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Showing 1-30 of 86 results for "PHR1075" within Papers
Wei Guo et al.
Environmental toxicology and pharmacology, 38(3), 901-912 (2014-12-03)
This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of
Xiaofeng Bao et al.
Nuclear medicine and biology, 39(8), 1128-1136 (2012-08-18)
Rhodamine-123 is a known substrate for the efflux transporter, P-glycoprotein (P-gp). We wished to assess whether rhodamine-123 might serve as a useful substrate for developing probes for imaging efflux transporters in vivo with positron emission tomography (PET). For this purpose
Hong Wei et al.
Pharmacological research, 90, 58-66 (2014-10-12)
Among brain structures receiving efferent projections from the histaminergic tuberomammillary nucleus is the pontine locus coeruleus (LC) involved in descending noradrenergic control of pain. Here we studied whether histamine in the LC is involved in descending regulation of neuropathic hypersensitivity.
Noah Scheinfeld
Dermatology online journal, 9(2), 4-4 (2003-03-18)
Cimetidine, approved by the FDA for inhibition of gastric acid secretion, has been advocated for a number of dermatological diseases. The cutaneous uses and immunological effects of cimetidine have been actively studied over the past few years, and this review
Tzu-Kai Lin et al.
The Journal of investigative dermatology, 133(2), 469-478 (2012-09-28)
Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes express
Jamie Merves et al.
PloS one, 10(2), e0114831-e0114831 (2015-02-28)
Eosinophilic Esophagitis (EoE) is a chronic allergic disorder, whose pathobiology is incompletely understood. Histamine-producing cells including mast cells and basophils have been implicated in EoE. However, very little is currently known about the role of histamine and histamine receptor (HR)
P D Rogers
The Annals of pharmacotherapy, 31(3), 365-367 (1997-03-01)
Treatment options for AIP remain limited. Although no single therapy has been proven superior in clinical trials, intravenous hemin appears to be more effective than increased carbohydrate intake, and remains the treatment of choice. At usual dosages the average wholesale
Fatmanur Tuğcu-Demiröz et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 105-110 (2014-06-03)
The aim of the present study was to develop a method for water flux reabsorption measurement in Doluisio's Perfusion Technique based on the use of phenol red as a non-absorbable marker and to validate it by comparison with gravimetric procedure.
Jaclyn N Harper et al.
American journal of physiology. Renal physiology, 304(1), F56-F67 (2012-10-05)
OCT2 is the entry step for organic cation (OC) secretion by renal proximal tubules. Although many drugs inhibit OCT2 activity, neither the mechanistic basis of their inhibition nor their transport status is generally known. Using representatives of several structural classes
Rieko Oshima et al.
Metabolism: clinical and experimental, 64(2), 296-304 (2014-12-01)
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key molecule of metabolic enhancement in skeletal muscle. We investigated whether metformin (MET) acts directly on skeletal muscle, is transported into skeletal muscle via organic cation transporters (OCTs), and activates AMPK. Isolated rat
Swati Dumitras et al.
International journal of clinical pharmacology and therapeutics, 51(10), 771-779 (2013-09-18)
Glycopyrronium (NVA237), a novel once-daily long-acting muscarinic antagonist (LAMA), has recently been approved for maintenance treatment of COPD. This study evaluated the effect of organic cation transporter inhibition on inhaled glycopyrronium disposition using cimetidine as a probe inhibitor. In this
Florence Lefranc et al.
International journal of oncology, 28(5), 1021-1030 (2006-04-06)
Cimetidine (CIM), the prototypical histamine H2 receptor antagonist (H2RA), was brought to market based on its ability to accelerate healing of gastrointestinal ulcers through the inhibition of gastric acid secretion. Cimetidine, the most studied H2RA, has been demonstrated to possess
G I Lobov et al.
Bulletin of experimental biology and medicine, 152(4), 406-408 (2012-07-18)
The effects of histamine and mechanisms of its action on the capsular smooth muscle cells of mesenteric lymph nodes were examined on isolated capsular strips under isometric conditions. Histamine (1×10(-8)-5×10(-7) M) decreased the tone of capsular smooth muscle cells and
Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice.
Naoki Ito et al.
Journal of pharmaceutical sciences, 103(10), 3342-3348 (2014-09-02)
Drug transfer into milk is a general concern during lactation. So far, breast cancer resistance protein (Bcrp) is the only transporter known to be involved in this process, whereas participation of other transporters remains unclear. We investigated the importance of
Ulcerogenic and intestinal motility/transit stimulating actions of nevirapine in albino Wistar rats.
Elizabeth Bassey Umoren et al.
