Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage.

Effects of zinc pyrithione (ZnPT) and inorganic Zn (ZnCl2) were evaluated on a marine polychaete at sublethal concentrations for 14 days. ZnPT decreased the burrowing activity and AChE activity with higher acute toxicities, implying its cholinergic effect. Both ZnPT and ZnCl2 increased MDA levels at higher concentrations, suggesting lipid peroxidation and oxidative stress. In the ZnPT-treated polychaete, enzymatic activities of CAT and SOD were elevated with an increase in DNA damage, whereas the levels of GSH, GPx, GR, and GST were decreased. However, in the ZnCl2-treated polychaete, the level of GSH and enzymatic activities of CAT, SOD, GPx, GR, and GST were significantly elevated to resist cellular damage. During 97 days depuration experiment, significant mortality and growth retardation were observed in the ZnPT-exposed polychaete. Overall, ZnPT was found to be more toxic than ZnCl2 with the harmful impact on antioxidant defense system and DNA stability in marine polychaete.