- Use of methanesulfonic acid in the reductive ring-opening of O-benzylidene acetals.
Use of methanesulfonic acid in the reductive ring-opening of O-benzylidene acetals.
Carbohydrate research (2006-11-23)
Alexander I Zinin, Nelly N Malysheva, Anna M Shpirt, Vladimir I Torgov, Leonid O Kononov
PMID17118348
ABSTRACT
Methanesulfonic acid was shown to be an efficient and convenient substitute for ethereal HCl in reductive 4,6-O-benzylidene acetal ring-opening reaction with sodium cyanoborohydride in THF. Normal regioselectivity was observed, the 6-O-benzyl ethers with free 4-OH group being the major products of the reaction.