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Showing 31-60 of 79 results for "SML0282" within Papers
Diana M Mitchell et al.
PLoS genetics, 11(8), e1005483-e1005483 (2015-08-22)
The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebrafish embryos were treated with RA
Katherine D LaClair et al.
Molecular neurodegeneration, 8, 18-18 (2013-06-15)
Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein
M Maekawa et al.
Translational psychiatry, 7(9), e1229-e1229 (2017-09-06)
The risk of schizophrenia is increased in offspring whose mothers experience malnutrition during pregnancy. Polyunsaturated fatty acids (PUFAs) are dietary components that are crucial for the structural and functional integrity of neural cells, and PUFA deficiency has been shown to
Helmut Pein et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(10), 4566-4577 (2017-07-09)
Protein kinases, including the serine/threonine kinase Akt, mediate manifold bioactivities of vitamin A, although the mechanisms behind the sustained kinase activation are diffuse. To investigate the role of cellular lipids as targetable factors in Akt signaling, we combined mass spectrometry-based
Hua Yang et al.
Anti-cancer agents in medicinal chemistry, 18(3), 401-411 (2017-03-31)
Retinoids are important agents for the treatment of cutaneous T-cell lymphomas (CTCL). But side effects and drug resistance caused by activation of RAR/RXR limited their clinical application. Therefore, it is urgent to develop new agents to fight against CTCL. ECPIRM
Shun-Ming Ting et al.
Stroke, 51(3), 958-966 (2020-01-10)
Background and Purpose- Phagocytic cells, such as microglia and blood-derived macrophages, are a key biological modality responsible for phagocytosis-mediated clearance of damaged, dead, or displaced cells that are compromised during senescence or pathological processes, including after stroke. This process of
Sadie L Hebert et al.
Experimental cell research, 361(1), 101-111 (2017-10-12)
One major difference between limb and extraocular muscles (EOM) is the presence of an enriched population of Pitx2-positive myogenic precursor cells in EOM compared to limb muscle. We hypothesize that retinoic acid regulates Pitx2 expression in EOM myogenic precursor cells
Zita Hubler et al.
Nature, 560(7718), 372-376 (2018-07-27)
Regeneration of myelin is mediated by oligodendrocyte progenitor cells-an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS underlies a number of neurological diseases
Yasuhiro Ishihara et al.
The Journal of steroid biochemistry and molecular biology, 193, 105421-105421 (2019-07-03)
Increasing evidence has shown that one of the major neurosteroids, estradiol, has potent neuroprotective actions. We have reported that estradiol synthesis was enhanced when retinoic acid was added into rat hippocampal slice culture. In this study, we investigated the effects
The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor
Li Y, et al.
Breast Cancer Research and Treatment, 128(3), 667-677 (2011)
Iliya Lefterov et al.
Neurobiology of disease, 82, 132-140 (2015-06-15)
We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improved clearance of soluble Aβ
Alexandra Lasch et al.
Archives of toxicology, 94(4), 1303-1320 (2020-03-04)
Activation of nuclear receptors (NR), for example the retinoid-X-receptors (RXR) or the liver-X-receptors (LXR), plays a crucial role as the molecular initiating event in the adverse outcome pathway for liver steatosis. The downstream biological consequences of NR interactions are still
Lu Xu et al.
PloS one, 10(4), e0122744-e0122744 (2015-04-07)
Matrix metalloproteinase-9 (MMP-9) over-expression disrupts the blood-brain barrier (BBB) in the ischemic brain. The retinoid X receptor agonist bexarotene suppresses MMP-9 expression in endothelial cells and displays neuroprotective effects. Therefore, we hypothesized that bexarotene may have a beneficial effect on
Wai-Ping Lee et al.
Biochemical and biophysical research communications, 464(1), 195-200 (2015-06-28)
The present study investigated human retinoid X receptor alpha (hRXRα) as a substrate for modification with small ubiquitin like modifier (SUMO) and how members of the protein inhibitor of activated STAT (PIAS) family may impact upon this process. In agreement
Daisuke Morichika et al.
Respiratory research, 20(1), 2-2 (2019-01-05)
Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors
Yu Li et al.
International journal of molecular medicine, 44(5), 1963-1970 (2019-09-24)
Rheumatoid arthritis (RA) is a debilitating joint disease characterized by chronic inflammation, pathologic alteration of fibroblast‑like synoviocytes (FLS), destruction of cartilage and bone, and the formation of an invasive pannus. RA‑FLS exhibit increased proliferation and resistance to apoptosis. The retinoid
Chu-Fang Chou et al.
