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Showing 1-30 of 353 results for "PHR1138" within Papers
T K Greene et al.
Journal of thrombosis and haemostasis : JTH, 12(12), 2102-2112 (2014-10-08)
Ectopically expressed B-domainless factor VIII in megakaryocytes is stored in α-granules, is effective in a number of murine hemostatic models, and is protected from circulating inhibitors. However, this platelet (p) FVIII has different temporal-spatial availability from plasma FVIII, with limited efficacy
Joseph P Gerdt et al.
ACS chemical biology, 9(10), 2291-2299 (2014-08-12)
The growing threat of antibiotic resistance necessitates the development of novel antimicrobial therapies. Antivirulence agents that target group-beneficial traits in microorganisms (i.e., phenotypes that help the cells surrounding the producer cell instead of selfishly benefiting only the producer cell) represent
Yuanhong Shan et al.
Journal of chromatography. A, 1375, 101-109 (2014-12-17)
To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhedral-oligomeric-silsesquioxane-type (POSS) cross-linking agent and the home-made
Christian D Laourdakis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 127-133 (2014-08-05)
Targeted metabolite profiling has aided in the understanding of a variety of biological processes in the malaria parasite as well as in drug discovery. A fast and sensitive analytical method, based on ion-pairing reversed phase ultra-high performance liquid chromatography tandem
Valeria Quarona et al.
Annals of the New York Academy of Sciences, 1335, 10-22 (2014-07-23)
The bone marrow provides a protected environment for generating a vast array of cell types. Bones are thus a dynamic source of structural components and soluble factors used either locally or at a distance from their site of production. We
Andreas Brunschweiger et al.
ChemMedChem, 9(8), 1704-1724 (2014-05-13)
8-Benzyl-substituted tetrahydropyrazino[2,1-f]purinediones were designed as tricyclic xanthine derivatives containing a basic nitrogen atom in the tetrahydropyrazine ring to improve water solubility. A library of 69 derivatives was prepared and evaluated in radioligand binding studies at adenosine receptor (AR) subtypes and
Marianna Sholokh et al.
The journal of physical chemistry. B, 119(6), 2585-2595 (2014-10-14)
Fluorescent amino acids bearing environment-sensitive fluorophores are highly valuable tools for site-selective probing of peptide/ligand interactions. Herein, we synthesized a fluorescent l-amino acid bearing the 4'-methoxy-3-hydroxyflavone fluorophore (M3HFaa) that shows dual emission, as a result of an excited state intramolecular
Mark J Wall et al.
Journal of neurophysiology, 113(3), 871-882 (2014-11-14)
Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can
Farnaz Zahedifard et al.
PLoS neglected tropical diseases, 8(3), e2751-e2751 (2014-03-29)
Novel vaccination approaches are needed to prevent leishmaniasis. Live attenuated vaccines are the gold standard for protection against intracellular pathogens such as Leishmania and there have been new developments in this field. The nonpathogenic to humans lizard protozoan parasite, Leishmania
Shikha Mahajan et al.
PloS one, 10(2), e0115644-e0115644 (2015-02-12)
Proteomics is a powerful approach used for investigating the complex molecular mechanisms of disease pathogenesis and progression. An important challenge in modern protein profiling approaches involves targeting of specific protein activities in order to identify altered molecular processes associated with
Ngueguim Tsofack Florence et al.
Pakistan journal of pharmaceutical sciences, 26(3), 537-545 (2013-04-30)
The present study examine the in vivo effects of Dorstenia Picta (D. picta) on urinary volume and sodium excretion in streptozotocin-induced diabetic rats, and determine a possible mechanism by which the extract increased sodium transport in A6 cells monolayers. Administration
Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases (2006)
Daniel F Martins et al.
Journal of neuroscience research, 93(1), 157-166 (2014-08-01)
Water immersion is widely used in physiotherapy and might relieve pain, probably by activating several distinct somatosensory modalities, including tactile, pressure, and thermal sensations. However, the endogenous mechanisms behind this effect remain poorly understood. This study examined whether warm water
Justyna Kusek et al.
Molecular pharmacology, 87(1), 39-51 (2014-10-31)
Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-adenosine receptor as a sensor to explore
Xu Jing et al.
Journal of the American Chemical Society, 137(11), 3967-3974 (2015-03-05)
The design of artificial systems that mimic highly evolved and finely tuned natural photosynthetic systems is a subject of intensive research. We report herein a new approach to constructing supramolecular systems for the photocatalytic generation of hydrogen from water by
Sandip Kumar Nandi et al.
PLoS neglected tropical diseases, 9(3), e0003661-e0003661 (2015-03-27)
Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic
Asger Granfeldt et al.
