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- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017-07-09)
Helmut Pein, Solveigh C Koeberle, Maria Voelkel, Freya Schneider, Antonietta Rossi, Maria Thürmer, Konstantin Loeser, Lidia Sautebin, Helen Morrison, Oliver Werz, Andreas Koeberle
PMID28687611
ABSTRACT
Protein kinases, including the serine/threonine kinase Akt, mediate manifold bioactivities of vitamin A, although the mechanisms behind the sustained kinase activation are diffuse. To investigate the role of cellular lipids as targetable factors in Akt signaling, we combined mass spectrometry-based lipidomics with immunologic detection of Akt (Ser473) phosphorylation. A screening campaign revealed retinol (vitamin A alcohol) and all-