- A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection.
A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection.
Organic & biomolecular chemistry (2010-03-20)
Baocun Zhu, Xiaoling Zhang, Hongying Jia, Yamin Li, Haipeng Liu, Weihong Tan
PMID20237677
ABSTRACT
A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.
