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  • Copper-catalyzed decarboxylative cross-coupling of alkynyl carboxylic acids with aryl halides.

Copper-catalyzed decarboxylative cross-coupling of alkynyl carboxylic acids with aryl halides.

Chemical communications (Cambridge, England) (2010-11-05)
Dongbing Zhao, Chao Gao, Xiaoyu Su, Yunqing He, Jingsong You, Ying Xue
ABSTRACT

The copper-catalyzed decarboxylative reactions of alkynyl carboxylic acids with aryl halides were performed under relatively mild reaction conditions. Benzofurans could be further prepared smoothly by a one-pot domino protocol on the basis of decarboxylative cross-coupling of 2-iodophenol.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Phenylpropiolic acid, 99%
Sigma-Aldrich
2-Iodophenol, 98%