W224847

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In vitro antifungal activity of terpinen-4-ol, eugenol, carvone, 1,8-cineole (eucalyptol) and thymol against mycotoxigenic plant pathogens.

C Morcia et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(3), 415-422 (2012-01-20)

The aim of this study was to examine the effect of five naturally occurring compounds from essential oils on 10 different species of mycotoxigenic fungi involved in several plant diseases. The antifungal activities of terpinen-4-ol, eugenol, carvone, 1,8-cineole (eucalyptol) and

Simultaneous determination of eight active components in Houttuynia cordata injection and its quality control in productive process.

Wei Ji et al.

Journal of separation science, 34(21), 3053-3060 (2011-10-06)

A simple, reliable and effective gas chromatography coupled with flame ionization detection method was developed for the simultaneous determination of eight components (α-pinene, β-pinene, myrcene, limonene, terpinen-4-ol, α-terpineol, bornyl acetate and methyl-n-nonylketone) in Chinese medicine Houttuynia cordata and its injection.

Host plant volatiles serve to increase the response of male European grape berry moths, Eupoecilia ambiguella, to their sex pheromone.

Daniela Schmidt-Büsser et al.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 195(9), 853-864 (2009-08-08)

The European grape berry moth is an important pest in vineyards. Males respond to the female-produced sex pheromone released from a piezo nebulizer in a dose-dependent manner in a wind tunnel: <50% arrive at the source at 5-50 pg/min (underdosed)

Effects of Melaleuca alternifolia (tea tree) essential oil and the major monoterpene component terpinen-4-ol on the development of single- and multistep antibiotic resistance and antimicrobial susceptibility.

Katherine A Hammer et al.

Antimicrobial agents and chemotherapy, 56(2), 909-915 (2011-11-16)

This study examined the effect of subinhibitory Melaleuca alternifolia (tea tree) essential oil on the development of antibiotic resistance in Staphylococcus aureus and Escherichia coli. Frequencies of single-step antibiotic-resistant mutants were determined by inoculating bacteria cultured with or without subinhibitory

Plant essential oils and mastitis disease: their potential inhibitory effects on pro-inflammatory cytokine production in response to bacteria related inflammation.

Ibrahim Taga et al.

Natural product communications, 7(5), 675-682 (2012-07-18)

This paper highlights the role of plant volatile organic compounds, found in essential oils, for the treatment of bacteria related inflammation. This report is focused on tea tree oil, particularly its main compound terpinen-4-ol. Analysis of the published literature shows

Organoleptic Characteristics of Flavor Materials

Mosciano, G.

Perfumer & Flavorist, 30, 59-59 (2005)

Antimicrobial activity of some promising plant oils, molecules and formulations.

Dwijendra Singh et al.

Indian journal of experimental biology, 50(10), 714-717 (2012-12-12)

Plant oils and oil components were screened in vitro for antibacterial and antifungal activity by disc diffusion method. Minimum Inhibitory Concentrations (MICs) of oils (% v/v) against bacteria and fungi were determined by agar dilution method. Results showed that potential

Determination of cytochrome P450 enzymes involved in the metabolism of (-)-terpinen-4-ol by human liver microsomes.

M Miyazawa et al.

Xenobiotica; the fate of foreign compounds in biological systems, 41(12), 1056-1062 (2011-11-08)

The in vitro metabolism of (-)-terpinen-4-ol was examined in human liver microsomes and recombinant enzymes. The biotransformation of (-)-terpinen-4-ol was investigated by gas chromatography-mass spectrometry. (-)-Terpinen-4-ol was found to be oxidized to (-)-(1S,2R,4R)-1,2-epoxy-p-menthan-4-ol, major metabolic product by human liver microsomal

Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol.

S J Greay et al.

Cancer chemotherapy and pharmacology, 65(5), 877-888 (2009-08-15)

To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil (TTO), and its major active terpene component, terpinen-4-ol, against two aggressive murine tumour cell lines, AE17 mesothelioma and B16 melanoma. Effects of TTO and terpinen-4-ol on the

Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.

Kotchaphan Chooluck et al.

Planta medica, 78(16), 1761-1766 (2012-10-03)

The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal

Salt effects on Origanum majorana fatty acid and essential oil composition.

