phr1242

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Showing 1-30 of 234 results for "phr1242" within Papers

CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.

Bo Peng et al.

Molecular bioSystems, 11(1), 105-114 (2014-10-18)

The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of

Telmisartan reduces progressive accumulation of cellular amyloid beta and phosphorylated tau with inflammatory responses in aged spontaneously hypertensive stroke resistant rat.

Tomoko Kurata et al.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23(10), 2580-2590 (2014-09-23)

In addition to reducing the level of blood pressure (BP), telmisartan was expected to show the long-term neuroprotective effects preventing accumulation of cellular amyloid beta peptide (Aβ) and phosphorylated tau (pτ) by ameliorating neuroinflammation. We examined effects of telmisartan on

Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure.

H Nørrelund et al.

Journal of internal medicine, 260(1), 11-21 (2006-06-23)

It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism.

A phosphorylation-sensitive tyrosine-tailored magnetic particle for electrochemically probing free organophosphates in blood.

Yanmei Si et al.

The Analyst, 139(21), 5466-5471 (2014-09-02)

A simple, rapid, sensitive, selective, and field-deployable detection protocol has been initially proposed for the early warning and diagnosis of exposure to organophosphates (OPs) by electrochemically monitoring the direct biomarkers of free OPs in blood. Phosphorylation-sensitive tyrosine (Tyr), which was

Protumorigenic role of Timeless in hepatocellular carcinoma.

Nahla Elgohary et al.

International journal of oncology, 46(2), 597-606 (2014-11-19)

The mammalian timeless (TIM) protein interacts with proteins of the endogenous clock and essentially contributes to the circadian rhythm. In addition, TIM is involved in maintenance of chromosome integrity, growth control and development. Thus, we hypothesized that TIM may exert

The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease.

X Li et al.

Journal of internal medicine, 275(4), 418-427 (2013-11-19)

Biochemical changes in the cerebrospinal fluid (CSF) could reflect pathophysiological processes in Alzheimer's disease (AD). However, it is still not clear how these processes correlate with grey matter (GM) volume and microstructural changes in the brain. To assess the relationship

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J D Shoemaker et al.

Journal of chromatography, 562(1-2), 125-138 (1991-01-02)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio

Newly identified minor phosphorylation site threonine-279 of measles virus nucleoprotein is a prerequisite for nucleocapsid formation.

Akihiro Sugai et al.

Journal of virology, 88(2), 1140-1149 (2013-11-08)

Measles virus nucleoprotein is the most abundant viral protein and tightly encapsidates viral genomic RNA to support viral transcription and replication. Major phosphorylation sites of nucleoprotein include the serine residues at locations 479 and 510. Minor phosphorylation residues have yet

Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment.

G Alfredsson et al.

Psychopharmacology, 99(3), 322-327 (1989-01-01)

Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The

An enzymatic route to selenazolines.

Jesko Koehnke et al.

Chembiochem : a European journal of chemical biology, 14(5), 564-567 (2013-03-14)

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme

Dental caries and enamelin haplotype.

C Chaussain et al.

Journal of dental research, 93(4), 360-365 (2014-02-04)

In the literature, the enamelin gene ENAM has been repeatedly designated as a possible candidate for caries susceptibility. Here, we checked whether ENAM variants could increase caries susceptibility. To this aim, we sequenced coding exons and exon-intron boundaries of ENAM

Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation.

Chi-Wen Chou et al.

Drug design, development and therapy, 8, 1577-1584 (2014-10-07)

Bamboo is distributed worldwide, and its different parts are used as foods or as a traditional herb. Recently, antitumoral effects of bamboo extracts on several tumors have been increasingly reported; however, antitumoral activity of bamboo extracts on osteosarcoma remains unclear.

Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.

Dong-wang Zhu et al.

Cancer letters, 356(2 Pt B), 773-780 (2014-12-03)

The aim of this study is to eliminate more cancer cells by promoting them from quiescence into cell cycle or by changing their molecular events, leading them to be sensitive to radiation or chemotherapy. Protein phosphatase 2A plays an important

Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1.

Hannieh Sotoud et al.

