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Showing 1-30 of 3291 results for "PHR1372" within Papers
Ragna Berthelsen et al.
International journal of pharmaceutics, 473(1-2), 356-365 (2014-07-06)
The aim of this study was to develop a sensitive and discriminative in vitro-in silico model able to simulate the in vivo performance of three fenofibrate immediate release formulations containing different surfactants. In addition, the study was designed to investigate
Emmanuelle Vulliet et al.
Environmental science and pollution research international, 21(12), 7512-7521 (2014-03-07)
To collect a complete dataset regarding the occurrence of organic substances in groundwater, this study presents the examination of 66 organic contaminants in the groundwater of overseas departments, including pesticides, pharmaceutical compounds, hormones and some industrial substances. The selective and
Paula Solar et al.
Journal of nanobiotechnology, 13, 14-14 (2015-04-18)
Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic iron oxide nanoparticles (SPIONs) are useful for all of these applications, and in
Sivaprakash Ramalingam et al.
Current gene therapy, 14(6), 461-472 (2014-09-24)
Generation and precise genetic correction of patient-derived hiPSCs have great potential in regenerative medicine. Such targeted genetic manipulations can now be achieved using gene-editing nucleases. Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively from
Johanna Krippner et al.
Journal of agricultural and food chemistry, 63(14), 3646-3653 (2015-03-31)
Uptake of perfluoroalkyl acids (PFAAs) by maize represents a potential source of exposure for humans, either directly or indirectly via feed for animals raised for human consumption. The aim of the following study was, therefore, to determine the accumulation potential
Panfeng Yu et al.
Journal of chromatography. A, 1348, 27-33 (2014-05-20)
In this paper, polyethylene glycol modified (PEGylated) magnetic carbon nanotubes were developed as solid-phase extraction nanosorbents for the determination of methylprednisolone in rat plasma. The procedure mainly involved two steps including preparation of PEGylated magnetic nanosorbents and bioanalysis. Monodisperse magnetites
Eva Gorrochategui et al.
Analytica chimica acta, 854, 20-33 (2014-12-07)
A lipidomic study was developed in a human placental choriocarcinoma cell line (JEG-3) exposed to tributyltin (TBT) and to a mixture of perfluorinated chemicals (PFCs). The method was based on the application of multivariate curve resolution-alternating least squares (MCR-ALS) to
Fengxia Wu et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 43-51 (2014-06-30)
We studied the effects of endocrine disrupting compounds nonylphenol (NP) and letrozole (LE) on the male goldfish Carassius aumtus. Exposure to NP (20 μg l(-1)) alone caused a significant up-regulation in the expression of aromatase, estrogen receptors and vitellogenin (VTG)
Valentino Ruggieri et al.
BMC plant biology, 14, 337-337 (2014-12-04)
Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used
Sergey Kosourov et al.
Applied and environmental microbiology, 80(18), 5807-5817 (2014-07-13)
We have investigated two approaches to enhance and extend H2 photoproduction yields in heterocystous, N2-fixing cyanobacteria entrapped in thin alginate films. In the first approach, periodic CO2 supplementation was provided to alginate-entrapped, N-deprived cells. N deprivation led to the inhibition
Yan Zhou et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 107-115 (2014-12-08)
Combination therapies have been investigated to address the current challenges of anti-cancer therapeutics. In particular, a novel paradigm of combination therapy targeting both cancer stem/progenitor cells and bulk tumor cells is promising to improve the long-term therapeutic benefit against prostate
Weihao Wang et al.
Steroids, 95, 51-65 (2015-01-13)
Dioscorea panthaica is a traditional Chinese medicinal herb used in the treatment of various physiological conditions, including cardiovascular disease, gastropathy and hypertension. Steroidal saponins (SS) are the main active ingredients of this herb and have effects on myocardial ischemia and
Jessica A Cottrell et al.
Analytical biochemistry, 469, 34-42 (2014-12-03)
This article describes a new method for extracting RNA, protein, and lipid mediators from a single tissue specimen. Specifically, mouse bone fracture callus specimens were extracted into a single solution that was processed using three different procedures to measure messenger
Ritwika Ray et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(47), 15618-15624 (2014-10-07)
The present article describes novel oxidative protocols for direct esterification of alcohols. The protocols involve successful demonstrations of both "cross" and "self" esterification of a wide variety of alcohols. The cross-esterification proceeds under a simple transition-metal-free condition, containing catalytic amounts
Teresa Ferreira et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 21(1), 2-14 (2014-11-13)
A 16th century liturgical cope belonging to D. Teotónio of Braganza (collection of the Museum of Évora, ME 172/1) was selected for a material study. The cope is made of a variety of materials that include two different types of
D Q Li et al.
