N-Demethylation of dextromethorphan.

N-Demethylation of dextromethorphan.

Journal of pharmaceutical sciences (1980-12-01)

N P Peet

ABSTRACT

In addition to providing an efficient synthesis of 3-methoxymorphinan hydrochloride, the use of 2,2,2-trichloroethyl chloroformate in the N-demethylation of dextromethorphan led to the isolation of two novel zinc salts of 3-methoxymorphinan.

MATERIALS

Product Number

Brand

Product Description

142077

Sigma-Aldrich

2,2,2-Trichloroethyl chloroformate, 98%

23258

Sigma-Aldrich

2,2,2-Trichloroethyl chloroformate, purum, ≥98.0% (NT)