- Activity of rosuvastatin in tachyzoites of Toxoplasma gondii (RH strain) in HeLa cells.
Activity of rosuvastatin in tachyzoites of Toxoplasma gondii (RH strain) in HeLa cells.
Experimental parasitology (2017-08-05)
Raquel Arruda Sanfelice, Laís Fernanda Machado, Larissa Rodrigues Bosqui, Milena Menegazzo Miranda-Sapla, Fernanda Tomiotto-Pellissier, Gabriela de Alcântara Dalevedo, Dielle Ioris, Guilherme Fonseca Reis, Luciano Aparecido Panagio, Italmar Teodorico Navarro, Juliano Bordignon, Ivete Conchon-Costa, Wander Rogério Pavanelli, Ricardo Sergio Almeida, Idessania Nazareth Costa
PMID28774497
ABSTRACT
Due to the toxicity of conventional medication in toxoplasmosis, some drugs are being studied for treating this infection, such as statins, especially rosuvastatin compound, which is efficient in inhibiting the initial isoprenoid biosynthesis processes in humans and the parasite. The goal of this study was to assess the activity of rosuvastatin in HeLa cells infected with the RH strain of T. gondii. In the experiment, HeLa cells (1 × 10