- Iodo-cyclizations: novel strategy for the total syntheses of polyrhacitide A and epi-cryptocaryolone.
Iodo-cyclizations: novel strategy for the total syntheses of polyrhacitide A and epi-cryptocaryolone.
Organic letters (2011-01-11)
Debendra K Mohapatra, Eswar Bhimireddy, P Sivarama Krishnarao, Pragna P Das, J S Yadav
PMID21214256
ABSTRACT
Highly stereoselective total syntheses of polyrhacitide A and epi-cryptocaryolone have been achieved in 11 steps with high overall yield of 24% and 28%, respectively, following a recently developed strategy for the construction of trans-2,6-disubstituted-3,4-dihydropyrans. In this report, the versatility of iodo-cyclization for the total syntheses of polyrhacitide A and epi-cryptocaryolone is demonstrated.
MATERIALS