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Composite silica coated gold nanosphere and quantum dots nanoparticles for X-ray CT and fluorescence bimodal imaging.

Composite silica coated gold nanosphere and quantum dots nanoparticles for X-ray CT and fluorescence bimodal imaging.

Dalton transactions (Cambridge, England : 2003) (2015-05-27)

Ji-Tao Song, Xiao-Quan Yang, Xiao-Shuai Zhang, Dong-Mei Yan, Ming-Hao Yao, Meng-Yao Qin, Yuan-Di Zhao

ABSTRACT

In this study, silica coated Au nanospheres (Au@SiO2) were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the composite silica coated gold nanosphere and quantum dots nanoparticle (Au@SiO2-QDs/SiO2-PVP) was obtained. This composite structure contained Au and QDs, and it could be used for contrast-enhanced X-ray CT imaging and fluorescence imaging. Characterization showed that the composite nanoparticle had good dispersity, a high fluorescence intensity and a good effect of X-ray absorption, and it was suitable for using as a bimodal imaging probe.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Methanol, suitable for NMR (reference standard)

Sigma-Aldrich

Trioctylphosphine, 97%

Sigma-Aldrich

Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)

Supelco

Ethanol standards 10% (v/v), 10 % (v/v) in H₂O, analytical standard

Sigma-Aldrich

Selenium, pellets, <5 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Cyclohexane, anhydrous, 99.5%

Sigma-Aldrich

Selenium, pellets, <5 mm particle size, ≥99.999% trace metals basis

Sigma-Aldrich

Selenium, powder, −100 mesh, 99.99% trace metals basis

Sigma-Aldrich

Trioctylphosphine, technical grade, 90%

Sigma-Aldrich

Methanol, anhydrous, 99.8%

Sigma-Aldrich

Ammonia-¹⁴N, 99.99 atom % ¹⁴N

Sigma-Aldrich

Methanol, purification grade, 99.8%

Sigma-Aldrich

Selenium, powder, −100 mesh, ≥99.5% trace metals basis

Sigma-Aldrich

Cadmium(II) acetate, anhydrous, 99.995%

Selenium, foil, 25x25mm, thickness 3mm, 99.95%

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%

Sigma-Aldrich

Ethanol, absolute, sales not in Germany, ≥99.8% (vol.)

Sigma-Aldrich

(3-Aminopropyl)triethoxysilane, packaged for use in deposition systems, ≥98%

Sigma-Aldrich

Methanol solution, suitable for NMR (reference standard), 4% in methanol-d₄ (99.8 atom % D), NMR tube size 3 mm × 8 in.

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Hydroxylamine solution, 50 wt. % in H₂O

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Hexadecylamine, technical grade, 90%

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Hexyl alcohol, FCC, FG

Sigma-Aldrich

Trioctylphosphine oxide, technical grade, 90%

Sigma-Aldrich

Hexyl alcohol, natural, ≥98%, FCC, FG

Sigma-Aldrich

(3-Aminopropyl)triethoxysilane, 99%

Sigma-Aldrich

Trioctylphosphine oxide, ReagentPlus^®, 99%

Sigma-Aldrich

Hydroxylamine solution, 50 wt. % in H₂O, 99.999%

Sigma-Aldrich

(3-Aminopropyl)trimethoxysilane, 97%

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, meets USP testing specifications

Sigma-Aldrich

8-Aminopyrene-1,3,6-trisulfonic acid trisodium salt, ≥96.0% (HPCE), solid