- Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages.
Bioorganic & medicinal chemistry (2008-01-22)
Soumyaditya Mula, Debashish Banerjee, Birija S Patro, Sayanti Bhattacharya, Atanu Barik, Sandip K Bandyopadhyay, Subrata Chattopadhyay
PMID18207412
ABSTRACT
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher reactivity with (1)O(2), as revealed from the rate constant values of (1)O(2) quenching by the respective phenolics. APC also prevented the detrimental effects of the Type II photosensitization-induced toxicity to mouse fibroblast L929 cells. The results suggest that APC may play an important role in protecting biological systems against damage, by eliminating (1)O(2) generated from certain endogenous photosensitizers.
MATERIALS
Product Number
Brand
Product Description
Supelco
Mettler-Toledo Calibration substance ME 51143093, Vanillin, traceable to primary standards (LGC)
Sigma-Aldrich
L-Ascorbic acid, puriss. p.a., ACS reagent, reag. ISO, Ph. Eur., 99.7-100.5% (oxidimetric)