T3824

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Showing 61-90 of 137 results for "T3824" within Papers

Mutations of the human tyrosinase gene associated with tyrosinase related oculocutaneous albinism (OCA1). Mutations in brief no. 204. Online.

W S Oetting et al.

Human mutation, 12(6), 433-434 (2000-02-12)

Mutations in the human tyrosinase gene produce tyrosinase-related oculocutaneous albinism (OCA1, MIM #203100). Tyrosinase is a copper containing enzyme and is responsible for catalyzing the rate limiting step in melanin biosynthesis, the hydroxylation of tyrosine to dopaquinone. We report 13

Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells.

Chung-Oui Hong et al.

Bioscience, biotechnology, and biochemistry, 77(1), 58-64 (2013-01-08)

Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae) and to evaluate their antimelanogenic activities on B16F10 melanoma cells. Organic solvent

ARP101 inhibits α-MSH-stimulated melanogenesis by regulation of autophagy in melanocytes.

Eun Sung Kim et al.

FEBS letters, 587(24), 3955-3960 (2013-11-06)

Autophagy is a cooperative process between autophagosomes and lysosomes that degrades cellular organelles. Although autophagy regulates the turnover of cellular components, its role in melanogenesis is not clearly established. Previously, we reported that ARP101 induces autophagy in various cancer cells.

Promotion and computation of inhibitory effect on tyrosinase activity of herbal cream by incorporating indigenous medicinal plants.

Ram Kumar Sahu et al.

Pakistan journal of biological sciences : PJBS, 17(1), 146-150 (2014-05-03)

Herbal cream imparts a chief role in regulating melanin production of skin. The phytoconstituents present in herbal cream impact biological functions of skin and contribute nutrients required for the healthy skin. In the present study, it was envisaged to prepare

Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.

W S Oetting et al.

Human mutation, 13(2), 99-115 (1999-03-27)

Albinism, caused by a deficiency of melanin pigment in the skin, hair, and eye (oculocutaneous albinism [OCA]), or primarily in the eye (ocular albinism [OA]), results from mutations in genes involved in the biosynthesis of melanin pigment. The lack of

Antioxidant and defense genetic expressions in corn at early-developmental stage are differentially modulated by copper form exposure (nano, bulk, ionic): Nutrient and physiological effects.

Carolina Valdes et al.

Ecotoxicology and environmental safety, 206, 111197-111197 (2020-09-04)

In the present study, Zea mays seedlings grown under nano Cu(OH)2 (nCu), bulk Cu(OH)2 (bCu), and ionic CuSO4 (iCu) compound exposure were harvested after six days. The nutritional profile was determined to be significantly disrupted in the roots by 1000 ppm

Tyrosinase activity of peroxidase of red beet root vacuoles and plastids.

E V Pradedova et al.

Doklady. Biochemistry and biophysics, 448, 9-12 (2013-03-13)

Zhenxing Wang et al.

Foods (Basel, Switzerland), 10(2) (2021-02-07)

This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect of P. frutescens leaf, which is a traditional medicine-food homology plant. P. frutescens methanol crude extract and its fractions (petroleum ether, chloroform, ethyl acetate

Multiple biological effects of secondary metabolites of Ziziphus jujuba: isolation and mechanistic insights through in vitro and in silico studies.

Didem Şöhretoğlu et al.

European food research and technology = Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. A, 248(4), 1059-1067 (2022-01-18)

In this study, we tested tyrosinase and α-glucosidase effects of different extracts of Ziziphus jujuba fruits. The n-BuOH subextract inhibited both tyrosinase and α-glucosidase (IC50 = 18.82 ± 1.13 and 25.03 ± 0.77 µg/mL, respectively) better than the positive controls kojic acid and acarbose (IC50 = 58.26 ± 0.25 and 46.10 ± 2.3 µg/mL

Functional analysis of the cDNA encoding human tyrosinase precursor.

A Takeda et al.

Biochemical and biophysical research communications, 162(3), 984-990 (1989-08-15)

The DNA segment harboring the promoter region and the exon 1 of the human tyrosinase gene has been cloned and characterized. Sequence analysis reveals the amino-terminal half of tyrosinase molecule including a signal peptide, of which six amino acid residues

Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens.

Jang Hoon Kim et al.

