CN
- Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.
Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.
Die Pharmazie (2012-08-15)
J Rojas, V Kumar
PMID22888514
ABSTRACT
Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
MATERIALS
Product Number
Brand
Product Description
Supelco
Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Supelco
Diphenhydramine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Diphenhydramine hydrochloride, European Pharmacopoeia (EP) Reference Standard