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Showing 1-30 of 114 results for "s8761" within Papers
Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence.
Burkhard Simma et al.
Critical care medicine, 41(9), 2242-2243 (2013-08-28)
Joanne Marie M Del Rosario et al.
Frontiers in immunology, 11, 627-627 (2020-06-18)
Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a-B6, an alpaca-derived single
Stephen J Traub et al.
Annals of emergency medicine, 62(5), 511-520 (2013-06-19)
We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy. The design was a randomized, double blind, 2-center, placebo-controlled interventional trial. Inclusion criteria were patients undergoing
Daniel J Peart et al.
Journal of strength and conditioning research, 26(7), 1975-1983 (2012-04-17)
Sodium bicarbonate (NaHCO3) is a buffering agent that is suggested to improve performance by promoting the efflux of hydrogen ions from working cells and tissues. Research surrounding its efficacy as an ergogenic aid is conflicting, making it difficult to draw
Vincent Pavot et al.
Human vaccines & immunotherapeutics, 17(7), 2336-2348 (2021-01-12)
Adjuvants are central to the efficacy of subunit vaccines. Although several new adjuvants have been approved in human vaccines over the last decade, the panel of adjuvants in licensed human vaccines remains small. There is still a need for novel
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
Nicoline Dorothea Jakobsen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 178, 106282-106282 (2022-08-23)
Rat epidermal keratinocyte (REK) Organotypic culture (ROC) is an epidermis model that is robust and inexpensive to develop and maintain, and it has in previous studies been shown to have permeability characteristics close to those of human skin. Here, we
Oesophageal bezoar induced by black beans successfully removed by associating endoscopy and oral sodium bicarbonate.
Miao-Yan Chen et al.
Acta gastro-enterologica Belgica, 76(3), 347-347 (2013-11-23)
Chinwendu Nwadike et al.
Molecular and cellular biology, 38(10) (2018-03-07)
Autophagy maintains metabolism in response to starvation, but each nutrient is sensed distinctly. Amino acid deficiency suppresses mechanistic target of rapamycin complex 1 (MTORC1), while glucose deficiency promotes AMP-activated protein kinase (AMPK). The MTORC1 and AMPK signaling pathways converge onto
Lia H Campbell et al.
Cryobiology, 64(3), 240-244 (2012-03-01)
Dimethylsulfoxide, the most commonly employed cryoprotectant for cells, has well documented cytotoxic effects in patients. Among the compounds available that may provide protection to cells and tissues during preservation with less cytotoxicity is trehalose. Some animals, such as brine shrimp
Mayu Sugawara et al.
Biochemistry and biophysics reports, 27, 101101-101101 (2021-08-26)
Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial calpain-1 cleaves apoptosis-inducing factor (AIF), leading to apoptotic cell
Anna Ohradanova et al.
Bioorganic & medicinal chemistry letters, 22(3), 1314-1316 (2012-01-10)
An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side
Rashmi Aggarwal et al.
Indian journal of experimental biology, 50(11), 826-832 (2013-01-12)
The present study reports molecular characterization of small heat shock protein gene in Indian isolates of Chaetomium globosum, C. perlucidum, C. reflexum, C. cochlioides and C. cupreum. Six isolates of C. globosum and other species showed a band of 630bp
Sodium bicarbonate use in acute kidney injury.
Mark D Uniacke et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(3), 523-523 (2013-01-08)
Shuvasree SenGupta et al.
Frontiers in immunology, 12, 659996-659996 (2021-04-30)
Tumor associated neutrophils (TANs) are frequently detected in triple-negative breast cancer (TNBC). Recent studies also reveal the importance of neutrophils in promoting tumor progression and metastasis during breast cancer. However, the mechanisms regulating neutrophil trafficking to breast tumors are less
U Ozgul et al.
Anaesthesia and intensive care, 41(4), 501-504 (2013-07-03)
The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection. This prospective, randomised, double-blind study included 300 adult, American Society of Anesthesiologists physcial status I to II
Antonio Lacquaniti et al.
Radiology, 267(1), 86-93 (2013-01-09)
To evaluate the utility of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) in depicting an event of contrast material-induced nephropathy (CIN) in patients who received iodinated contrast media, gadoterate meglumine, or radiopharmaceutical technetium-99m ((99m)Tc) and to evaluate the protective effect
Mark D Parker et al.
Physiological reviews, 93(2), 803-959 (2013-04-17)
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review
Peter Burghout et al.
Bioorganic & medicinal chemistry, 19(1), 243-248 (2010-12-18)
The Gram-positive bacterium Streptococcus pneumoniae is a human respiratory tract pathogen that contributes significantly to global mortality and morbidity. It was recently shown that this bacterial pathogen depends on a conserved β-carbonic anhydrase (CA, EC 4.2.1.1) for in vitro growth
Best evidence topic report. Treatment of jellyfish stings in UK coastal waters: vinegar or sodium bicarbonate?
Heather Prestwich et al.
Emergency medicine journal : EMJ, 24(9), 664-664 (2007-08-23)
Antoine Kimmoun et al.
Anesthesiology, 120(4), 926-934 (2013-11-23)
Lactic acidosis is associated with cardiovascular failure. Buffering with sodium bicarbonate is proposed in severe lactic acidosis. Bicarbonate induces carbon dioxide generation and hypocalcemia, both cardiovascular depressant factors. The authors thus investigated the cardiovascular and metabolic effects of an adapted
Alessandra Cincinelli et al.
Bioorganic & medicinal chemistry, 19(6), 1847-1851 (2011-03-08)
A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that
Ruth M Hobson et al.
International journal of sports physiology and performance, 9(1), 139-144 (2013-04-13)
The ability to buffer H+ could be vital to exercise performance, as high concentrations of H+ contribute to the development of fatigue. The authors examined the effect of sodium bicarbonate (SB) supplementation on 2000-m rowing-ergometer performance. Twenty male rowers (age
Sally M Bradberry et al.
Toxicological reviews, 24(3), 195-204 (2006-01-05)
Experimental studies suggest that both alkalinisation and sodium loading are effective in reducing cardiotoxicity independently. Species and experimental differences may explain why sodium bicarbonate appears to work by sodium loading in some studies and by a pH change in others.
Vivian Barbosa Pinheiro et al.
Urology, 82(1), 33-37 (2013-04-23)
To evaluate the effects of oral sodium bicarbonate (NaBic) supplementation upon urinary citrate excretion in calcium stone formers (CSFs). Sixteen adult calcium stone formers with hypocitraturia were enrolled in a randomized, double-blind, crossover protocol using 60 mEq/day of NaBic during
Chang Gyun Park et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 230, 108704-108704 (2020-01-14)
The purpose of the present study was to examine the antioxidant and oxidative stress changes in zebrafish liver (ZFL) cells in the presence of mono-(2-ethylhexyl) phthalate (MEHP). When reactive oxygen species (ROS) and antioxidant levels were measured by immunoassay, significant
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Nida Siddiqui et al.
Nature communications, 10(1), 2693-2693 (2019-06-21)
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of
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