Critical care medicine, 42(5), e329-e344 (2014-02-22)
Currently, there is no effective small-volume fluid for traumatic hemorrhagic shock. Our objective was to translate small-volume 7.5% NaCl adenosine, lidocaine, and Mg hypotensive fluid resuscitation from the rat to the pig. Pigs (35-40 kg) were anesthetized and bled to
David Lu et al.
American journal of physiology. Cell physiology, 306(9), C779-C788 (2013-12-20)
Tissue fibrosis occurs as a result of the dysregulation of extracellular matrix (ECM) synthesis. Tissue fibroblasts, resident cells responsible for the synthesis and turnover of ECM, are regulated via numerous hormonal and mechanical signals. The release of intracellular nucleotides and
Carlo Nicola De Cecco et al.
AJR. American journal of roentgenology, 203(1), W70-W77 (2014-06-22)
The purpose of this article is to prospectively determine the value of stress dual-energy CT (DECT) myocardial perfusion imaging to coronary CT angiography (CTA) for the assessment of coronary artery disease (CAD) in a high-risk population. We prospectively enrolled 29
Keizo Kohno et al.
Journal of inflammation (London, England), 12(1), 2-2 (2015-01-30)
Adenosine is a potent endogenous anti-inflammatory and immunoregulatory molecule. Despite its promise, adenosine's extremely short half-life in blood limits its clinical application. Here, we examined adenosine N1-oxide (ANO), which is found in royal jelly. ANO is an oxidized product of
L Baron et al.
Cell death & disease, 6, e1629-e1629 (2015-02-06)
The NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the innate immune system, but its mechanism of activation by a wide range of molecules remains largely unknown. Widely used nano-sized inorganic metal oxides such as silica
Antonella Montinaro et al.
Pharmacological research, 76, 34-40 (2013-07-17)
Melanoma is one of the most aggressive types of cancer, that is difficult to manage clinically. A major feature of melanoma cells is their ability to escape immune surveillance. Adenosine receptors play a pivotal role in host immune-surveillance. A2a (A2aR)
X Gao et al.
European journal of pain (London, England), 18(7), 939-948 (2014-01-08)
Norisoboldine (NOR) is a benzylisoquinoline alkaloid isolated from Radix Linderae, a traditional Chinese medicine. Our previous studies have demonstrated that it produces anti-inflammatory and anti-rheumatoid arthritis effects. The present study was undertaken to explore the analgesic effects of NOR and
V S Mikhaĭlov et al.
Bioorganicheskaia khimiia, 39(1), 81-86 (2013-07-13)
The ability of short peptide nucleic acid (PNA) oligomers and oligonucleotides containing modified residues of 5-methylcitidine, 2-aminoadenosine and 5-propynyl-2'-deoxyuridine (strong binding oligonucleotides, SBO) to affinity capture the target double-stranded DNA fragment from mixture by means of the end invasion was
Tahereh Taheri et al.
Experimental parasitology, 150, 44-55 (2015-02-01)
Because of the lack of an accurate and sensitive tool to evaluate the parasitemia level, treatment or prevention of leishmaniasis remains an important challenge worldwide. To monitor and track leishmanial infection by two parameters in real time, we generated stably
Casey E O'Neill et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 813-821 (2014-10-21)
Caffeine is the most commonly used psychoactive substance, and consumption by adolescents has risen markedly in recent years. We identified the effects of adolescent caffeine consumption on cocaine sensitivity and determined neurobiological changes within the nucleus accumbens (NAc) that may
Marie Tosolini et al.
Molecular and cellular biology, 35(2), 479-495 (2014-11-12)
Cyclic dinucleotides are important messengers for bacteria and protozoa and are well-characterized immunity alarmins for infected mammalian cells through intracellular binding to STING receptors. We sought to investigate their unknown extracellular effects by adding cyclic dinucleotides to the culture medium
Medardo Hernández et al.
British journal of pharmacology, 157(8), 1463-1473 (2009-07-01)
As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of the bladder outflow region, this study investigates the possible release of ATP or related purines in response to electrical field stimulation (EFS) and the purinoceptor(s) involved in nerve-mediated relaxations
Víctor López Del Amo et al.
Human molecular genetics, 24(1), 21-36 (2014-08-15)
One of the genes involved in Charcot-Marie-Tooth (CMT) disease, an inherited peripheral neuropathy, is GDAP1. In this work, we show that there is a true ortholog of this gene in Drosophila, which we have named Gdap1. By up- and down-regulation
Thorsten Gnad et al.
Nature, 516(7531), 395-399 (2014-10-16)
Brown adipose tissue (BAT) is specialized in energy expenditure, making it a potential target for anti-obesity therapies. Following exposure to cold, BAT is activated by the sympathetic nervous system with concomitant release of catecholamines and activation of β-adrenergic receptors. Because
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