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Showing 1-30 of 886 results for "V900084" within Papers
Jian Li et al.
Analytical and bioanalytical chemistry, 407(20), 6137-6148 (2015-06-07)
Benzophenone-type UV filters (BPs) are ubiquitous in the environment. Transformation products (TPs) of BPs with suspected toxicity are likely to be produced during disinfection of water by chlorination. To quickly predict the toxicity of TPs, in this study, a novel
Eva Cífková et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 14-21 (2015-07-25)
The characterization of differences among polar lipid classes in tumors and surrounding normal tissues of 20 kidney cancer patients is performed by hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS). The detailed analysis of identified lipid
Chang-Yin Li et al.
Journal of ethnopharmacology, 162, 225-230 (2015-01-13)
Hydroxysafflor yellow A (HSYA), the major active marker compound isolated from Carthamus tinctorius L., has been demonstrated to possess various attractive pharmacological activities. However, there is a lack of information about the complete clinical pharmacokinetic profiles of HSYA following the
Johana Musso et al.
Analytical and bioanalytical chemistry, 407(5), 1285-1294 (2014-12-20)
Detection of protein biomarkers is of major interest in proteomics. This work reports the analysis of protein biomarkers directly from a biological fluid, human saliva, by surface plasmon resonance imaging coupled to mass spectrometry (SPRi-MS), using a functionalized biochip in
Eszter Németh et al.
Protein science : a publication of the Protein Society, 23(8), 1113-1122 (2014-06-05)
The nuclease domain of colicin E7 (NColE7) promotes the nonspecific cleavage of nucleic acids at its C-terminal HNH motif. Interestingly, the deletion of four N-terminal residues (446-449 NColE7 = KRNK) resulted in complete loss of the enzyme activity. R447A mutation was reported
Hyuck-Soo Kim et al.
Chemosphere, 142, 153-159 (2015-07-04)
Reclaimed tidal land soil (RTLS) often contains high levels of soluble salts and exchangeable Na that can adversely affect plant growth. The current study examined the effect of biochar on the physicochemical properties of RTLS and subsequently the influence on
Ruijuan Xu et al.
PloS one, 9(12), e114049-e114049 (2014-12-03)
Glycyrrhizin (GL) is a widely used food additive which can cause severe pseudoaldosteronism at high doses or after a long period of consumption. The aim of the present study was to develop a physiologically based pharmacokinetic (PBPK) pharmacodynamic (PD) model
Weidang Wu et al.
Cancer science, 106(6), 747-756 (2015-04-14)
L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral amino
Chung-Wei Yang et al.
PloS one, 9(7), e100576-e100576 (2014-07-23)
Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim
Capillary electrophoresis-mass spectrometry as a new approach to analyze neonicotinoid insecticides.
Laura Sánchez-Hernández et al.
Journal of chromatography. A, 1359, 317-324 (2014-08-03)
This paper represents the first report of a capillary electrophoresis (CE) method compatible with mass spectrometry (MS) detection for simultaneously analyzing seven neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid and thiamethoxam). Different variables affecting CE separation (buffer concentration, pH
Sachie Shibayama et al.
Journal of chromatography. A, 1406, 210-214 (2015-07-05)
We have developed a highly sensitive method for the analysis of deoxynucleotide monophosphates (dNMPs), which involves the use of liquid chromatography/mass spectrometry (LC/MS) and a new metal-free column. The new column solves the problem that the phosphate group in dNMPs
Francesco De Pascali et al.
Biochemistry, 53(22), 3679-3688 (2014-04-25)
Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the endothelial NO synthase (eNOS) cofactor tetrahydrobiopterin can trigger eNOS
Ana Freitas et al.
Journal of the science of food and agriculture, 95(1), 44-52 (2014-05-24)
The industrial processing of pineapple generates a high quantity of by-products. To reduce the environmental impact of these by-products and the inherent cost of their treatment, it is important to characterise and valorise these products, converting them into high added
Franziska Heydebreck et al.
Environmental science & technology, 49(14), 8386-8395 (2015-06-25)
The production and use of long-chain perfluoroalkyl substances (PFASs) must comply with national and international regulations. Driven by increasingly stringent regulations, their production has been outsourced to less regulated countries in Asia. In addition, the fluoropolymer industry started to use
Marie Meyer-Monath et al.
Talanta, 138, 231-239 (2015-04-13)
Meconium is the first fecal excretion of newborns. This complex accumulative matrix allows assessing the exposure of the fetus to xenobiotics during the last 6 months of pregnancy. To determine the eventual effect of fetal exposure to micropollutants in this
Robert Krause et al.
The Journal of infectious diseases, 211(3), 445-451 (2014-08-26)
The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine, and T cells has been studied in murine and ex vivo human studies, but data are lacking from patients with invasive fungal infections. Interleukin 17A (IL-17A) is considered an
Ying Liu et al.
