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Showing 1-30 of 353 results for "PHR1138" within Papers
Emina M Mrkalić et al.
Dalton transactions (Cambridge, England : 2003), 43(40), 15126-15137 (2014-09-02)
Novel palladium complexes, KH[Pd(obap)]2·3H2O (3) with oxamido-N-aminopropyl-N'-benzoic acid and [Pd(apox)] (4) with N,N'-bis(3-aminopropyl)ethanediamide, were synthesized. Exhaustive synthetic, solution and structural studies of the two Pd(ii) complexes are reported. The binary and ternary systems of the Pd(ii) ion with H2apox or
Inefficacy of platelet transfusion to reverse ticagrelor.
Anne Godier et al.
The New England journal of medicine, 372(2), 196-197 (2015-01-08)
James A Birrell et al.
Biochemistry, 52(23), 4048-4055 (2013-05-21)
NADH:ubiquinone oxidoreductase (complex I) is a complicated respiratory enzyme that conserves the energy from NADH oxidation, coupled to ubiquinone reduction, as a proton motive force across the mitochondrial inner membrane. During catalysis, NADH oxidation by a flavin mononucleotide is followed
A Marechal et al.
Journal of chromatography. A, 1365, 140-147 (2014-09-25)
This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a "generic" vinyl-functionalized silica monolith (Hmin 6±1μm). The photoclick reaction is investigated using different thiol monomers (octadecanethiol, cysteine
Ronald F Parsons et al.
Current opinion in organ transplantation, 19(2), 100-107 (2014-02-21)
To update the reader on the recent literature in liver, kidney, pancreas, and intestine static cold preservation, and to identify which solutions are most advantageous for each organ. The comparison of randomized trials of histidine-tryptophan-ketoglutarate (HTK), Celsior, and University of
Nehal M Elsherbiny et al.
Biochemical and biophysical research communications, 436(3), 355-361 (2013-05-21)
The early activation of microglia that induces retinal inflammation in DR may serve as a target for therapeutic intervention of DR. Our demonstration that retinal inflammation is attenuated via adenosine receptor A(2A)AR supports the hypothesis that a mechanism to maintain
Guadalupe-Elide Morales-Figueroa et al.
ACS chemical neuroscience, 5(8), 637-645 (2014-06-03)
High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve terminals (synaptosomes), we studied whether H3R
Aniruddha J Deshpande et al.
Cancer cell, 26(6), 896-908 (2014-12-04)
Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We
Nobukiyo Tanaka et al.
Clinical cardiology, 38(1), 20-24 (2015-01-30)
Fractional flow reserve (FFR) is useful for determining the functional significance of epicardial coronary stenosis and may facilitate clinical decision making in patients with an equivocal coronary stenosis for coronary revascularization. Therefore, determining an efficient and safe method to achieve
Aleksander Araszkiewicz et al.
Cardiology, 129(4), 250-257 (2014-11-18)
Postconditioning has been reported to reduce infarct size in ST-segment myocardial infarction (STEMI). However, recently, few other studies did not show any effect of postconditioning and suggested that it may be even harmful. We sought to assess whether postconditioning could
Soroush T Sarvestani et al.
Journal of virology, 88(2), 799-810 (2013-11-15)
RNA-specific adenosine deaminase (ADAR)-mediated adenosine-to-inosine (A-to-I) editing is a critical arm of the antiviral response. However, mechanistic insights into how A-to-I RNA editing affects viral infection are lacking. We posited that inosine incorporation into RNA facilitates sensing of nonself RNA
Bijay Kumar Jha et al.
Parasitology research, 114(3), 1189-1195 (2015-01-08)
Acanthamoeba is an opportunistic protozoan parasite responsible for different diseases in humans, such as granulomatous amoebic encephalitis and amoebic keratitis. Tigecycline, a third-generation tetracycline antibiotic, has potential activity to treat most of the antibiotic resistant bacterial infections. The effects of
Streptococcus suis adenosine synthase functions as an effector in evasion of PMN-mediated innate immunit.
Liu P, Pian Y, Li X, et al.
The Journal of Infectious Diseases, 210(1), 35-45 (2014)
Luca Antonioli et al.
Nature reviews. Cancer, 13(12), 842-857 (2013-11-15)
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic processes. Adenosine is an ancient extracellular signalling molecule that can regulate almost all aspects of tissue function. As such, several studies have recently highlighted a crucial
David Garcia-Dorado et al.
