- Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Proceedings of the National Academy of Sciences of the United States of America (2017-09-07)
Yalikun Suofu, Wei Li, Frédéric G Jean-Alphonse, Jiaoying Jia, Nicolas K Khattar, Jiatong Li, Sergei V Baranov, Daniela Leronni, Amanda C Mihalik, Yanqing He, Erika Cecon, Vanessa L Wehbi, JinHo Kim, Brianna E Heath, Oxana V Baranova, Xiaomin Wang, Matthew J Gable, Eric S Kretz, Giulietta Di Benedetto, Timothy R Lezon, Lisa M Ferrando, Timothy M Larkin, Mara Sullivan, Svitlana Yablonska, Jingjing Wang, M Beth Minnigh, Gérald Guillaumet, Franck Suzenet, R Mark Richardson, Samuel M Poloyac, Donna B Stolz, Ralf Jockers, Paula A Witt-Enderby, Diane L Carlisle, Jean-Pierre Vilardaga, Robert M Friedlander
PMID28874589
ABSTRACT
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT