- Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.
Bioorganic & medicinal chemistry letters (2005-12-29)
Kathleen H Mortell, David J Anderson, James J Lynch, Sherry L Nelson, Kathy Sarris, Heath McDonald, Reza Sabet, Scott Baker, Prisca Honore, Chih-Hung Lee, Michael F Jarvis, Murali Gopalakrishnan
PMID16380257
ABSTRACT
A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
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L-Phenylalanine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
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L-Phenylalanine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland