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  • Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.

Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2013-06-13)
J Gueudry, D Boutolleau, M Gueudin, S Burrel, A Miri, B Bodaghi, M Muraine
ABSTRACT

Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acycloguanosine, ≥99% (HPLC), powder
Supelco
Acyclovir, Pharmaceutical Secondary Standard; Certified Reference Material
Aciclovir, European Pharmacopoeia (EP) Reference Standard