- Dependence of tablet brittleness on tensile strength and porosity.
Dependence of tablet brittleness on tensile strength and porosity.
International journal of pharmaceutics (2015-08-01)
Xingchu Gong, Shao-Yu Chang, Frederick Osei-Yeboah, Shubhajit Paul, Sathyanarayana Reddy Perumalla, Limin Shi, Wei-Jhe Sun, Qun Zhou, Changquan Calvin Sun
PMID26226338
ABSTRACT
An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet brittleness and tensile strength. These equations have the potential to facilitate better characterization of tablet mechanical properties and to guide the design and optimization of pharmaceutical tablet products.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Magnesium stearate, puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)