International journal of cardiology, 177(3), 935-941 (2014-12-03)
The effect of intracoronary adenosine (ADO) on ST-segment elevation myocardial infarction (STEMI) size and adverse remodeling is not well established. In a double-blind trial, 201 patients with STEMI were randomized to receive percutaneous coronary intervention (PCI) within 6 hours of
Nehal M Elsherbiny et al.
Life sciences, 93(2-3), 78-88 (2013-06-19)
This study was undertaken to determine the effect of an adenosine kinase inhibitor (AKI) in diabetic retinopathy (DR). We have shown previously that adenosine signaling via A2A receptors (A2AAR) is involved in retinal protection from diabetes-induced inflammation. Here we demonstrate
Ticagrelor (Brilinta) for secondary prevention of thrombotic events following acute coronary syndrome.
Katrina Tsang et al.
American family physician, 88(12), 821-822 (2013-12-25)
Joanna Mattis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(35), 11769-11780 (2014-08-29)
Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to also play an important role in
Saiid Bina et al.
Critical care medicine, 43(3), 584-593 (2014-12-06)
Malignant hyperthermia is a pharmacogenetic disorder typically triggered by potent inhalation anesthetics and/or the depolarizing muscle relaxant succinylcholine in malignant hyperthermia-susceptible individuals. Since lymphocytes express the same Ca channel mutation found in malignant hyperthermia-susceptible muscle, we investigated agonist-induced adenosine formation
Maria J Pereira et al.
Metabolism: clinical and experimental, 63(9), 1198-1208 (2014-07-07)
To study effects of dexamethasone on gene expression in human adipose tissue aiming to identify potential novel mechanisms for glucocorticoid-induced insulin resistance. Subcutaneous and omental adipose tissue, obtained from non-diabetic donors (10 M/15 F; age: 28-60 years; BMI: 20.7-30.6 kg/m²)
Saif Ahmad et al.
Journal of neuroimmunology, 277(1-2), 96-104 (2014-12-03)
Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of
Shari L Wiseman et al.
The Journal of biological chemistry, 288(24), 17803-17811 (2013-05-04)
Protein translation and degradation are critical for proper protein homeostasis, yet it remains unclear how these processes are dynamically regulated, or how they may directly balance or synergize with each other. An important translational control mechanism is the Ca(2+)/calmodulin-dependent phosphorylation
Liming Wu et al.
Food chemistry, 173, 1111-1118 (2014-12-04)
Nucleotides, nucleosides and nucleobases play a greater role in the physiological activity of organisms which are highly present in royal jelly (RJ). The objective of the present study is to develop a HPLC method to simultaneous determine nucleotides, nucleosides and
Physiological assessment of nonculprit stenoses during acute coronary syndromes.
Tim P van de Hoef et al.
The American journal of cardiology, 114(3), 496-496 (2014-07-16)
Xiao Wang et al.
Nature, 505(7481), 117-120 (2013-11-29)
N(6)-methyladenosine (m(6)A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m(6)A modification remains to be determined. The recent discovery of two
Tobias Heer et al.
American heart journal, 166(6), 999-1009 (2013-11-26)
We sought to evaluate the diagnostic performance of 1.5-T non-contrast enhanced whole-heart magnetic resonance coronary angiography (MRCA) alone and in combination with adenosine stress cardiac magnetic resonance imaging (CMR-Perf). MRCA has been proposed to allow for detection of coronary artery
Rafael Perígolo-Vicente et al.
Biochemical and biophysical research communications, 449(4), 477-482 (2014-05-23)
Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to
Hana Vlčková et al.
Journal of separation science, 37(11), 1297-1307 (2014-03-22)
The retention behavior of a large group of analytes (35) with varied properties (pKa and logP) was studied on eight hydrophilic interaction LC columns with different surfaces, stationary phase chemistries, and types of particles. The acetonitrile content (5-95%), buffer concentration
Schraga Schwartz et al.
Cell, 155(6), 1409-1421 (2013-11-26)
N(6)-methyladenosine (m(6)A) is the most ubiquitous mRNA base modification, but little is known about its precise location, temporal dynamics, and regulation. Here, we generated genomic maps of m(6)A sites in meiotic yeast transcripts at nearly single-nucleotide resolution, identifying 1,308 putatively
M Cecati et al.
Journal of biological regulators and homeostatic agents, 27(2), 519-529 (2013-07-09)
The interactions taking place between mother and embryo have been the focus of detailed studies in recent years, where pregnancy is considered as an in vivo transplant. The immune systems of the mother and the embryo together establish a condition
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