- Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
Bioorganic & medicinal chemistry letters (2005-10-11)
Katrin Groebke Zbinden, Ulrike Obst-Sander, Kurt Hilpert, Holger Kühne, David W Banner, Hans-Joachim Böhm, Martin Stahl, Jean Ackermann, Leo Alig, Lutz Weber, Hans Peter Wessel, Markus A Riederer, Thomas B Tschopp, Thierry Lavé
PMID16213138
ABSTRACT
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.