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Showing 61-90 of 137 results for "T3824" within Papers
Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1).
R A Spritz et al.
Human mutation, 10(2), 171-174 (1997-01-01)
Marion Verdoni et al.
Bioorganic & medicinal chemistry, 24(22), 5685-5692 (2016-10-26)
To discover new molecules with an inhibitory activity of melanogenesis a hundred of scorpions, snakes, spiders and amphibians venoms were screened for their capacity to inhibit mushroom tyrosinase using 3,4-l-dihydroxyphenylalanine (l-DOPA) as substrate. The Argiope lobata spider venom proved to
Shilpi Goenka et al.
Biomedicines, 8(10) (2020-10-18)
CMT-308 is a nonantimicrobial chemically-modified tetracycline (CMT), which we have previously shown exhibits antifungal activity and pleiotropic anti-inflammatory activities, including inhibition of the enzymatic activity of matrix metalloproteinases (MMPs). Based on its chemical structure, we hypothesized that CMT-308 could inhibit
A T S Jorge et al.
International journal of cosmetic science, 34(5), 435-440 (2012-06-29)
Several treatments for skin whitening are available today, but few of them are completely adequate, especially owing to the carcinogenic potential attributed to classical drugs like hydroquinone, arbutin and kojic acid. To provide an alternative and safer technology for whitening
Yang Yao et al.
International journal of molecular sciences, 12(10), 7048-7058 (2011-11-11)
Phenolic acids have been identified in a variety of legumes including lima bean, broad bean, common bean, pea, jack bean, goa bean, adzuki bean, hyacinth bean, chicking vetch, garbanzo bean, dral, cow bean, rice bean, mung bean and soybean. The
Dae Hyun Shin et al.
Pharmaceutical biology, 51(11), 1467-1476 (2013-10-11)
Sophora flavescens Ait. (Leguminosae) has been proposed as a new whitening agent for cosmetics, because it has a strong ability to inhibit tyrosinase, a key enzyme in the formation of melanin. We conducted a study to determine whether ethanol extract
Renwei Jing et al.
Experimental eye research, 119, 35-43 (2013-12-24)
The eye has pigmented cells of two different embryonic origins and therefore it is a good model for studying melanosome biogenesis and melanin production/deposition. Pale ear mice bear a mutation in the Hermansky-Pudlak syndrome type 1 (HPS-1) gene and exhibit
Hak-Ju Kim et al.
Journal of cosmetic science, 64(2), 89-98 (2013-04-13)
Effective and safe antimelanogenic agents derived from natural products get interest continuously for both medical and cosmetic purposes. Melanin synthesis is regulated by melanogenic enzymes such as tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) in mammals. Gastrodia
Wenlin Xie et al.
Chemical biology & drug design, 86(5), 1087-1092 (2015-04-29)
A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction of 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole, and their inhibitory effects on mushroom tyrosinase were evaluated. The results indicated that most of the synthesized compounds exhibited significant inhibitory activity. Specifically, 5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole
Jéssica P S Silveira et al.
BMC complementary and alternative medicine, 13, 49-49 (2013-03-01)
Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase
Dorota Wrześniok et al.
Acta poloniae pharmaceutica, 70(5), 803-808 (2013-10-24)
It is known that aminoglycoside antibiotics bind well to melanin biopolymer, but the relation between their affinity to melanin and ototoxicity is not well established. The aim of this work was to examine the impact of netilmicin on melanogenesis in
V Khan et al.
Ontogenez, 43(6), 436-446 (2013-02-14)
Apoptosis and differentiation in presumptive neural retina (PNR) and presumptive retinal pigmented epithelium (PRPE) wert investigated during early retina development of toad, Bufo raddei Strauch. TUNEL staining was used to evaluate apoptotic cells and the immunohistochemistry was used to assess
Daniela S Gerhard et al.
Genome research, 14(10B), 2121-2127 (2004-10-19)
The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random
C H Tsai et al.
Human mutation, 14(6), 542-542 (1999-11-26)
Type I oculocutaneous albinism (OCA1) is an autosomal recessive disorder, which is caused by the reduction or the absence of tyrosinase activity in melanocytes of the skin, hair and eyes. Although tyrosinase mutations of OCA1 have been extensively analyzed in
Ga Young Lee et al.
Archives of pharmacal research, 41(5), 490-496 (2018-05-04)
Ten compounds (1-10) isolated from the seeds of Cassia tora were evaluated for tyrosinase inhibition. Compounds 3, 4, and 7 inhibited tyrosinase enzymatic activity in a dose-dependent manner, with IC50 values of 3.0 ± 0.8, 7.0 ± 0.4, and 9.2 ± 3.4 μM, respectively. Kinetic analyses revealed
Flipping the phenotypic switch on a novel antimelanoma differentiation strategy.
Willie Wilson et al.
Pigment cell & melanoma research, 26(6), 791-793 (2013-10-25)
Potato phenolases. Purification and properties.
