PHR1072

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Showing 1-30 of 791 results for "PHR1072" within Papers

Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS).

Marie W Pettit et al.

International journal of pharmaceutics, 468(1-2), 264-271 (2014-04-01)

An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15% (w/v)) over

RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents.

Xuemin Qian et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(5), 343-361 (2015-03-22)

Chronic pulmonary inflammation has been consistently shown to increase the risk of lung cancer. Therefore, assessing the molecular links between the two diseases and identification of chemopreventive agents that inhibit inflammation-driven lung tumorigenesis is indispensable. Female A/J mice were treated

The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome.

Carlos M Laborde et al.

Proteome science, 12, 43-43 (2014-01-01)

Acute coronary syndrome is the major cause of death in developed countries. Despite its high prevalence, there is still a strong need for new biomarkers which permit faster and more accurate diagnostics and new therapeutic drugs. The basis for this

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: a comparative study.

Davy Baudelet et al.

Journal of chromatography. A, 1363, 257-269 (2014-07-21)

Analytical enantioseparation of three pyroglutamide derivatives with pharmacological activity against the purinergic receptor P2X7, was run in both high-performance liquid chromatography and supercritical fluid chromatography. Four polysaccharide based chiral stationary phases, namely amylose and cellulose tris (3,5-dimethylphenylcarbamate), amylose tris ((S)-α-methylbenzylcarbamate)

Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway.

Julia E Rager et al.

International journal of molecular sciences, 15(12), 22374-22391 (2014-12-06)

There is increasing evidence that environmental agents mediate susceptibility to infectious disease. Studies support the impact of prenatal/early life exposure to the environmental metals inorganic arsenic (iAs) and cadmium (Cd) on increased risk for susceptibility to infection. The specific biological

Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry.

Marcos Tascon et al.

Analytical and bioanalytical chemistry, 407(13), 3637-3645 (2015-03-10)

The use of algae as a foodstuff is rapidly expanding worldwide from the East Asian countries, where they are also used for medical care. Harmala alkaloids (HAlk) are a family of bioactive compounds found in the extracts of some plants

Use of a human skin in vitro model to investigate the influence of 'every-day' clothing and skin surface decontamination on the percutaneous penetration of organophosphates.

C A Moore et al.

Toxicology letters, 229(1), 257-264 (2014-06-10)

Organophosphates (OPs) are widely used in agriculture. Many studies have investigated the capability of personal protective equipment (PPE) to reduce chemical exposure; however, investigations into the protective effect of 'every-day' clothing are rare. The purpose of this study was to

Proteogenomics analysis reveals specific genomic orientations of distal regulatory regions composed by non-canonical histone variants.

Kyoung-Jae Won et al.

Epigenetics & chromatin, 8, 13-13 (2015-04-17)

Histone variants play further important roles in DNA packaging and controlling gene expression. However, our understanding about their composition and their functions is limited. Integrating proteomic and genomic approaches, we performed a comprehensive analysis of the epigenetic landscapes containing the

Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase.

Federica Ianni et al.

Journal of chromatography. A, 1363, 101-108 (2014-04-15)

While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this

Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study.

Paul Holvoet et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 77, 22-33 (2015-01-03)

There is a close interaction between Type 2 Diabetes, obesity and liver disease. We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the

Ion mobility spectrometry evaluation of cocaine occupational exposure in forensic laboratories.

Sergio Armenta et al.

Talanta, 130, 251-258 (2014-08-28)

An approach, based on ion mobility spectrometry (IMS) has been developed for the control of cocaine in air of the breathing zone of operators, in laboratory surfaces and in nasal mucus of employees to evaluate cocaine exposure in a forensic

Enhanced separation of Compound Xueshuantong capsule using functionalized carbon nanotubes with cationic surfactant solutions in MEEKC.

Jun Cao et al.

Electrophoresis, 34(2), 324-330 (2012-11-20)

A novel additive of multi-walled carbon nanotubes (MWNTs) dispersed with cationic surfactants or mixed cationic/anionic surfactants was used for MEEKC separation of eight phenolic compounds, four glycosides, and one phenanthraquinone. In this context, several parameters affecting MEEKC separation were studied

Insights into chiral recognition mechanisms in supercritical fluid chromatography V. Effect of the nature and proportion of alcohol mobile phase modifier with amylose and cellulose tris-(3,5-dimethylphenylcarbamate) stationary phases.

Syame Khater et al.

Journal of chromatography. A, 1373, 197-210 (2014-12-09)

In enantioselective supercritical fluid chromatography (SFC) with chiral stationary phases (CSP), the elution strength of carbon dioxide is usually modulated by the use of polar organic solvents, also called modifiers. Alcohols like methanol, ethanol and isopropanol are the most commonly

Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.

Annika Kasten et al.

PloS one, 9(9), e108055-e108055 (2014-09-23)

Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies for tissue engineering.

Effects of tatariside G isolated from Fagopyrum tataricum roots on apoptosis in human cervical cancer HeLa cells.

Yuan Li et al.

Molecules (Basel, Switzerland), 19(8), 11145-11159 (2014-07-31)

Cervical cancer is the second most common female carcinoma. Current therapies are often unsatisfactory, especially for advanced stage patients. The aim of this study was to explore the effects of tatariside G (TG) on apoptosis in human cervical cancer HeLa

A method for the detection of alcohol vapours based on optical sensing of magnesium 5,10,15,20-tetraphenyl porphyrin thin film by an optical spectrometer and principal component analysis.

Sumana Kladsomboon et al.

