12-03)
Joint administration of phenothiazine neuroleptics and an antidepressant or carbamazepine is applied in the therapy of many complex psychiatric disorders. The aim of the present study was to investigate possible effects of the tricyclic antidepressant drug amitriptyline and the anticonvulsant
Yin-Bo Chen et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 15(5), 340-342 (2013-05-17)
To investigate the clinical efficacy and safety of oxcarbazepine (OXC) suspension in children with focal epilepsy. A total of 118 children aged 2-14 years, who were newly diagnosed with focal epilepsy between October 2009 and December 2011, were randomly divided
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