CN
- An enzymatic route to selenazolines.
An enzymatic route to selenazolines.
Chembiochem : a European journal of chemical biology (2013-03-14)
Jesko Koehnke, Falk Morawitz, Andrew F Bent, Wael E Houssen, Sally L Shirran, Matthew A Fuszard, Iain A Smellie, Catherine H Botting, Margaret C M Smith, Marcel Jaspars, James H Naismith
PMID23483642
ABSTRACT
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
L-Threonine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0%
Supelco
L-Threonine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland