- Surface modification of biomaterials for conjugation with human fetal osteoblasts.
Surface modification of biomaterials for conjugation with human fetal osteoblasts.
Chimia (2013-08-24)
Françoise Borcard, Phally Kong, Céline Journot, Davide Staedler, Philip N Sturzenegger, Franziska Krauss Juillerat, Urs T Gonzenbach, Lucienne Juillerat-Jeanneret, Sandrine Gerber-Lemaire
PMID23967691
ABSTRACT
Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.