PHR1418

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Showing 1-30 of 43 results for "PHR1418" within Papers

Improved physicochemical characteristics of artemisinin using succinic acid.

Muhammad Tayyab Ansari et al.

Acta poloniae pharmaceutica, 71(3), 451-462 (2014-10-01)

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due

Optimization and validation of an HPLC-photodiode array detector method for determination of organic acids in vinegar

Zong Y, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 98(2), 422-430 (2015)

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.

Bryce W Carey et al.

Nature, 518(7539), 413-416 (2014-12-10)

The role of cellular metabolism in regulating cell proliferation and differentiation remains poorly understood. For example, most mammalian cells cannot proliferate without exogenous glutamine supplementation even though glutamine is a non-essential amino acid. Here we show that mouse embryonic stem

Microenvironmental pH-modified solid dispersions to enhance the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti-prostate cancer drug: preparation, characterization and evaluation in vivo.

Meiyan Yang et al.

International journal of pharmaceutics, 475(1-2), 97-109 (2014-08-31)

The aim of the present work was to design a pH-modified solid dispersion (pH(M)-SD) that can improve the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti-prostate cancer drug. To select the appropriate acidifiers, a solubility test

[The research progress of succinic acid fermentation strains].

Qing-Zhao Wang et al.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 23(4), 570-576 (2007-09-08)

The potential of succinic acid as an important chemical intermediates had been realized and fermentation is one of the best ways to make it possible in economical aspect. Fermentation organism is the key part of the fermentation method. The updated

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples

Zaky AS

J. Food Compos. Anal., 56(1-2), 25-33 (2017)

Mitochondrial metabolism and stress response of yeast: Applications in fermentation technologies.

Hiroshi Kitagaki et al.

Journal of bioscience and bioengineering, 117(4), 383-393 (2013-11-12)

Mitochondria are sites of oxidative respiration. During sake brewing, sake yeasts are exposed to long periods of hypoxia; the structure, role, and metabolism of mitochondria of sake yeasts have not been studied in detail. It was first elucidated that the

Simultaneous HPLC determination of organic acids, sugars and alcohols

Doyon G

Can. Inst. Food Sci Technol. J., 24(1-2), 87-94 (1991)

Unsuspected task for an old team: succinate, fumarate and other Krebs cycle acids in metabolic remodeling.

Paule Bénit et al.

Biochimica et biophysica acta, 1837(8), 1330-1337 (2014-04-05)

Seventy years from the formalization of the Krebs cycle as the central metabolic turntable sustaining the cell respiratory process, key functions of several of its intermediates, especially succinate and fumarate, have been recently uncovered. The presumably immutable organization of the

Comparative metabolomics analysis on invigorating blood circulation for herb pair Gui-Hong by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and pattern recognition approach.

Shujiao Li et al.

Journal of pharmaceutical and biomedical analysis, 107, 456-463 (2015-02-11)

The compatibility of Angelicae Sinensis Radix (Danggui, DG) and Flos Carthami (Honghua, HH), a famous herb pair Gui-Hong (GH), can produce synergistic and promoting blood effects. Although some physiological and pathological function parameters of the acute blood stasis have been

In vitro release of model compounds with different hydrophilicity from poly(ester-anhydride) microspheres.

Katarzyna Jaszcz

Acta poloniae pharmaceutica, 70(6), 1051-1063 (2014-01-05)

Poly(ester-anhydride) microspheres were prepared using emulsion solvent evaporation technique from two copolymers obtained by polycondensation of sebacic acid (SBA) and oligo(3-allyloxy-1,2-propylene succinate) terminated with carboxyl groups (OSAGE). The SBA content in copolymers was 90 or 70 w/w %, respectively. The

Food additives data book

Food additives data book, 56, 66-69 (2003)

Simultaneous Determination of Succinic Acid and Water-Soluble Vitamins by Ion-Pair High-Performance Liquid Chromatography

Leonov KA

Journal of Analytical Chemistry, 73(4), 358-363 (2018)

GC-MS analysis of organic acids in human urine in clinical settings: a study of derivatization and other analytical parameters.

Chrysoula Christou et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 964, 195-201 (2014-02-01)

In the current paper the analytical conditions for the determination of ten free organic acids by GC-MS are studied with the aim to establish a method for organic acid profiling in human urine to be used as a tool for

Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer.

Hoon Hur et al.

PloS one, 9(6), e98581-e98581 (2014-06-10)

The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous

Downstream processing of biotechnological produced succinic acid.

Ke-Ke Cheng et al.