Journal of physiology and biochemistry, 69(3), 547-557 (2013-03-29)
The antiretroviral is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. This study was undertaken to investigate the effect of nevirapine (NVP) administration on gastric acid secretion, pepsin secretion, mucosal secretion, intestinal motility, and transit using apparently
Sanjeev Deva et al.
The Cochrane database of systematic reviews, 8(8), CD007814-CD007814 (2012-08-17)
Anecdotal reports of tumour regression with histamine type 2 receptor antagonists (H(2)RAs) have lead to a series of trials with this class of drug as adjuvant therapy to try and improve outcomes in patients with resected colorectal cancers. There was
Tonggui Ding et al.
Basic & clinical pharmacology & toxicology, 116(5), 385-389 (2014-09-25)
This study firstly investigated the effects of cucurbitacin E (CuE), a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics (PK) and pharmacodynamics (PD) of warfarin, a model CYP2C probe substrate, in the rat. In PK studies, the concentration of warfarin
Margaret O Sofidiya et al.
BMC complementary and alternative medicine, 12, 168-168 (2012-10-04)
The leaves and root of Flabellaria paniculata (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and
Jia-Xing Yue et al.
CNS neuroscience & therapeutics, 20(10), 883-892 (2014-07-06)
The upregulation of Nav1.8 in primary afferents plays a critical role in the development and persistence of neuropathic pain. The mechanisms underlying the upregulation are not fully understood. The present study aims to investigate the regulatory effect of histamine on
J A Sprowl et al.
Clinical pharmacology and therapeutics, 94(5), 585-592 (2013-07-19)
The organic cation transporter 2 (OCT2) regulates uptake of cisplatin in proximal tubules, and inhibition of OCT2 protects against severe cisplatin-induced nephrotoxicity. However, it remains uncertain whether potent OCT2 inhibitors, such as cimetidine, can influence the antitumor properties and/or disposition
C E Elwin
Nordisk medicin, 106(5), 151-154 (1991-01-01)
Interactions between pharmaceutical preparations are common and can occur at almost every stage in a substance's metabolic clearance but frequently lack clinical significance. Different factors must be considered in the assessment of data on interactions. This article compares interactions between
Bo-lin Liu et al.
Journal of neurosurgery, 118(1), 115-120 (2012-10-16)
Patients with intracerebral hemorrhage (ICH) are at high risk for severe stress-related upper gastrointestinal (UGI) bleeding, which is predictive of higher mortality. The aim of this study was to evaluate the effectiveness of omeprazole and cimetidine compared with a placebo
Victoria M Bajo et al.
The European journal of neuroscience, 40(6), 2922-2940 (2014-06-20)
Cholinergic inputs to the auditory cortex can modulate sensory processing and regulate stimulus-specific plasticity according to the behavioural state of the subject. In order to understand how acetylcholine achieves this, it is essential to elucidate the circuitry by which cholinergic
L N Valenkevich et al.
Klinicheskaia meditsina, 69(3), 91-93 (1991-03-01)
The response of serum gastrin, insulin and glucagon to administration of sodium bicarbonate (SB) followed by cimetidine was studied in 35 duodenal ulcer patients. Relevant measurements were made using radioimmunoassay kits "Diagnostic" (USA) and "Oris" (France). It was established that
Martin E Edelsbrunner et al.
BMC gastroenterology, 9, 40-40 (2009-06-06)
Lafutidine is a histamine H2 receptor antagonist, the gastroprotective effect of which is related to its antisecretory activity and its ability to activate a sensory neuron-dependent mechanism of defence. The present study investigated whether intragastric administration of lafutidine (10 and
C Balraj et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 114, 256-266 (2013-06-19)
For the first time, the charge transfer (CT) complexes of quinones in aqueous medium have been reported. A series of novel water soluble 1,4-benzoquinones possessing variable number of chloro and methoxy substituents has been employed as electron acceptors (MQ1-4) in
Flávia L Beltrame et al.
Histology and histopathology, 27(10), 1343-1351 (2012-09-01)
Cimetidine, an H₂ receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing apoptosis in the myoid cells. Regarding the importance of histamine and androgens
Lucy C Stott et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 127-137 (2014-12-30)
The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that
Boyou Li et al.
Hepato-gastroenterology, 60(122), 244-247 (2012-09-05)
Cimetidine has been shown to play an important role in the treatment of cancer and the regulation of the immune system. Therefore, we aimed to observe the effects of cimetidine on the systematic immune response in the perioperative period. Sixty
R D Evans et al.
Clinics in podiatric medicine and surgery, 17(2), 371-375 (2000-05-16)
Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy. Although its usage has gained popularity because it offers an alternative to conventional topical and surgical verruca therapy, its reported efficacy in managing warts
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