Journal of chromatography. A, 1345, 50-56 (2014-05-06)
Xanthine oxidase (XO) can catalyze hypoxanthine and xanthine to generate uric acid and reactive oxygen species (ROS), including superoxide anion radical (O₂(•-)) and hydrogen peroxide. XO inhibitors and free radical scavengers are beneficial to the treatment of gout and many
Chengcheng Peng et al.
Biomedical chromatography : BMC, 29(3), 425-436 (2014-07-22)
Shexiang Baoxin pills (SBP) are a traditional Chinese medicine that are used for treating coronary heart disease. Ginsenosides are the main effective components of SBP, but a comprehensive and deep pharmacokinetic study of ginsenosides in SBP, including multiple dosing and
Chunyong He et al.
Journal of pharmaceutical and biomedical analysis, 109, 150-157 (2015-03-17)
Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown. In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS)
Jung-Chen Su et al.
Carcinogenesis, 35(12), 2807-2814 (2014-10-18)
Regulatory factor X-1 (RFX-1) is a transcription factor that has been linked to negative regulation of tumor progression; however, its biological function and signaling cascades are unknown. Here, we performed several studies to elucidate the roles of RFX-1 in the
Matías Butler et al.
Journal of mass spectrometry : JMS, 50(1), 136-144 (2015-01-21)
A series of 11 pairs of substituted pyrazine N-oxides, differing in the substituent position, were examined using electrospray ionization mass spectrometry (ESI-MS) in order to use spectra to assess the differentiation of positional isomers. For each compound, mass spectra were
Martin Studenovský et al.
Anticancer research, 35(2), 753-757 (2015-02-11)
In the present study, we describe the synthesis and physicochemical properties of a novel pH- and thermoresponsive micellar drug delivery system for an anticancer ellipticinium derivative based on the triblock copolymer poly(ethylene oxide)-block-[tert-butylacrylamide-co-6-(N-methacryloylamino)hexanoic acid hydrazide]-block-poly(ethylene oxide). The system was designed
Shoufang Xu et al.
Journal of chromatography. A, 1350, 23-29 (2014-06-01)
In the present work, double water compatible molecularly imprinted polymers (DWC-MIPs) with water compatible core and hydrophilic polymer brushes were prepared by reversible addition-fragmentation chain transfer precipitate polymerization (RAFTPP) and applied as solid-phase extraction (SPE) sorbent for selective preconcentration and
Kyosuke Kazama et al.
American journal of physiology. Heart and circulatory physiology, 306(12), H1714-H1719 (2014-04-15)
Omentin is a novel adipocytokine expressed in visceral adipose tissue. Secretion and blood concentration of omentin decrease in the obese subjects. We previously demonstrated that omentin is anti-inflammatory in vascular smooth muscle cells (SMCs). While vascular remodeling via migration of
M A García-Sevillano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 75-84 (2015-02-11)
Although mercury (Hg) is an important environmental and occupational pollutant, its toxicological effects, especially in serum and red blood cells (RBCs), have been scarcely studied. A toxicometabolomics workflow based on high resolution mass spectrometry approaches has been applied to investigate
Saori Ishizaka et al.
Journal of equine science, 25(4), 65-72 (2015-01-06)
The effects of probiotics on horses are still controversial. The present study was a randomized, double-blinded, placebo-controlled crossover study designed to evaluate the ability of probiotics to improve intestinal conditions in adult horses. Fermented probiotics were administered to 10 healthy
Yimin Niu et al.
Journal of pharmaceutical and biomedical analysis, 104, 21-30 (2014-12-03)
In our previous study, the daily administration of chotosan (CTS), a Kampo formula consisting of Uncaria and other 10 different crude drugs, ameliorated cognitive deficits in several animal models of dementia including type 2 diabetic db/db mice in a similar
Xiaoyan Liu et al.
Molecular bioSystems, 11(2), 635-646 (2014-12-05)
Estradiol is a major drug used clinically to alleviate osteoporosis, partly through inhibition of the activity of osteoclasts, which play a crucial role in bone resorption. So far, little is known about the effects of estradiol on osteoclast metabolism. In
Peng Zhang et al.
International journal of pharmaceutics, 472(1-2), 185-191 (2014-06-21)
One attractive approach to increase the aqueous solubility and thus the bioavailability of poorly soluble drugs is to formulate them in their amorphous state since amorphous compounds generally exhibit higher apparent solubilities than their crystalline counterparts. In the current work
Seok-Hee Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(6), 1733-1738 (2015-01-28)
Insects impact human health through vector-borne diseases and cause major economic losses by damaging crops and stored agricultural products. Insect-specific growth regulators represent attractive control agents because of their safety to the environment and humans. We identified plant compounds that
Wei Guo et al.
Environmental toxicology and pharmacology, 38(3), 901-912 (2014-12-03)
This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of
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