Naunyn-Schmiedeberg's archives of pharmacology, 388(3), 283-293 (2014-11-25)

Phosphatase inhibitor-1 (I-1) inhibits the catalytic subunit of protein phosphatase type 1 (PP1c) in its protein kinase A (PKA)-phosphorylated form (I-1(P)). It thereby amplifies PKA signaling, which, in the heart, mediates both beneficial (acute) and adverse (chronic) effects of catecholamines.

Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.

Heath D Schmidt et al.

Addiction biology, 20(2), 285-296 (2014-02-11)

Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of accumbens core mGluR1, mGluR5 and protein kinase C (PKC) in

Prediction of serine/threonine phosphorylation sites in bacteria proteins.

Zhengpeng Li et al.

Advances in experimental medicine and biology, 827, 275-285 (2014-11-13)

As a critical post-translational modification, phosphorylation plays important roles in regulating various biological processes, while recent studies suggest that phosphorylation in bacteria is also critical for functional signaling transduction. Since identification of phosphorylation substrates and sites is fundamental for understanding

The anaerobic degradation of L-serine and L-threonine in enterobacteria: networks of pathways and regulatory signals.

G Sawers

Archives of microbiology, 171(1), 1-5 (1998-12-31)

The mechanisms controlling the biosynthesis and degradation of l-serine and l-threonine are remarkably complex. Their metabolism forms a network of pathways linking several amino acids, central primary metabolites such as pyruvate, oxaloacetate and 3-phosphoglycerate, and C1 metabolism. Studies on the

MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.

Adi E Matitau et al.

The Journal of biological chemistry, 288(39), 28293-28302 (2013-08-22)

MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). MEKK2 integrates stress and mitogenic signals to the activation of NF-κB, JNK1/2, p38, and ERK5 pathways. We have found that

Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate.

Dhirendra K Simanshu et al.

Journal of biosciences, 32(6), 1195-1206 (2007-10-24)

In Escherichia coli and Salmonella typhimurium, L-threonine is cleaved non-oxidatively to propionate via 2-ketobutyrate by biodegradative threonine deaminase, 2-ketobutyrate formate-lyase (or pyruvate formate-lyase), phosphotransacetylase and propionate kinase. In the anaerobic condition, L-threonine is converted to the energy-rich keto acid and

Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation.

Heidi Turkia et al.

Talanta, 131, 366-371 (2014-10-05)

The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino

A novel ATP-generating machinery to counter nitrosative stress is mediated by substrate-level phosphorylation.

Christopher Auger et al.

Biochimica et biophysica acta, 1850(1), 43-50 (2014-10-12)

It is well-known that elevated amounts of nitric oxide and other reactive nitrogen species (RNS) impact negatively on the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. These perturbations severely compromise O2-dependent energy production. While bacteria are known to adapt to

Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18.

Yan Liu et al.

FEBS letters, 587(7), 847-853 (2013-02-26)

CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3

Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.

J K Nicholson et al.

The Biochemical journal, 217(2), 365-375 (1984-01-15)

Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of

Roles of serine and threonine residues of mumps virus P protein in viral transcription and replication.

Adrian Pickar et al.

Journal of virology, 88(8), 4414-4422 (2014-02-07)

Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing

[Role of serine/threonine and tyrosine protein phosphatases in command Helix lucorum neurons at the cellular correlate of habituation].

A S Pivovarov et al.

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 256-268 (2013-07-23)

Effects of some inhibitors of serine/threonine and tyrosine protein phosphatases on the depression and spontaneous recovery of the acetylcholine-induced inward current (ACh-current) in command Helix neurons of defensive behavior at the cellular correlate of habituation were investigated. The following drugs

Supplemental glycine and threonine effects on performance, intestinal mucosa development, and nutrient utilization of growing broiler chickens.

I C Ospina-Rojas et al.

Poultry science, 92(10), 2724-2731 (2013-09-21)

A study was conducted to evaluate Gly requirements in low-CP diets with different levels of digestible (dig) Thr, and their effects on performance, intestinal mucosal development, and nutrient utilization of broiler chickens from 21 to 35 d age. A total

Children with severe asthma have unique oxidative stress-associated metabolomic profiles.

Anne M Fitzpatrick et al.

The Journal of allergy and clinical immunology, 133(1), 258-261 (2013-12-29)

Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.

Ma Paz Lorenzo et al.

Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.

Anna Walter et al.

Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).

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