- Effect of various anticoagulant agents on large-volume leukocytapheresis using new Cellsorba CS-180S Filter.
Effect of various anticoagulant agents on large-volume leukocytapheresis using new Cellsorba CS-180S Filter.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (2011-09-03)
Katsura Hohtatsu, Ken Yamaji, Risa Yamada, Keisuke Oda, Michiaki Kageyama, Makio Kusaoi, Shin Onuma, Toshio Kawamoto, Kaoru Sugimoto, Fumio Sekiya, Takayuki Kon, Michihiro Ogasawara, Kazuo Kempe, Hiroshi Tsuda, Yoshinari Takasaki
PMID21884469
ABSTRACT
We conducted a study to evaluate the effect of various anticoagulant agents on large-volume leukocytapheresis using the new Cellsorba CS-180S Filter filled with a changed solution of sodium pyrosulfite and sodium carbonate. We conducted the study on a total of 12 cases of rheumatoid arthritis. As the anticoagulant agents we used sodium citrate, nafamostat mesilate and low molecular weight heparin. The new Cellsorba CS-180S was safely used with the various blood anticoagulant agents. Also, through adjustment of the sodium citrate percentage to the blood flow volume, it is hypothesized that it is possible to increase the neutrophil removal rate.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Sodium metabisulfite, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E223, dry, 97-100.5%