Analytica chimica acta, 757, 75-82 (2012-12-05)

In this work we have proposed a method for the detection of alcohol vapours, i.e. methanol, ethanol and isopropanol, based on the optical sensing response of magnesium 5,10,15,20-tetraphenyl porphyrin (MgTPP) thin films, as measured by optical spectrometry with the assistance

Thermal degradation of green tea flavan-3-ols and formation of hetero- and homocatechin dimers in model dairy beverages.

Brian J Song et al.

Food chemistry, 173, 305-312 (2014-12-04)

Interactions between polyphenols and macromolecules may impact polyphenol stability and bioavailability from foods. The impact of milk on tea flavan-3-ol stability to thermal treatment was investigated. Single strength (36.2 protein per L), quarter strength (9.0 g protein per L) milk

Use of an enzyme-assisted method to improve protein extraction from olive leaves.

M Vergara-Barberán et al.

Food chemistry, 169, 28-33 (2014-09-23)

The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic solvent, enzyme amount, pH

The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue.

Halina Abramczyk et al.

The Analyst, 140(7), 2224-2235 (2015-03-03)

We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We demonstrate the first application of Raman imaging and spectroscopy in diagnosing the role of lipid droplets in cell line

High-resolution nanotransfer printing applicable to diverse surfaces via interface-targeted adhesion switching.

Jae Won Jeong et al.

Nature communications, 5, 5387-5387 (2014-11-11)

Nanotransfer printing technology offers outstanding simplicity and throughput in the fabrication of transistors, metamaterials, epidermal sensors and other emerging devices. Nevertheless, the development of a large-area sub-50 nm nanotransfer printing process has been hindered by fundamental reliability issues in the replication

Sara Tomei et al.

Molecular oncology, 9(1), 93-104 (2014-09-02)

The existence of a dichotomy between immunologically active and quiescent tumor phenotypes has been recently recognized in several types of cancer. The activation of a Th1 type of immune signature has been shown to confer better prognosis and likelihood to

Transcriptional analysis of South African cassava mosaic virus-infected susceptible and tolerant landraces of cassava highlights differences in resistance, basal defense and cell wall associated genes during infection.

Farhahna Allie et al.

BMC genomics, 15, 1006-1006 (2014-11-22)

Cassava mosaic disease is caused by several distinct geminivirus species, including South African cassava mosaic virus-[South Africa:99] (SACMV). To date, there is limited gene regulation information on viral stress responses in cassava, and global transcriptome profiling in SACMV-infected cassava represents

Evaluation of five antifungal agents used in remediation practices against six common indoor fungal species.

P Chakravarty et al.

Journal of occupational and environmental hygiene, 10(1), D11-D16 (2012-12-01)

HPLC-DAD evidence of the oscillatory chiral conversion of phenylglycine.

Mieczysław Sajewicz et al.

Journal of chromatographic science, 52(4), 329-333 (2013-04-11)

Previous studies by the authors have used thin-layer chromatography to demonstrate the ability of chiral low molecular weight carboxylic acids to undergo spontaneous oscillatory chiral conversion in abiotic (aqueous and nonaqueous) solutions. General mechanisms of this conversion were proposed, taking

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.

Zhiguo Zhang et al.

Journal of molecular and cellular cardiology, 77, 42-52 (2014-10-01)

Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate naturally presenting in widely consumed vegetables, particularly broccoli, plays an important role in cardiac protection from diabetes. We investigated the effect

Transient and persistent metabolomic changes in plasma following chronic cigarette smoke exposure in a mouse model.

Charmion I Cruickshank-Quinn et al.

PloS one, 9(7), e101855-e101855 (2014-07-10)

Cigarette smoke exposure is linked to the development of a variety of chronic lung and systemic diseases in susceptible individuals. Metabolomics approaches may aid in defining disease phenotypes, may help predict responses to treatment, and could identify biomarkers of risk

Exploring the enantioseparation of amino-naphthol analogues by supercritical fluid chromatography.

Anita Aranyi et al.

Journal of chromatography. A, 1387, 123-133 (2015-02-18)

The direct separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol, 2-(α-aminoarylmethyl)-1-naphthol analogues and 2-(1-amino-2-methylpropyl)-1-naphthol) was investigated in supercritical fluid chromatography. Five commercially available chiral stationary phases based on immobilized polysaccharide chiral selectors (Chiralpak IA, IB, IC, ID and IE) were evaluated.

Cilengitide--exceptional pseudopolymorphism of a cyclic pentapeptide.

C Saal et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 1-11 (2015-02-15)

Cilengitide (Cil) represents a cyclic pentapeptide, cyclo-(Arg-Gly-Asp-D-Phe-N-MeVal). Existence of an anhydrate form (A1) and a tetrahydrate form Cil1(H2O)4 has been observed. Surprisingly the anhydrate form proved to be more stable in aqueous environment compared to the tetrahydrate form. Assessment of

Metabolic alterations, HFE gene mutations and atherogenic lipoprotein modifications in patients with primary iron overload.

Tomás Meroño et al.

Clinical science (London, England : 1979), 128(9), 609-618 (2014-12-03)

Iron overload (IO) has been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is associated with mutations in the HFE gene. To which extent HFE gene mutations and metabolic alterations contribute to the presence

Using SILAC proteomics to investigate the effect of the mycotoxin, alternariol, in the human H295R steroidogenesis model.

Shewit Kalayou et al.

Cell biology and toxicology, 30(6), 361-376 (2014-11-25)

The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable

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