- Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
European journal of medicinal chemistry (2011-04-09)
Wei Bi, Yue Bi, Ping Xue, Yanrong Zhang, Xiang Gao, Zhibo Wang, Meng Li, Michele Baudy-Floc'h, Nathaniel Ngerebara, Xiaoxu Li, K Michael Gibson, Lanrong Bi
PMID21474215
ABSTRACT
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.