- Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.
Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.
Journal of natural products (2007-05-11)
Long Cui, Derek Tantoh Ndinteh, MinKyun Na, Phuong Thien Thuong, John Silike-Muruumu, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Jong Seog Ahn, Won Keun Oh
PMID17489632
ABSTRACT
Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 +/- 1.7 to 26.7 +/- 1.2 microM.