Journal of enzyme inhibition and medicinal chemistry, 33(1), 1048-1054 (2018-06-07)

Tyrosinase is known for an enzyme that plays a key role in producing the initial precursor of melanin biosynthesis. Inhibition of the catalytic reaction of this enzyme led to some advantage such as skin-whitening and anti-insect agents. To find a

Evaluation of in vitro inhibitory effects of some natural compounds on tyrosinase activity and molecular docking study: Antimelanogenesis potential.

Parham Taslimi

Journal of biochemical and molecular toxicology, 34(11), e22566-e22566 (2020-07-03)

Tyrosinase enzyme is a functional oxidase that is extensively divided in nature. It is the main enzyme in melanin synthesis and is also involved in designating the color of mammalian hair and skin. Additionally, it is accountable for the unfavorable

Mutation analysis of the tyrosinase gene in oculocutaneous albinism.

O Camand et al.

Human mutation, 17(4), 352-352 (2001-04-11)

Type I oculocutaneous albinism (OCA) is an autosomal recessive disorder caused by the reduction or the absence of tyrosinase (TYR) activity in melanocytes of the skin, hair and eyes. Here we report an analysis of 45 patients with OCA. We

Topobiology of human pigmentation: P-cadherin selectively stimulates hair follicle melanogenesis.

Liat Samuelov et al.

The Journal of investigative dermatology, 133(6), 1591-1600 (2013-01-22)

P-cadherin serves as a major topobiological cue in mammalian epithelium. In human hair follicles (HFs), it is prominently expressed in the inner hair matrix that harbors the HF pigmentary unit. However, the role of P-cadherin in normal human pigmentation remains

Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme.

Malte Rolff et al.

Chemical Society reviews, 40(7), 4077-4098 (2011-03-19)

The critical review describes the known dicopper systems mediating the aromatic hydroxylation of monophenolic substrates. Such systems are of interest as structural and functional models of the type 3 copper enzyme tyrosinase, which catalyzes the ortho-hydroxylation of tyrosine to DOPA

Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions.

R K Tripathi et al.

American journal of medical genetics, 43(5), 865-871 (1992-07-15)

Type I (tyrosinase-deficient) oculocutaneous albinism (OCA) results from mutations of the gene encoding tyrosinase, the enzyme that catalyzes the first 2 steps of melanin pigment biosynthesis. In type IA (tyrosinase-negative) OCA tyrosinase enzymatic activity is completely absent, and in type

Melanogenesis of methyl myristate loaded niosomes in B16F10 melanoma cells.

Aranya Manosroi et al.

Journal of biomedical nanotechnology, 9(4), 626-638 (2013-04-30)

The objective of this study was to compare the charge effect of methyl myristate loaded in neutral (Brij 72/cholesterol at 7:3), cationic (Brij 72/cholesterol/dimethyl dioctadecyl ammonium bromide at 7:3:0.65) and anionic niosomes (Brij 72/cholesterol/dicetyl phosphate at 7:3:0.65) for physicochemical characteristics

Acanthoic acid inhibits melanogenesis through tyrosinase downregulation and melanogenic gene expression in B16 melanoma cells.

Weon-Jong Yoon et al.

Natural product communications, 8(10), 1359-1362 (2013-12-21)

The aim of this study was to investigate the in vitro inhibitory effects of acanthoic acid (ACAN), isolated from Acanthopanax koreanum, on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 in B16 melanoma cells. We

Effects of the dietary administration of sodium alginate on the immune responses and disease resistance of Taiwan abalone, Haliotis diversicolor supertexta.

Winton Cheng et al.

Fish & shellfish immunology, 34(3), 902-908 (2013-01-09)

Sodium alginate extracted from brown algae was reported to enhance the immune response and resistance of fish and shrimp. In this study, survival rates of the abalone, Haliotis diversicolor supertexta, against Vibrio parahaemolyticus, and its non-specific immune parameters such as

Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment.

L B Giebel et al.

Genomics, 9(3), 435-445 (1991-03-01)

We have isolated and sequenced the gene encoding human tyrosinase, the key enzyme in pigment biosynthesis. The human tyrosinase gene contains five exons and spans more than 50 kb of DNA on chromosome segment 11q14----q21. We have also isolated a

Whitening Activity of Constituents Isolated from the Trichosanthes Pulp.

Rongchao Zhang et al.

