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  • Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites.

Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites.

Chemical communications (Cambridge, England) (2013-08-09)
Sara Bianco, Caterina Musetti, A Paul Krapcho, Manlio Palumbo, Claudia Sissi
PMID23925422
ABSTRACT

Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni(2+) or Cu(2+). The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion.

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