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  • Selective oxidative decarboxylation of amino acids to produce industrially relevant nitriles by vanadium chloroperoxidase.

Selective oxidative decarboxylation of amino acids to produce industrially relevant nitriles by vanadium chloroperoxidase.

ChemSusChem (2012-05-05)
Andrada But, Jérôme Le Nôtre, Elinor L Scott, Ron Wever, Johan P M Sanders
PMID22556065
ABSTRACT

Industrial nitriles from biomass: Vanadium-chloroperoxidase is successfully used to transform selectively glutamic acid into 3-cyanopropanoic acid, a key intermediate for the synthesis of bio-succinonitrile and bio-acrylonitrile, by using a catalytic amount of a halide salt. This clean oxidative decarboxylation can be applied to mixtures of amino acids obtained from plant waste streams, leading to easily separable nitriles.

MATERIALS
Product Number
Brand
Product Description
C0278
Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, buffered aqueous suspension, ≥3,000 units/mL
C0887
Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, buffered aqueous suspension, 1,000-2,000 units/mg protein (E1%/280)
25810
Sigma-Aldrich
Chloroperoxidase from Caldariomyces fumago, aqueous suspension, brown, >10,000 U/mL