S S Patil et al.
The Journal of biological chemistry, 240(10), 3938-3943 (1965-10-01)
Sven Opitz et al.
Human mutation, 23(6), 630-631 (2004-05-18)
Oculocutaneous albinism (OCA) in man may be caused by mutations within the tyrosinase gene (TYR) resulting in OCA1. Analysing patients with recessively inherited albinism we found DNA variations in 82 unrelated individuals. 53 out of 78 mutations and polymorphisms revealed
L B Giebel et al.
American journal of human genetics, 48(6), 1159-1167 (1991-06-01)
We have identified three different tyrosinase gene mutant alleles in four unrelated patients with type IB ("yellow") oculocutaneous albinism (OCA) and thus have demonstrated that type IB OCA is allelic to type IA (tyrosinase negative) OCA. In an inbred Amish
Shinya Kato et al.
Journal of nanoscience and nanotechnology, 13(1), 52-59 (2013-05-08)
We investigated the anti-melanogenetic efficacy of hydrogen-occluding silica microcluster (H2-Silica), which is a silsesquioxane-based compound with hydrogen interstitially embedded in a matrix of caged silica, against melanogenesis in HMV-II human melanoma cells and L-DOPA-tyrosinase reaction [EC1.14.18.1]. HMV-II cells were subjected
R A Spritz et al.
American journal of human genetics, 48(2), 318-324 (1991-02-01)
We have identified a tyrosinase gene mutation in an American black with classic, tyrosinase-negative oculocutaneous albinism. This mutation results in an amino acid substitution (Cys----Arg) at codon 89 of the tyrosinase polypeptide. The proband is homozygous for the substitution, suggesting
Eric W C Chan et al.
Pharmacognosy research, 3(3), 178-184 (2011-10-25)
Chlorogenic acid (CGA) or 5-caffeoylquinic acid, was found to be the dominant phenolic compound in leaves of Etlingera elatior (Zingiberaceae). The CGA content of E. elatior leaves was significantly higher than flowers of Lonicera japonica (honeysuckle), the commercial source. In
Su-Jin Lim et al.
International journal of molecular sciences, 23(23) (2022-12-12)
Excess melanin in skin is known to be the main cause of hyper-pigmentary skin diseases such as freckles and lentigo. This study aimed to evaluate the depigmenting efficacy of an extract from the marine microorganism strain, Streptomyces sp. SNA077. To
Yan Mu et al.
Journal of cosmetic science, 64(2), 99-110 (2013-04-13)
Tyrosinase inhibitors from natural plants are currently attracting great interest. In this study, vanillic acid (VA) from red globe amaranth flower was identified as an effective tyrosinase inhibitor. The 50% inhibitory concentration values of VA were 0.53 and 0.63 mg/ml
Shan-Liang Xu et al.
Fish & shellfish immunology, 35(5), 1577-1584 (2013-09-17)
We explored the pathogenic mechanism of Vibrio alginolyticus in the stone crab Charybdis japonica by studying the hemolymph of C. japonica artificially infected by V. alginolyticus. To this end, Wright-Geimsa staining and electron microscopy were used, and phenoloxidase (PO) activity
G S Cruz et al.
Journal of economic entomology, 107(1), 144-153 (2014-03-29)
The combination of essential oils and Bacillus thuringiensis Berliner may represent an interesting control strategy. Thus, the study tested the following hypothesis: the combination of long pepper oil (Piper hispidinervum L.) and clove (Syzygium aromaticum L.) oils in two concentrations
Jang Hoon Kim et al.
Marine drugs, 17(6) (2019-06-19)
Tyrosinase inhibitors improve skin whitening by inhibiting the formation of melanin precursors in the skin. The inhibitory activity of seven phlorotannins (1-7), triphlorethol A (1), eckol (2), 2-phloroeckol (3), phlorofucofuroeckol A (4), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (5), 6,8'-bieckol (6), and 8,8'-bieckol (7), from
Lih-Geeng Chen et al.
Biological & pharmaceutical bulletin, 32(8), 1447-1452 (2009-08-05)
Nowadays herbal medicines of skin-whitening cosmetics are popular with women. We attempted to find the whitening activity compounds present in many herbal medicines used for this purpose and discuss their mechanisms in melanin biosynthesis. The 70% acetone extracts of 10
G S Murzagulov et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 49(1), 24-29 (2013-05-15)
The work deals with effect of density of population on functional activity of components pf protective system of adult individuals and nymphs of the marble cockroach. The resistance of individuals has been noted to decrease both at individual maintenance and
Pedro Fong et al.
Natural product communications, 9(2), 189-194 (2014-04-03)
Although many herbal medicines are effective in the treatment of hyperpigmentation, the potency of different constituents remains unknown. In this work, more than 20,000 herbal ingredients from 453 herbs were docked into the crystal structures of adenylyl cyclase and a
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