- Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
Bioorganic & medicinal chemistry letters (2008-03-04)
Caroline M Reid, Charles Ebikeme, Michael P Barrett, Eva-Maria Patzewitz, Sylke Müller, David J Robins, Andrew Sutherland
PMID18313921
ABSTRACT
A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen.
MATERIALS