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Showing 1-30 of 148 results for "U6753" within Papers
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells
Leal AS, et al.
Bioorganic & Medicinal Chemistry, 20(19), 5774-5786 (2012)
Long Cui et al.
Bioorganic & medicinal chemistry, 16(24), 10356-10362 (2008-11-15)
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds
Soon Huat Tiong et al.
Fitoterapia, 102, 182-188 (2015-02-11)
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and
Lawrence Onyango A Manguro et al.
Journal of Asian natural products research, 14(11), 987-1001 (2012-10-27)
Phytochemical analysis of aqueous MeOH extract of Maesa lanceolata stem wood has led to the isolation of four new triterpene saponins characterized as 16α,21β-diacetoxy-22α-angeloyl-28-hydroxyolean-12-ene 3-O-[α-rhamnopyranosyl-(1″″ → 6‴)-β-glucopyranosyl-(1‴ → 3')][β-glucopyranosyl-(1″ → 2')]-β-glucuronopyranoside (1), 16α-acetoxy-21β-hydroxy-22α-angeloyl-13β,28-oxydoolean-28α-ol 3-O-[α-rhamnopyranosyl-(1″″ → 6‴)-β-glucopyranosyl-(1‴ → 4')][β-glucopyranosyl-(1″ → 2')]-α-arabinopyranoside (2), 16α-acetoxy-21β,22α-diangeloyl-13β,28-epoxyoleanane 3-O-[α-rhamnopyranosyl-(1″″ → 6‴)-β-glucopyranosyl-(1‴ → 4')][β-glucopyranosyl-(1″ → 2')]-β-xylopyranoside (3), and 16α,22α-diacetoxy-13β,28-oxydoolean-28α-ol 3-O-[β-glucopyranosyl-(1″ → 2')][β-glucopyranosyl-(1‴ → 3')]-β-glucuronopyranoside (4), together with the known
Pornpattra Maphanao et al.
Biochimica et biophysica acta. General subjects, 1864(12), 129708-129708 (2020-08-19)
Ursolic acid (UA) is a natural triterpenoid which possesses anti-cancer activity. However, little is known regarding the activity and molecular mechanism of UA in cholangiocarcinoma (CCA). Thus, we investigated the effects of UA on growth inhibition and apoptosis induction through
W C Lin et al.
Poultry science, 99(7), 3606-3616 (2020-07-04)
This study investigates the effects of Laetiporus sulphureus-fermented wheat bran (LS) as a feed supplementation on the immunomodulative properties in broiler chickens. Crude phenolic compounds, crude polysaccharides, crude triterpenoids, and ergosterol were determined in LS water extracts. In animal experiments
Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats.
Shih YH, et al.
Neuroscience Letters, 363(2), 136-140 (2004)
Yasutaka Ikeda et al.
Molecular nutrition & food research, 52(1), 26-42 (2008-01-19)
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic
Ye-fen Cai et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 694-696 (2012-12-12)
To establish A RP-HPLC method for determination of oleanolic acid and ursolic acid in Damnacanthus indicus from different places. After ultrasonic extraction with 95% ethanol,the separation was achieved on a Kromasil C18 column at 25 degrees C using methanol-2.0% phosphoric
Sophie Dufay et al.
The Journal of pharmacy and pharmacology, 66(10), 1478-1490 (2014-05-16)
Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to
Kunmei Liu et al.
Anti-cancer drugs, 24(5), 494-503 (2013-03-21)
Lung cancer is one of the most death-related cancers worldwide. Ursolic acid (UA), a pentacyclic triterpene acid, has a wide range of anticancer functions such as proapoptosis, antiangiogenesis, and antimetastasis. This study was carried out to explore the inhibition mechanism
Wen-Ling Shih et al.
Molecular carcinogenesis, 52(10), 800-812 (2012-05-03)
Our previous studies demonstrated that autocrine motility factor/phosphoglucose isomerase (AMF/PGI) possesses tumorigenic activities through the modulation of intracellular signaling. We then investigated the effects of ursolic acid (UA), oleanolic acid (OA), tangeretin, and nobiletin against AMF/PGI-mediated oncogenesis in cultured stable
Ming-Chuan Liu et al.
European journal of medicinal chemistry, 58, 128-135 (2012-11-06)
This study designed and synthesized a series of novel ursolic acid derivatives in an attempt to develop potent antitumor agents. Their structures were confirmed using MS, IR, (1)H NMR and (13)C NMR. The inhibitory activities of the title compounds against
L M Bershteĭn
Voprosy onkologii, 58(6), 744-747 (2012-01-01)
In this mini-review the basic evidence about anticancer properties of ursolic acid (UA), the compound belonging to the class of triterpenoids, is given. Beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, UA (as well
Phi Hung Nguyen et al.
