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Merck
CN

Prevention of sevoflurane delirium and agitation with propofol.

Anesthesia progress (2013-06-15)
Zakaria Messieha
ABSTRACT

Emergence delirium and agitation (EAD) associated with sevoflurane general anesthesia are very commonly observed in young children. Such events pose a risk for injury as well as decreased parental satisfaction, especially in the ambulatory and office-based setting. This article reviews the different approaches described in the literature to reduce EAD. A novel approach using a Bispectral Index System (BIS)-guided anesthesia with propofol washout technique is proposed as a viable and effective approach to prevent EAD.

MATERIALS
Product Number
Brand
Product Description

Propofol, European Pharmacopoeia (EP) Reference Standard
Sevoflurane, European Pharmacopoeia (EP) Reference Standard
Propofol for peak identification, European Pharmacopoeia (EP) Reference Standard
Supelco
Propofol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
2,6-Diisopropylphenol, 97%