Applied microbiology and biotechnology, 95(4), 841-850 (2012-06-19)

Succinic acid is a promising chemical which has a wide range of applications and can be biologically produced. The separation of succinic acid from fermentation broth makes more than 50 % of the total costs in their microbial production. This review

Comparative metabolomic-based metabolic mechanism hypothesis for microbial mixed cultures utilizing cane molasses wastewater for higher 2-phenylethanol production.

Xinrong Pan et al.

Journal of agricultural and food chemistry, 62(40), 9927-9935 (2014-09-10)

The mixed microbes coculture method in cane molasses wastewater (CMW) was adopted to produce 2-phenylethanol (2-PE). Comparative metabolomics combined with multivariate statistical analysis was performed to profile the differences of overall intracellular metabolites concentration for the mixed microbes cocultured under

Determination of lactic, acetic, succinic, and citric acids in table olives by HPLC/UV

Cunha SC, et al.

Journal of Liquid Chromatography and Related Technologies, 24(7), 1029-1038 (2001)

Functional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiency.

Patrick Forny et al.

Human mutation, 35(12), 1449-1458 (2014-08-16)

Methylmalonyl-CoA mutase (MUT) is an essential enzyme in propionate catabolism that requires adenosylcobalamin as a cofactor. Almost 250 inherited mutations in the MUT gene are known to cause the devastating disorder methylmalonic aciduria; however, the mechanism of dysfunction of these

Ercella succinigenes gen. nov., sp. nov., an anaerobic succinate-producing bacterium.

Antonie H van Gelder et al.

International journal of systematic and evolutionary microbiology, 64(Pt 7), 2449-2454 (2014-04-30)

A novel anaerobic succinate-producing bacterium, strain ZWB(T), was isolated from sludge collected from a biogas desulfurization bioreactor (Eerbeek, the Netherlands). Cells were non-spore-forming, motile, slightly curved rods (0.4-0.5 µm in diameter and 2-3 µm in length), and stained Gram-negative. The

Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity.

Yi Liu et al.

International journal of nanomedicine, 10, 2295-2311 (2015-04-08)

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with

Properties and extraction of pectin-enriched materials from sugar beet pulp by ultrasonic-assisted treatment combined with subcritical water.

Hai-ming Chen et al.

Food chemistry, 168, 302-310 (2014-08-31)

Pectin-enriched material (PEM) was extracted from sugar beet pulp using subcritical water combined with ultrasonic-assisted treatment. Optimisation of the reaction parameters for maximum extraction yield of PEM was carried out using response surface methodology. Optimum modification conditions were as follows:

Succinic acid

Pharmacopeia, US

United States Pharmacopeia/National Formulary, 39(2), 6012-6012 (2018)

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Arijeet K Gattu et al.

Endocrinology, 155(4), 1373-1385 (2014-01-25)

Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers, and metabolic homeostasis. Male PEDF KO

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.

Carla J Aguiar et al.

Cell communication and signaling : CCS, 12, 78-78 (2014-12-30)

Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in several tissues, including heart. Because some pathological conditions such as ischemia increase

Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential.

Hélène Pelicano et al.

Breast cancer research : BCR, 16(5), 434-434 (2014-09-12)

Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agents, therefore, further understanding of the biological properties of these cancer

Enhanced performance of a three-zone simulated moving bed chromatography for separation of succinic acid and lactic acid by simultaneous use of port-location rearrangement and partial-feeding.

Sungyong Mun

Journal of chromatography. A, 1350, 72-82 (2014-06-03)

The performance of a three-zone simulated moving bed (SMB) chromatographic process for separation of succinic acid and lactic acid has been improved to a certain extent in previous researches by applying either a partial-feeding (PF) or a port-location rearrangement (PR)

Improving pharmacy students' understanding and long-term retention of acid-base chemistry

Roche VF

American journal of pharmaceutical education, 71(6), 122-122 (2007)

Towards large scale fermentative production of succinic acid.

Mickel L A Jansen et al.

Current opinion in biotechnology, 30, 190-197 (2014-08-15)

Fermentative production of succinic acid (SA) from renewable carbohydrate feed-stocks can have the economic and sustainability potential to replace petroleum-based production in the future, not only for existing markets, but also new larger volume markets. To accomplish this, extensive efforts

Anti-thrombotic effect of a novel formula from Corni fructus with malic acid, succinic acid and citric acid.

Qi-Chun Zhang et al.

Phytotherapy research : PTR, 28(5), 722-727 (2013-08-06)

Our previous investigation had confirmed the inhibition of platelet aggregation of a novel Corni fructus-derived formula composed of malic acid, succinic acid and citric acid with a ratio of 3:2:2. The present study was to further evaluate the anti-thrombotic effect

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