Bioorganic & medicinal chemistry letters, 19(23), 6745-6749 (2009-10-20)
Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis
Sara Hoet et al.
Journal of natural products, 70(8), 1360-1363 (2007-07-20)
Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol
Jing-Wei Shao et al.
European journal of medicinal chemistry, 46(7), 2652-2661 (2011-04-26)
Twenty-three ursolic acid (1) derivatives 2-24 (ten novel compounds 8-10, 14-17 and 22-24) modified at the C-3 and the C-28 positions were synthesized, and their structures were confirmed by IR, (1)H NMR, MS, and elemental analysis. The single crystals of
Gülaçti Topçu
Journal of natural products, 69(3), 482-487 (2006-03-28)
Salvia species are important medicinal and culinary plants, and they have been the subject of numerous chemical and biological studies. The bioactive triterpenoids of Salvia species, reported in the literature to date, are reviewed. About 200 triterpenoids, almost 80 of
Changon Seo et al.
Bioorganic & medicinal chemistry letters, 19(10), 2801-2803 (2009-04-14)
Seven phenolic lichen metabolites (1-7) have been isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. A depsidone-type compound, lobaric
Nighat Sultana
Journal of enzyme inhibition and medicinal chemistry, 26(5), 616-642 (2011-03-23)
Medicinal plants are becoming an important research area for novel and bioactive molecules for drug discovery. Novel therapeutic strategies and agents are urgently needed to treat different incurable diseases. Many plant derived active compounds are in human clinical trials. Currently
Hsiu-Chen Huang et al.
Antiviral research, 111, 100-111 (2014-09-28)
Hepatitis B virus (HBV) is a major cause of liver disease and hepatocellular carcinoma. Chronic HBV infection is currently managed with either nucleoside/nucleotide-based or interferon-based therapies, but fails to clear infection in a substantial proportion of cases, and antiviral strategies
Ursolic acid induces neural regeneration after sciatic nerve injury.
Liu B, et al.
Neural Regeneration Research, 8(27), 2510-2510 (2013)
Xiaoan Wen et al.
Journal of medicinal chemistry, 51(12), 3540-3554 (2008-06-04)
Twenty-five naturally occurring pentacyclic triterpenes, 15 of which were synthesized in this study, were biologically evaluated as inhibitors of rabbit muscle glycogen phosphorylase a (GPa). From SAR studies, the presence of a sugar moiety in triterpene saponins resulted in a
Cédric Genet et al.
Journal of medicinal chemistry, 53(1), 178-190 (2009-11-17)
We describe here the biological screening of a collection of natural occurring triterpenoids against the G protein-coupled receptor TGR5, known to be activated by bile acids and which mediates some important cell functions. This work revealed that betulinic (1), oleanolic
Yi-Nan Zhang et al.
Bioorganic & medicinal chemistry, 16(18), 8697-8705 (2008-08-19)
Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified
I-Hsiao Chen et al.
Journal of natural products, 72(7), 1231-1236 (2009-06-19)
Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were
Chang Joo Oh et al.
Free radical research, 41(6), 638-644 (2007-05-23)
A high concentration of glucose has been implicated as a causal factor in initiation and progression of diabetic complications and there is evidence to suggest that hyperglycemia increases the production of free radicals and oxidative stress. Therefore, compounds that scavenge
Liang-Peng Sun et al.
European journal of medicinal chemistry, 46(9), 3630-3638 (2011-06-18)
A series of novel nonphosphonate-based pTyr mimetics comprised (±)-3-(2-(2-fluorobenzyloxy)naphthalen-6-yl)-2-aminopropanoic acid derivatives were identified as reversible and competitive PTP1B inhibitors via a structure-based design approach. Among the compounds studied, 12h was found to have the best in vitro inhibition activity against
Wenlong Wang et al.
Anticancer research, 33(10), 4279-4284 (2013-10-15)
We have previously reported Signal Transducer and Activator of Transcription 3 (STAT3) to be constitutively activated in aldehyde dehydrogenase (ALDH)(+)/cluster of differentiation-133 (CD133)(+) colon cancer-initiating cells. In the present study we tested the efficacy of inhibiting STAT3 signaling in human
Sungbum Kim et al.
Bioorganic & medicinal chemistry letters, 19(2), 508-512 (2008-11-28)
A new hybrid derived from retinol was designed to improve the stability and anti-oxidant activity of retinol and also to add whitening properties besides its usual anti-aging properties. A variety of polyhydroxybenzoates of retinol were prepared either by base-catalysis or
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