- Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities.
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities.
Bioorganic & medicinal chemistry letters (2005-01-25)
Axel G Griesbeck, Tamer T El-Idreesy, Lars-Oliver Höinck, Johann Lex, Reto Brun
PMID15664819
ABSTRACT
A remarkable increase in antimalarial in vitro activity was achieved by integration of spiroadamantane motifs in 6-alkylidene 1,2,4-trioxanes 3a-h via diastereoselective photooxygenation of allylic alcohols and subsequent BF(3)-catalyzed peroxyacetalization with adamantanone to give the active compounds 3e-h.
MATERIALS