[The cytokine status as a criterion for the efficacy of intranasal aerosol therapy with the use of a cycloferon solution in the patients presenting with allergic rhinosinusitis].

The objective of the present study was to estimate the informative value of the variations in the levels of the principal cytokines for the evaluation of the efficacy of local immunotherapy in the immunocompromised individuals presenting with allergic rhinosinusitis (ARS). The study was focused on the analysis of the outcomes of the treatment with the use of a new highly effective therapeutic modality based on the intranasal administration of a cycloferon aerosol solution (125 mg/ml) used in allergologic practice. The main criterion for the efficacy of this treatment was variations of IL-4, IL-8, TNF-alpha, and interferon-gamma levels. The method for the measurement of concentrations of the principal cytokines may be recommended for the evaluation of the efficacy and prognosis of the treatment of allergic rhinosinusitis.