Biochimica et biophysica acta, 1848(1 Pt A), 67-75 (2014-10-07)
Molecular interactions between engineered nanomaterials (ENM) and biomembranes are not well understood. This study investigated the effects of particle size and surface functional group on polystyrene nanoparticles' (PNPs) potency for biomembrane disruption. Electrochemical impedance spectroscopy was used to measure changes
Bruce Petrie et al.
The Science of the total environment, 497-498, 553-560 (2014-08-29)
To better understand pharmaceutical fate during wastewater treatment, analysis in both aqueous and particulate phases is needed. Reported herein is a multi-residue method for the determination of ten pharmaceutical drugs and the personal care product triclosan in wastewater matrices. Method
Monika Johansson et al.
Journal of pharmaceutical and biomedical analysis, 100, 215-229 (2014-08-30)
An effective screening procedure to identify and quantify active pharmaceutical substances in suspected illegal medicinal products is described. The analytical platform, consisting of accurate mass determination with liquid chromatography time-of-flight mass spectrometry (LC-QTOF-MS) in combination with nuclear magnetic resonance (NMR)
Fadi Aldeek et al.
Journal of agricultural and food chemistry, 63(26), 5993-6000 (2015-06-16)
In this study, we developed and validated a method for the extraction, identification, and quantitation of penicillin G and its metabolites (penilloic acid and penillic acid) in a variety of citrus fruits by employing sequential liquid/liquid and solid-phase extraction techniques
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 171-178 (2013-12-25)
Paracetamol (acetaminophen, APAP) is a commonly used analgesic drug. Known paracetamol metabolites include the glucuronide, sulfate and mercapturate. N-Acetyl-benzoquinonimine (NAPQI) is considered the toxic intermediate metabolite of paracetamol. In vitro and in vivo studies indicate that paracetamol is also metabolized
Monika Filist et al.
Journal of pharmaceutical and biomedical analysis, 100, 184-189 (2014-08-30)
A sensitive liquid chromatographic-tandem mass spectrometric method was developed and validated to study the pharmacokinetics of a low dose of azithromycin in human plasma. The sample preparation was based on liquid-liquid extraction with the low volume of methyl t-butyl ether.
Mutay Aslan et al.
Clinical and experimental medicine, 15(3), 397-403 (2014-06-14)
The aim of this study was to determine circulating omega-6, omega-3 polyunsaturated fatty acids and prostaglandin E2 (PGE2) levels in steady state sickle cell disease (SCD) patients. Blood was collected from healthy hemoglobin volunteers and steady state homozygous HbSS patients
Sena Caglar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 25-32 (2015-03-10)
On-line solid-phase extraction (SPE) is becoming an increasingly widespread technique in the clean-up of complex matrices such as body fluids, prior to chromatographic analysis. The use of small SPE columns instead of disposable SPE cartridges allows multiple injections and complete
Hsien-Tsung Yao et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 120-127 (2014-05-13)
The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for
Alain Beck et al.
Journal of mass spectrometry : JMS, 50(2), 285-297 (2015-03-25)
The approval process for antibody biosimilars relies primarily on comprehensive analytical data to establish comparability and high similarity with the originator. Mass spectrometry (MS) in combination with liquid chromatography (LC) and electrophoretic methods are the corner stone for comparability and
Wim F P M Van den Hof et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 489-501 (2015-01-07)
In order to improve attrition rates of candidate-drugs there is a need for a better understanding of the mechanisms underlying drug-induced hepatotoxicity. We aim to further unravel the toxicological response of hepatocytes to a prototypical cholestatic compound by integrating transcriptomic
Wenhui Li et al.
Environmental science and pollution research international, 22(22), 17987-17997 (2015-07-15)
As an emerging group of endocrine-disrupting chemicals, parabens have attracted growing attention due to their potential effects on human health. In the present study, the occurrence and distribution of eight parabens, four chlorinated parabens, and their common hydrolysis product, p-hydroxybenzoic
M B Camarada et al.
Physical chemistry chemical physics : PCCP, 17(29), 19001-19011 (2015-07-02)
Cationic dendrimers, such as PAMAM, are known to be positively charged at neutral pH allowing their unspecific interaction with proteins and other cellular components. Especially, ferritin, which has an important role in iron homeostasis, presents a negative electrostatic potential at
Pie Huda et al.
PloS one, 10(7), e0129310-e0129310 (2015-07-02)
64Cu radiolabelled nanodiscs based on the 11 α-helix MSP1E3D1 protein and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine lipids were, for the first time, followed in vivo by positron emission tomography for evaluating the biodistribution of nanodiscs. A cancer tumor bearing mouse model was used for
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