- Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.
Bioorganic & medicinal chemistry letters (2007-10-13)
Zhong Zhao, Gian Luca Araldi, Yufang Xiao, Adulla P Reddy, Yihua Liao, Srinivasa Karra, Nadia Brugger, David Fischer, Elizabeth Palmer
PMID17931866
ABSTRACT
Replacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE(2). Compound 10f showed the highest potency and selectivity for EP(4) the receptor.