Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules.

Dalton transactions (Cambridge, England : 2003) (2012-08-15)

Živadin D Bugarčić, Jovana Bogojeski, Biljana Petrović, Stephanie Hochreuther, Rudi van Eldik

ABSTRACT

A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.

MATERIALS

Product Number

Brand

Product Description

520780

Sigma-Aldrich

Platinum black, ≥99.9% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

213292

Sigma-Aldrich

sulfur powder, 99.998% trace metals basis

GF25487387

Platinum, wire reel, 0.2m, diameter 1.0mm, hard, 99.95%

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF06440048

Platinum, foil, 4mm disks, thickness 0.05mm, as rolled, 99.95%

GF46789419

Platinum, wire reel, 20m, diameter 0.05mm, annealed, may be used as one component of a thermocouple, 99.99%

GF00716149

Platinum, wire reel, 2m, diameter 0.3mm, as drawn, may be used as one component of a thermocouple, 99.99%

GF03899931

Platinum, wire reel, 2m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%

GF85549832

Platinum, wire reel, 1m, diameter 0.02mm, as drawn, 99.9%

GF52150801

Platinum, foil, 0.5m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF17703930

Platinum, wire reel, 0.5m, diameter 0.25mm, as drawn, 99.99+%

GF64750305

Platinum, wire reel, 0.2m, diameter 0.01mm, wollaston, 99.9%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF19165552

Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF00187163

Platinum, foil, 0.1m coil, thickness 0.15mm, coil width .9mm, as rolled, 99.99%

GF55534046

Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF15087203

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%