Olfa Baâtour et al.

Journal of the science of food and agriculture, 91(14), 2613-2620 (2011-07-30)

The effects of salt on the essential oil yield and fatty acid composition of aerial parts of two marjoram varieties were investigated. Plants with 6 leaves were treated with NaCl (75mM). Salt treatment led to a reduction in aerial part

Investigation of terpinen-4-ol effects on vascular smooth muscle relaxation.

Rebeca Peres Moreno Maia-Joca et al.

Life sciences, 115(1-2), 52-58 (2014-09-16)

This study investigated the mechanisms underlying the vascular effects of terpinen-4-ol in isolated rat aortic ring preparations. The thoracic aortae of healthy rats were submitted to isometric tension recording. Membrane resting potential and input membrane resistance were measured by conventional

Commentary to the article "Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro".

Krzysztof Cal

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 68(3), 838-839 (2008-02-19)

This note summarises recent studies on skin penetration of terpinen-4-ol, which is the main component of tea tree oil [S.E. Cross, M. Russell, I. Southwell, M.S. Roberts, Human skin penetration of the major components of Australian tea tree oil applied

Culture conditions and salt effects on essential oil composition of sweet marjoram (Origanum majorana) from Tunisia.

Olfa Baâtour et al.

Acta pharmaceutica (Zagreb, Croatia), 62(2), 251-261 (2012-07-04)

O. majorana shoots were investigated for their essential oil (EO) composition. Two experiments were carried out; the first on hydroponic medium in a culture chamber and the second on inert sand in a greenhouse for 20 days. Plants were cultivated

Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells.

R Loughlin et al.

Letters in applied microbiology, 46(4), 428-433 (2008-02-27)

The aim of this study was to compare both the antimicrobial activity of terpinen-4-ol and tea tree oil (TTO) against clinical skin isolates of meticillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (CoNS) and their toxicity against human fibroblast cells. Antimicrobial

Acid-catalyzed condensed-phase reactions of limonene and terpineol and their impacts on gas-to-particle partitioning in the formation of organic aerosols.

Yong Jie Li et al.

Environmental science & technology, 44(14), 5483-5489 (2010-06-17)

We investigated the condensed-phase reactions of biogenic VOCs with C double bond C bonds (limonene, C(10)H(16), and terpineol, C(10)H(18)O) catalyzed by sulfuric acid by both bulk solution (BS) experiments and gas-particle (GP) experiments using a flow cell reactor. Product analysis

The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations.

Antonella Casiraghi et al.

Pharmaceutical development and technology, 15(5), 545-552 (2009-10-22)

This work aimed to evaluate the effect induced by excipients conventionally used for topical dosage forms, namely isopropyl myristate (IPM) or oleic acid (OA) or polyethylene glycol 400 (PEG400) or Transcutol (TR), on the human skin permeability of terpinen-4-ol (T4OL)

Characterization, antibiofilm, and mechanism of action of novel PEG-stabilized lipid nanoparticles loaded with terpinen-4-ol.

Li-ming Sun et al.

Journal of agricultural and food chemistry, 60(24), 6150-6156 (2012-05-30)

Terpinen-4-ol, an active component of tea tree oil, exhibits broad-spectrum antimicrobial activity. However, the high volatilization of terpinen-4-ol and its nonwettability property have limited its application. Our objective was to synthesize novel nanocarriers to deliver and protect terpinen-4-ol. The polyethylene

Phytochemical study of essential oil from the aerial parts of Coleus aromaticus Benth.

G Tewari et al.

Natural product research, 26(2), 182-185 (2011-11-09)

The essential oil composition of Coleus aromaticus Benth. (family Lamiaceae) was examined by capillary GC and GC-MS. Analyses revealed the presence of 28 constituents, of which 16 were identified. Thymol (83.39%) was found to be the major compound, while 1-octen-3-ol

Induction of intrinsic and extrinsic apoptosis pathways in the human leukemic MOLT-4 cell line by terpinen-4-ol.

Patompong Khaw-on et al.