Journal of dermatological science, 90(3), 343-356 (2018-03-31)
Bexarotene (Targretin®) is currently the only FDA approved retinoid X receptor (RXR) -selective agonist for the treatment of cutaneous T-cell lymphomas (CTCLs). The main side effects of bexarotene are hypothyroidism and elevation of serum triglycerides (TGs). The novel RXR ligand
Oleg Kruglov et al.
Blood advances, 4(19), 4788-4797 (2020-10-06)
The therapy of advanced mycosis fungoides (MF) presents a therapeutic challenge, and the search for new therapeutic targets is ongoing. Poly(ADP-ribose) polymerase 1 was shown to be upregulated in patients with advanced MF and could be druggable by a new
Wei Wang et al.
Journal of natural medicines, 73(1), 154-162 (2018-11-01)
Neuronal cell death induced by amyloid-β (Aβ) oligomers is implicated in neuronal degeneration and is a leading cause of Alzheimer's disease (AD). Therefore, to identify effective therapeutic agents for AD, we investigated the neuroprotective effects of two naturally occurring retinoid
Kenneth M McCullough et al.
Translational psychiatry, 8(1), 164-164 (2018-08-24)
Behavioral and molecular characterization of cell-type-specific populations governing fear learning and behavior is a promising avenue for the rational identification of potential therapeutics for fear-related disorders. Examining cell-type-specific changes in neuronal translation following fear learning allows for targeted pharmacological intervention
Pratim Chowdhury et al.
Journal of cell science, 131(24) (2018-12-07)
Loss of the gene von Hippel-Lindau (VHL) is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We developed an image-based high-throughput screening (HTS) assay using a dual-labeling image analysis strategy
Kwame Osei-Sarfo et al.
PloS one, 14(4), e0215234-e0215234 (2019-04-13)
To gain a greater understanding of oral squamous cell carcinoma (OSCC) we investigated the actions of all-trans-retinoic acid (RA; a retinoid), bexarotene (a pan-RXR agonist), and forkhead box (FOX) transcription factors in human OSCC-derived cell lines. RA and bexarotene have
Fang Cheng et al.
Experimental cell research, 360(2), 171-179 (2017-09-13)
Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes. Heparan sulfate penetrates the membrane and is transported to the nucleus. This process is dependent on copper and on expression and processing of the amyloid
Yongjie Wang et al.
Drug development and industrial pharmacy, 43(1), 132-141 (2016-09-03)
The objective of this study was to develop and evaluate the morphology, biodistribution and antitumor activity of bexarotene nanocrystals delivery system. The morphology was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscope and bexarotene nanocrystals
Wenyu Dai et al.
International journal of molecular medicine, 47(2), 607-620 (2021-01-09)
The mechanisms of inflammation in bone and joint tissue are complex and involve long non‑coding RNAs (lncRNAs), which play an important role in this process. The aim of the present study was to screen out differentially expressed genes in human
Kelly E Sullivan et al.
Oncotarget, 8(14), 22325-22343 (2017-04-21)
Tissue transglutaminase (tTG), a dual-function enzyme with GTP-binding and acyltransferase activities, has been implicated in the survival and chemotherapy resistance of aggressive cancer cells and cancer stem cells, including glioma stem cells (GSCs). Using a model system comprising two distinct
Ken-Ichi Nakashima et al.
Biochimica et biophysica acta, 1840(10), 3034-3041 (2014-06-28)
Brazilian green propolis (BGP), a resinous substance produced from Baccharis dracunculifolia by Africanized honey bees (Apis mellifera), is used as a folk medicine. Our present study explores the retinoid X receptor (RXR) agonistic activity of BGP and the identification of
Clarissa S Santoso et al.
Nucleic acids research, 48(21), 12055-12073 (2020-11-13)
Proper cytokine gene expression is essential in development, homeostasis and immune responses. Studies on the transcriptional control of cytokine genes have mostly focused on highly researched transcription factors (TFs) and cytokines, resulting in an incomplete portrait of cytokine gene regulation.
Jianjun Zhong et al.
Brain, behavior, and immunity, 65, 183-194 (2017-05-10)
Bexarotene treatments exert neuroprotective effects on mice following traumatic brain injury (TBI). The present study aims to investigate the potential roles of the long noncoding RNA Neat1 in the neuroprotective effects of bexarotene. Adult male C57BL/6J mice (n=80) and newborn
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma
Wells CE, et al.
PLoS ONE, 8(7), e68915-e68915 (2013)
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