Evidence-based complementary and alternative medicine : eCAM, 2020, 2582579-2582579 (2020-08-11)

Whitening cosmetics market has a bright future, and pure natural whitening products of traditional Chinese medicine have always been a research hotspot. In this research, the whitening active ingredient of Chinese medicine Trichosanthes pulp was isolated and purified for the

Myriocin, a serine palmitoyltransferase inhibitor, increases melanin synthesis in Mel-Ab cells and a skin equivalent model.

Hailan Li et al.

Die Pharmazie, 69(3), 187-191 (2014-04-11)

The purpose of this study was to investigate effects of myriocin, an inhibitor of serine palmitoyltransferase, on melanogenesis. It was found that myriocin increased melanin synthesis in a concentration-dependent manner. Moreover, myriocin up-regulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression

Quinoxaline-, dopamine-, and amino acid-derived metabolites from the edible insect Protaetia brevitarsis seulensis.

JungIn Lee et al.

Archives of pharmacal research, 40(9), 1064-1070 (2017-08-07)

Edible insects have been reported to produce metabolites showing various pharmacological activities, recently emerging as rich sources of health functional food. In particular, the larvae of Protaetia brevitarsis seulensis (Kolbe) have been used as traditional Korean medicines for treating diverse

Oxidative polymerization process of hydroxytyrosol catalysed by polyphenol oxidases or peroxidase: Characterization, kinetics and thermodynamics.

Pujun Xie et al.

Food chemistry, 337, 127996-127996 (2020-09-13)

Hydroxytyrosol oligomer prepared by bioenzyme shows stronger health-promoting properties than its monomer. However, the polymerization process carried out by laccase, tyrosinase or horseradish peroxidase is still lacking in term of product characterization, kinetics and thermodynamics. To achieve these aspects, ATR-FT-IR

Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons.

Benjamin D Liba et al.

Biofabrication, 5(1), 015008-015008 (2013-01-11)

Exciting opportunities in bioelectronics will be facilitated by materials that can bridge the chemical logic of biology and the digital logic of electronics. Here we report the fabrication of a dual functional hydrogel film that can harvest electrons from its

Natural Molybdenite- and Tyrosinase-Based Amperometric Catechol Biosensor Using Acridine Orange as a Glue, Anchor, and Stabilizer for the Adsorbed Tyrosinase.

Yan Zhang et al.

ACS omega, 6(21), 13719-13727 (2021-06-08)

To develop a natural mineral-based electrochemical enzyme biosensor, natural molybdenite (MLN), tyrosinase (TYR), and acridine orange (AO) were coadsorbed onto a glassy carbon electrode (GCE). The developed TYR/AO/MLN-GCE-based amperometric TYR biosensor exhibited excellent performance for highly sensitive determination of catechol

A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.

C D Chintamaneni et al.

Proceedings of the National Academy of Sciences of the United States of America, 88(12), 5272-5276 (1991-06-25)

We have determined a molecular defect to be the likely basis for inactivity of the tyrosinase (EC 1.14.18.1) from a patient with tyrosinase-negative oculocutaneous albinism. A single base (thymine) was inserted in exon 5 of the tyrosinase gene following codon

Immunity for nothing and the eggs for free: Apparent lack of both physiological trade-offs and terminal reproductive investment in female crickets (Gryllus texensis).

Atsushi Miyashita et al.

PloS one, 14(5), e0209957-e0209957 (2019-05-16)

Should females alter their reproductive strategy when attacked by pathogens? Two hypotheses provide opposite predictions. Terminal reproductive investment theory predicts that reproduction should increase when the risk of death increases. However, physiological trade-offs between reproduction and immune function might be

Molecular basis of type I (tyrosinase-related) oculocutaneous albinism: mutations and polymorphisms of the human tyrosinase gene.

W S Oetting et al.

Human mutation, 2(1), 1-6 (1993-01-01)

Type I (tyrosinase related) oculocutaneous albinism (OCA) results from mutations of the tyrosinase gene on chromosome 11q that lead to reduced or absent melanin pigment synthesis. The phenotype of Type I OCA is broad, ranging from a total lack to

Mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in Israel.

R Gershoni-Baruch et al.

American journal of human genetics, 54(4), 586-594 (1994-04-01)

We have analyzed the tyrosinase (TYR) gene in 38 unrelated patients with oculocutaneous albinism (OCA), derived from several different ethnic groups of the diverse population of Israel. We detected TYR gene mutations in 23 of the 34 patients with apparent

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