Asian Pacific journal of cancer prevention : APJCP, 13(7), 3073-3076 (2012-09-22)

Terpinen-4-ol is a terpene found in the rhizome of Plai (Zingiber montanum (Koenig) Link ex Dietr.). In this study apoptogenic activity and mechanisms of cell death induced by terpinen-4-ol were investigated in the human leukemic MOLT-4 cell line. Terpinen-4-ol exhibited

Influence of various concentrations of terpene-4-ol enhancer and carbopol-934 mucoadhesive upon the in vitro ocular transport and the in vivo intraocular pressure lowering effects of dorzolamide ophthalmic formulations using albino rabbits.

Mohsen I Afouna et al.

Journal of pharmaceutical sciences, 99(1), 119-127 (2009-06-17)

The objectives of the current study are (i) to maximize the ocular bioavailability of dorzolamide hydrochloride (DZD) through; (a) enhancement of the DZD corneal transport using various concentrations of selected natural terpene-4-ol enhancers, (b) increasing the contact time of the

Volatile compounds in the stem bark of Sclerocarya birrea (Anacardiaceae) possess antimicrobial activity against drug-resistant strains of Helicobacter pylori.

C Njume et al.

International journal of antimicrobial agents, 38(4), 319-324 (2011-07-15)

The aim of this study was to isolate and identify phytochemicals with anti-Helicobacter pylori activity from the stem bark of Sclerocarya birrea. The plant crude extract was fractionated by silica gel column and thin layer chromatography techniques, initially with ethyl

Evaluation of the anticonvulsant activity of terpinen-4-ol.

Damião P de Sousa et al.

Zeitschrift fur Naturforschung. C, Journal of biosciences, 64(1-2), 1-5 (2009-03-28)

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol.

Effect of habituation to tea tree (Melaleuca alternifolia) oil on the subsequent susceptibility of Staphylococcus spp. to antimicrobials, triclosan, tea tree oil, terpinen-4-ol and carvacrol.

Natalie A Thomsen et al.

International journal of antimicrobial agents, 41(4), 343-351 (2013-03-14)

The aim of this study was to seek additional data on the antimicrobial susceptibility of Staphylococcus spp. after habituation to low levels of the topical antimicrobial agent tea tree (Melaleuca alternifolia) oil. Meticillin-susceptible Staphylococcus aureus (MSSA), meticillin-resistant S. aureus (MRSA)

Inhibitory effect of the essential oil from Chamaecyparis obtusa on the growth of food-borne pathogens.

Mi-Jin Park et al.

Journal of microbiology (Seoul, Korea), 48(4), 496-501 (2010-08-28)

In this study, the antibacterial activity of essential oil from Chamaecyparis obtusa (Sieb. et Zucc) leaves and twigs was investigated. The test strains were Klebsiella pneumoniae, Listeria monocytogenes, Salmonella typhimurium, Staphylococcus aureus, Escherichia coli, Legionella pneumophila, and Methicilline-resistant Staphylococcus aureus.

Metabolism of (+)-terpinen-4-ol by cytochrome P450 enzymes in human liver microsomes.

Risa Haigou et al.

Journal of oleo science, 61(1), 35-43 (2011-12-23)

We examined the in vitro metabolism of (+)-terpinen-4-ol by human liver microsomes and recombinant enzymes. The biotransformation of (+)-terpinen-4-ol was investigated by gas chromatography-mass spectrometry (GC-MS). (+)-Terpinen-4-ol was found to be oxidized to (+)-(1R,2S,4S)-1,2-epoxy-p-menthan-4-ol, (+)-(1S,2R,4S)-1,2-epoxy-p-menthan-4-ol, and (4S)-p-menth-1-en-4,8-diol by human liver

The essential oil of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol protect mice from experimental oral candidiasis.

Kentaro Ninomiya et al.

Biological & pharmaceutical bulletin, 35(6), 861-865 (2012-06-13)

The therapeutic efficacy of tea tree oil (TTO), Melaleuca alternifolia, and its main component, terpinen-4-ol, were evaluated in a murine oral candidiasis model. Prednisolone -pretreated mice were orally infected with a fluconazole-susceptible (TIMM 2640) or a resistant (TIMM 3163) strain

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Peter J McNamara et al.

Antimicrobial agents and chemotherapy, 53(5), 1898-1906 (2009-02-19)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-1 production. We report here on

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