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Merck
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Papase as a treatment option for the overgranulating wound.

Journal of wound care (2014-02-15)
N M Mustafah, T Y Chung
ABSTRACT

Overgranulation (also commonly known as hypergranulation) is a common problem in chronic wound management. We describe a case involving a 57-year-old lady with a chronic diabetic foot ulcer, complicated with overgranulation for the past year. She was administered with various treatments, including hydrocortisone 1% cream and hydrofiber, which proved ineffective and further delayed the healing process of her ulcer. We then decided to use crushed Papase tablets applied to her ulcer after a normal saline dressing and prior to an application of secondary dressing. The patient was instructed clearly on the dressing technique to be performed daily at home and was monitored weekly in a foot care clinic. The overgranulation resolved within 5 weeks and the patient continues recieving care to promote epithelialisation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Papain from Carica papaya, solution, light brown, ≥10 U/mg protein (~25 mg/ml)
Sigma-Aldrich
Papain from papaya latex, buffered aqueous suspension, 2× Crystallized, ≥16 units/mg protein
Sigma-Aldrich
Papain from papaya latex, lyophilized powder, ≥10 units/mg protein
Sigma-Aldrich
Papain from papaya latex, lyophilized powder, aseptically filled
Sigma-Aldrich
Papain from papaya latex, crude powder, 1.5-10 units/mg solid